HolderBook

Q32 BIO INC (QTTB)

Institutional ownership reported to the SEC as of Q2 2026, across 10 quarters.

73
Reporting holders
$288.3M
Reported value
75.1%
Of shares outstanding
0.0%
Calls
1.2%
Puts
+20
Holder change

Institutions report 22,370,037 shares against 29,769,466 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.

Calls and puts are the parts of reported value carried in derivative lines rather than shares, and they point in opposite directions: a manager holding calls is positioned for the security, one holding puts against it - or hedging shares they already own, which is why index funds carry so many. Most sites add the two together and report one figure, which averages away the only interesting part.

Holders

Download these holders as CSV

FilerValueShares Their book Held Change
ORBIMED ADVISORS LLC$52.6M4,127,9870.97%10q+83.2%+$23.9M
Boxer Capital Management, LLC$40.1M3,149,3103.02%newNEW
Atlas Venture Life Science Advisors, LLC$34.6M2,717,1063.93%10q+29.9%+$8.0M
BVF INC/IL$29.9M2,350,0000.77%newNEW
RA CAPITAL MANAGEMENT, L.P.$29.7M2,332,4570.26%newNEW
Point72 Asset Management, L.P.$14.9M1,173,3960.02%newNEW
Opaleye Management Inc.$11.9M931,0001.07%3q-25.9%-$4.1M
Logos Global Management LP$10.2M800,0000.44%newNEW
SummitTX Capital, L.P.$9.3M733,7740.24%newNEW
Ikarian Capital, LLC$8.0M430,0000.86%newNEW
VANGUARD CAPITAL MANAGEMENT LLC$6.6M518,8030.00%2q+69.3%+$2.7M
Woodline Partners LP$3.6M286,2120.01%newNEW
AMERICAN CENTURY COMPANIES INC$3.5M272,7520.00%2q+1353.1%+$3.2M
Sanofi$3.1M244,0830.58%7qHELD
CITADEL ADVISORS LLC$3.1M241,3260.00%5q+1458.9%+$2.9M
ACADIAN ASSET MANAGEMENT LLC$2.8M218,2340.00%6q+26.4%+$581.3K
ACORN CAPITAL ADVISORS, LLC$2.8M216,1710.75%7q-31.4%-$1.3M
BOOTHBAY FUND MANAGEMENT, LLC$2.4M130,4270.03%newNEW
RENAISSANCE TECHNOLOGIES LLC$2.3M179,6000.00%5q-13.2%-$348.0K
JANE STREET GROUP, LLC$2.1M162,7470.00%3q+148.1%+$1.2M
MONIMUS CAPITAL MANAGEMENT, LP$1.7M132,0360.39%2q-1.7%-$29.0K
GEODE CAPITAL MANAGEMENT, LLC$1.6M122,6900.00%10q+3.8%+$57.8K
BlackRock, Inc.$1.5M118,5070.00%8q+37.6%+$412.3K
STATE STREET CORP$1.3M104,4280.00%9q+151.5%+$801.5K
MARSHALL WACE, LLP$854.2K67,0450.00%2q+27.9%+$186.1K
VANGUARD FIDUCIARY TRUST CO$843.6K66,2170.00%2q+32.4%+$206.7K
Carlyle Group Inc.$769.0K60,3630.01%10q-94.5%-$13.3M
TWO SIGMA INVESTMENTS, LP$631.7K49,5820.00%4q+17.1%+$92.2K
Quadrature Capital Ltd$463.7K36,3960.00%newNEW
Cambridge Investment Research Advisors, Inc.$460.0K36,1620.00%2q+3.2%+$14.5K
BRIDGEWAY CAPITAL MANAGEMENT, LLC$441.0K34,6130.01%2q+174.4%+$280.3K
DAFNA Capital Management LLC$419.1K32,8960.08%newNEW
Knott David M Jr$387.4K30,4120.20%newNEW
Affinity Asset Advisors, LLC$353.9K27,7770.02%10qHELD
Squarepoint Ops LLC$303.1K23,7900.00%newNEW
NORTHERN TRUST CORP$301.1K23,6310.00%8q-5.6%-$17.9K
DIMENSIONAL FUND ADVISORS LP$300.5K23,5880.00%newNEW
SUSQUEHANNA INTERNATIONAL GROUP, LLP$297.4K23,3420.00%newNEW
MANGROVE PARTNERS IM, LLC$282.2K22,1500.02%newNEW
LPL Financial LLC$231.5K18,1700.00%newNEW
HRT FINANCIAL LP$203.0K15,9490.00%newNEW
UBS Group AG$191.2K15,0080.00%10q+5458.5%+$187.8K
Balyasny Asset Management L.P.$157.2K12,3420.00%newNEW
ExodusPoint Capital Management, LP$144.4K11,3360.00%newNEW
MILLENNIUM MANAGEMENT LLC$139.2K10,9280.00%newNEW
XTX Topco Ltd$138.5K10,8740.00%newNEW
MORGAN STANLEY$82.3K6,4560.00%10q-32.5%-$39.5K
Vanguard Global Advisers, LLC$61.5K4,8240.00%2q+151.9%+$37.1K
FMR LLC$43.2K3,3880.00%10qHELD
CITIGROUP INC$36.8K2,8880.00%newNEW
Private Wealth Asset Management, LLC$21.7K1,7000.00%newNEW
Arax Advisory Partners$14.2K1,1110.00%5q-3.2%
FEDERATED HERMES, INC.$13.4K1,0500.00%8q-53.8%-$15.6K
Rockefeller Capital Management L.P.$7.4K5770.00%4qHELD
JONES FINANCIAL COMPANIES LLLP$6.6K5000.00%3qHELD
Russell Investments Group, Ltd.$5.8K4540.00%8qHELD
BNP PARIBAS FINANCIAL MARKETS$3.9K3030.00%9qHELD
EverSource Wealth Advisors, LLC$3.1K2400.00%7q-94.8%-$56.1K
SIMPLEX TRADING, LLC$2.5Koptions only0.00%newOPTIONS
NISA INVESTMENT ADVISORS, LLC$2.1K1660.00%5qHELD
Truvestments Capital LLC$2.1K1620.00%newNEW
OSAIC HOLDINGS, INC.$1.6K1240.00%10qHELD
Allworth Financial LP$1.4K1080.00%7q+10.2%
SBI Securities Co., Ltd.$1.2K940.00%7q-9.6%
Federation des caisses Desjardins du Quebec$888700.00%10qHELD
Clearstead Advisors, LLC$854670.00%newNEW
Caitong International Asset Management Co., Ltd$573450.00%newNEW
GROUP ONE TRADING LLC$433340.00%4qHELD
HARBOUR INVESTMENTS, INC.$140110.00%9qHELD
MERCER GLOBAL ADVISORS INC /ADV$2520.00%newNEW
AdvisorNet Financial, Inc$2520.00%10qHELD
DANSKE BANK A/S$1310.00%8qHELD
ROYAL BANK OF CANADA$0430.00%10q-98.4%

Five percent filings

Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →

FiledFormFiler % of class
2026-10-0913GFrazier Life Sciences Public Fund, L.P.with 8 co-filers5.9%
2026-08-1413G/ASirenia Capital Management LPwith 1 co-filers0.0%
2026-08-1413G/APoint72 Asset Management, L.P.with 2 co-filers5.0%
2026-07-3113G/AOpaleye Management Inc.with 2 co-filers5.5%
2026-07-2013D/AORBIMED ADVISORS LLCwith 2 co-filers13.9%
2026-07-1013GBoxer Capital Management, LLCwith 3 co-filers13.3%
2026-07-0613G/AThe Carlyle Group Inc.with 9 co-filers4.1%

What the insiders did

Open market purchases and sales reported on Form 4 in the last 180 days. Grants, option exercises and shares surrendered to cover tax are left out: they are compensation rather than a decision to buy or sell. Where a broker filled one order in tranches the lines are summed, because it was one decision.

Ten percent owners and entities

Usually an institution that crossed a reporting threshold, or a company taking a strategic stake, rather than an individual with a view.

DateInsiderRoleSideSharesValue
2026-05-28ORBIMED ADVISORS LLCDirector, 10% ownerBought1,875,000$15.0M ×2
2026-05-28Xu DiyongDirector, 10% ownerBought1,875,000$15.0M ×2

Quarter by quarter

Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.

QuarterHoldersValue SharesNewAdded TrimmedOptions
Q2 202673$288.3M22,370,0372918121.2%
Q1 202653$60.6M9,428,97291480.0%
Q4 202551$26.7M8,043,84679190.0%
Q3 202552$16.6M8,428,60478170.0%
Q2 202562$13.4M8,984,9841011190.1%
Q1 202574$15.5M9,406,713915190.1%
Q4 202493$38.4M10,995,362322191.5%
Q3 202473$406.0M9,112,102261880.0%
Q2 202455$144.2M8,067,948191660.0%
Q1 202439$126.1M7,431,78739000.2%