HolderBook

ALPINE IMMUNE SCIENCES INC (ALPN)

Institutional ownership reported to the SEC as of Q1 2024, across 22 quarters.

161
Reporting holders
$2.5B
Reported value
0.7%
Held as options
+36
Holder change

Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.

Holders

FilerValueShares Their book Held Change
Decheng Capital LLC$329.7M8,317,92444.22%2q+17.4%+$48.9M
Avoro Capital Advisors LLC$228.9M5,775,0002.67%newNEW
BlackRock Inc.$141.7M3,575,0920.00%22q+16.9%+$20.5M
Frazier Life Sciences Management, L.P.$124.1M3,131,0085.24%9qHELD
STATE STREET CORP$112.8M2,845,8390.01%12q+104.7%+$57.7M
VANGUARD GROUP INC$107.5M2,712,2850.00%22q+21.4%+$18.9M
Cormorant Asset Management, LP$107.0M2,700,0004.69%3q+5.9%+$5.9M
ORBIMED ADVISORS LLC$106.3M2,680,4961.96%22q+5.7%+$5.8M
MORGAN STANLEY$93.9M2,368,9350.00%16q+64.8%+$36.9M
Lynx1 Capital Management LP$89.3M2,253,18323.00%10q-40.9%-$61.9M
Paradigm Biocapital Advisors LP$84.1M2,121,1632.96%9q-33.2%-$41.8M
Darwin Global Management, Ltd.$78.6M1,982,01610.46%newNEW
COMMODORE CAPITAL LP$54.5M1,375,0003.64%7q-14.6%-$9.3M
Octagon Capital Advisors LP$49.2M1,241,3005.90%7qHELD
Avidity Partners Management LP$46.6M1,174,7001.50%newNEW
GREAT POINT PARTNERS LLC$44.7M1,128,4996.97%8q-69.5%-$102.1M
FRANKLIN RESOURCES INC$43.3M1,093,2030.01%2q-10.4%-$5.0M
GEODE CAPITAL MANAGEMENT, LLC$36.1M910,5990.00%22q+19.1%+$5.8M
TWO SIGMA ADVISERS, LP$26.5M668,7750.06%15q+153.3%+$16.0M
Vivo Capital, LLC$20.8M520,5051.63%4q-36.5%-$11.9M
TWO SIGMA INVESTMENTS, LP$20.6M519,9710.05%4q+37.4%+$5.6M
Nuveen Asset Management, LLC$20.3M513,1750.01%12q+294.9%+$15.2M
First Light Asset Management, LLC$19.9M501,2431.52%newNEW
JANUS HENDERSON GROUP PLC$17.8M450,8270.01%2q-22.7%-$5.2M
D. E. Shaw & Co., Inc.$17.0M428,5550.01%3q+45.0%+$5.3M
Candriam S.C.A.$16.5M415,0000.11%2q-11.7%-$2.2M
EVENTIDE ASSET MANAGEMENT, LLC$16.2M408,5420.25%newNEW
Artal Group S.A.$16.1M405,7840.41%15q+699.4%+$14.1M
Balyasny Asset Management L.P.$14.8M372,9950.03%newNEW
Ikarian Capital, LLC$14.4M261,3651.58%2q-46.4%-$12.5M
Vestal Point Capital, LP$13.9M350,0001.15%newNEW
NORTHERN TRUST CORP$13.5M341,7010.00%15q+15.2%+$1.8M
CHARLES SCHWAB INVESTMENT MANAGEMENT INC$13.4M339,1420.00%12q+14.0%+$1.7M
Bank of New York Mellon Corp$12.9M325,9430.00%15q+218.5%+$8.9M
ADAGE CAPITAL PARTNERS GP, L.L.C.$12.3M310,0000.02%2q-56.6%-$16.0M
Invesco Ltd.$10.8M272,6270.00%3q+12.8%+$1.2M
VOLORIDGE INVESTMENT MANAGEMENT, LLC$10.6M267,2320.04%2q+14.3%+$1.3M
Nan Fung Group Holdings Ltd$10.5M263,9409.69%3qHELD
JANE STREET GROUP, LLC$10.1M177,4340.00%3q+155.5%+$6.2M
Atika Capital Management LLC$10.1M256,0001.00%newNEW
Woodline Partners LP$10.1M254,3340.09%4q-74.6%-$29.6M
SUSQUEHANNA INTERNATIONAL GROUP, LLP$9.8M109,8600.00%2q+382.4%+$7.8M
GOLDMAN SACHS GROUP INC$9.5M240,4350.00%10q+21.5%+$1.7M
FMR LLC$9.5M238,5610.00%9qHELD
Rafferty Asset Management, LLC$9.3M234,6250.03%2q+192.7%+$6.1M
Integral Health Asset Management, LLC$9.1M230,0000.85%newNEW
CITADEL ADVISORS LLC$8.5M142,8790.00%4q-83.7%-$43.8M
CITIGROUP INC$8.2M207,4960.01%14q+480.0%+$6.8M
Walleye Capital LLC$8.2M206,1040.01%5q-43.7%-$6.4M
DEUTSCHE BANK AG\$8.1M204,4790.00%13q+57.9%+$3.0M
BANK OF AMERICA CORP /DE/$8.0M202,4140.00%13q+120.6%+$4.4M
SILVERARC CAPITAL MANAGEMENT, LLC$7.9M199,0202.19%2q-33.2%-$3.9M
JENNISON ASSOCIATES LLC$7.6M191,9740.01%2q+36.1%+$2.0M
DIMENSIONAL FUND ADVISORS LP$7.6M191,7790.00%22q-18.0%-$1.7M
Qube Research & Technologies Ltd$6.5M163,3230.01%3q-20.6%-$1.7M
WELLINGTON MANAGEMENT GROUP LLP$6.4M161,1450.00%3q+46.7%+$2.0M
UBS Group AG$6.1M153,4730.00%6q+133.2%+$3.5M
Ensign Peak Advisors, Inc$5.6M140,0430.01%2q+7.7%+$399.1K
FEDERATED HERMES, INC.$5.5M138,9810.01%2q+37977.0%+$5.5M
Hillsdale Investment Management Inc.$5.3M133,9600.42%newNEW
Tri Locum Partners LP$4.8M120,6871.66%newNEW
TD Asset Management Inc$4.7M118,4180.00%2q+256.7%+$3.4M
Exome Asset Management LLC$4.6M117,0003.97%2q-32.6%-$2.2M
Trexquant Investment LP$4.6M115,7760.09%4q+115.3%+$2.5M
Point72 Asset Management, L.P.$4.4M110,7000.01%newNEW
ALGERT GLOBAL LLC$4.3M217,6820.17%3q+284.7%+$3.2M
BOOTHBAY FUND MANAGEMENT, LLC$3.9M67,9720.07%2q-41.8%-$2.8M
Rhenman & Partners Asset Management AB$3.4M85,5000.32%newNEW
MANUFACTURERS LIFE INSURANCE COMPANY, THE$3.3M83,8680.00%4q+213.2%+$2.3M
BAKER BROS. ADVISORS LP$3.2M81,5780.04%newNEW
Altium Capital Management LP$3.1M77,8481.22%2q-1.1%-$34.7K
BNP PARIBAS FINANCIAL MARKETS$3.1M77,7840.00%12q-27.3%-$1.2M
Raymond James Financial Services Advisors, Inc.$3.0M76,5080.00%newNEW
EAM Investors, LLC$3.0M74,8990.46%2q-54.0%-$3.5M
Swiss National Bank$2.5M63,5000.00%3q+11.0%+$249.7K
JPMORGAN CHASE & CO$2.3M58,9180.00%12q-10.9%-$286.6K
RHUMBLINE ADVISERS$2.2M54,5430.00%8q+24.8%+$429.0K
Cinctive Capital Management LP$2.1M54,0710.10%newNEW
Monashee Investment Management LLC$2.1M52,5460.25%2q-29.7%-$881.8K
Artia Global Partners LP$2.0M51,7140.41%newNEW
Moody Aldrich Partners LLC$2.0M50,7980.34%newNEW
Tudor Investment Corp Et Al$2.0M50,7290.01%newNEW
BARCLAYS PLC$1.9M49,1700.00%13q-38.8%-$1.2M
ALPS ADVISORS INC$1.8M46,2220.01%2q+16.7%+$262.9K
VICTORY CAPITAL MANAGEMENT INC$1.8M45,0640.00%newNEW
SPHERA FUNDS MANAGEMENT LTD.$1.8M44,8410.25%7q-80.9%-$7.5M
ALLIANCEBERNSTEIN L.P.$1.6M41,2900.00%4q+37.5%+$446.0K
AWM Investment Company, Inc.$1.6M40,0000.21%2qHELD
ClariVest Asset Management LLC$1.5M38,8730.16%2qHELD
CAPSTONE INVESTMENT ADVISORS, LLC$1.5M38,2120.01%2q+51.1%+$512.3K
UBS ASSET MANAGEMENT AMERICAS LLC$1.5M37,9250.00%2q+215.8%+$1.0M
PROFUND ADVISORS LLC$1.4M36,3720.06%2q+170.7%+$909.1K
Jefferies Financial Group Inc.$1.4M35,0000.01%2q-65.1%-$2.6M
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM$1.3M32,8230.00%12q+5.3%+$65.8K
CREDIT SUISSE AG/$1.3M32,2110.00%3q+20.4%+$216.7K
Legal & General Group Plc$1.2M30,9010.00%12q+17.7%+$183.9K
STATE OF WISCONSIN INVESTMENT BOARD$1.2M30,1330.00%3q+4.1%+$46.9K
PRELUDE CAPITAL MANAGEMENT, LLC$1.1M27,1000.06%2q-34.7%-$570.8K
Ziegler Capital Management, LLC$950.6K23,9820.04%2q+7.1%+$63.4K
Capula Management Ltd$950.2K23,9700.02%newNEW

Showing the largest 100 of 179 reported holders.

Quarter by quarter

Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.

QuarterHoldersValue SharesNewAdded TrimmedOptions
Q1 2024161$2.5B62,552,3885362380.7%
Q4 2023125$1.1B57,526,401495870.0%
Q3 202380$490.1M42,823,8031631180.0%
Q2 202369$363.3M35,338,1751831100.0%
Q1 202349$255.0M33,033,690421120.0%
Q4 202249$225.4M30,671,61282670.0%
Q3 202269$284.0M39,450,8391722170.0%
Q2 202257$204.4M24,016,723822170.0%
Q1 202257$221.9M24,732,244716160.0%
Q4 202153$257.3M18,582,57892280.0%
Q3 202144$163.5M15,328,774418130.0%
Q2 202147$118.5M13,168,360158130.0%
Q1 202147$145.0M13,701,7521014100.0%
Q4 202043$165.5M13,155,520121270.0%
Q3 202033$110.3M12,551,37817930.0%
Q2 202019$69.2M7,123,0518420.0%
Q1 202015$23.5M8,151,7671230.0%
Q4 201918$32.5M8,458,8011230.0%
Q3 201918$34.4M8,695,9271450.0%
Q2 201923$36.7M8,711,7702660.0%
Q1 201923$59.9M8,735,2473690.0%
Q4 201823$27.6M7,487,8330110.0%