ZYMEWORKS INC (ZYME)
Institutional ownership reported to the SEC as of Q2 2026, across 31 quarters.
198
Reporting holders
$1.8B
Reported value
98.1%
Of shares outstanding
0.5%
Held as options
-7
Holder change
Institutions report 69,612,317 shares against 70,959,241 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| EcoR1 Capital, LLC | $600.4M | 22,970,388 | 29.19% | 15q | HELD |
| Rubric Capital Management LP | $183.0M | 7,000,000 | 1.68% | 15q | HELD |
| BlackRock, Inc. | $111.1M | 4,251,030 | 0.00% | 8q | -6.7%-$7.9M |
| PERCEPTIVE ADVISORS LLC | $109.3M | 4,182,953 | 1.64% | 15q | +19.2%+$17.6M |
| BVF INC/IL | $95.4M | 3,649,142 | 2.44% | 15q | -2.3%-$2.2M |
| Assenagon Asset Management S.A. | $65.5M | 2,504,054 | 0.04% | 8q | +244.0%+$46.4M |
| MORGAN STANLEY | $58.3M | 2,231,260 | 0.00% | 15q | -10.1%-$6.5M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $46.6M | 1,781,116 | 0.05% | 3q | -6.7%-$3.3M |
| VANGUARD CAPITAL MANAGEMENT LLC | $40.8M | 1,558,998 | 0.00% | 2q | -8.6%-$3.8M |
| Nextech Invest Ltd. | $29.1M | 1,113,946 | 1.38% | 6q | HELD |
| STATE STREET CORP | $28.4M | 1,088,216 | 0.00% | 15q | +7.6%+$2.0M |
| DIMENSIONAL FUND ADVISORS LP | $26.0M | 994,955 | 0.00% | 14q | -12.7%-$3.8M |
| CITADEL ADVISORS LLC | $25.3M | 914,136 | 0.00% | 15q | -20.5%-$6.5M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $23.3M | 889,802 | 0.03% | new | NEW |
| FMR LLC | $18.4M | 702,568 | 0.00% | 13q | +5.3%+$925.7K |
| GEODE CAPITAL MANAGEMENT, LLC | $18.1M | 692,410 | 0.00% | 14q | +4.9%+$848.7K |
| Prosight Management, LP | $17.6M | 674,434 | 3.04% | 10q | +25.1%+$3.5M |
| Qube Research & Technologies Ltd | $15.5M | 593,590 | 0.01% | 5q | +15.9%+$2.1M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $13.3M | 510,032 | 0.00% | 2q | +2.0%+$265.5K |
| Redmile Group, LLC | $12.9M | 491,654 | 0.86% | 15q | HELD |
| Capricorn Fund Managers Ltd | $12.7M | 486,529 | 1.00% | 3q | -51.7%-$13.6M |
| GOLDMAN SACHS GROUP INC | $12.3M | 470,822 | 0.00% | 15q | -21.5%-$3.4M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $10.9M | 418,497 | 0.00% | 4q | -43.7%-$8.5M |
| DEUTSCHE BANK AG\ | $10.4M | 397,190 | 0.00% | 15q | -56.9%-$13.7M |
| Hillsdale Investment Management Inc. | $10.0M | 382,922 | 0.23% | 7q | +10.8%+$975.0K |
| FIRST TRUST ADVISORS LP | $8.9M | 340,363 | 0.01% | new | NEW |
| Granahan Investment Management, LLC | $8.8M | 336,157 | 0.31% | 15q | +34.0%+$2.2M |
| NORTHERN TRUST CORP | $8.4M | 321,073 | 0.00% | 15q | HELD |
| Pictet Asset Management Holding SA | $7.4M | 308,187 | 0.01% | 3q | +3229.6%+$7.2M |
| PICTON MAHONEY ASSET MANAGEMENT | $7.1M | 271,343 | 0.05% | 15q | +5.7%+$383.0K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5.9M | options only | 0.00% | 15q | OPTIONS |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $5.8M | 223,766 | 0.04% | 13q | +36.7%+$1.6M |
| BANK OF AMERICA CORP /DE/ | $5.7M | 219,071 | 0.00% | 15q | -7.5%-$462.2K |
| WELLS FARGO & COMPANY/MN | $5.7M | 217,199 | 0.00% | 15q | -42.7%-$4.2M |
| SummitTX Capital, L.P. | $5.5M | 210,802 | 0.14% | 3q | -34.4%-$2.9M |
| Man Group plc | $5.5M | 210,779 | 0.01% | 6q | +11.0%+$546.0K |
| FEDERATED HERMES, INC. | $4.9M | 187,995 | 0.01% | 11q | +3.1%+$146.0K |
| RAYMOND JAMES FINANCIAL INC | $4.4M | 166,416 | 0.00% | 7q | -5.7%-$261.3K |
| STATE OF WISCONSIN INVESTMENT BOARD | $4.1M | 155,579 | 0.01% | 14q | +135.3%+$2.3M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4.0M | 152,416 | 0.00% | 13q | -17.7%-$855.0K |
| Sixth Street Partners Management Company, L.P. | $4.0M | 152,416 | 0.00% | new | NEW |
| KENNEDY CAPITAL MANAGEMENT LLC | $3.8M | 145,386 | 0.07% | 16q | -1.9%-$74.2K |
| D. E. Shaw & Co., Inc. | $3.8M | 144,807 | 0.00% | 10q | -38.5%-$2.4M |
| DIADEMA PARTNERS LP | $3.7M | 142,132 | 0.47% | 6q | HELD |
| CITIGROUP INC | $3.4M | 131,441 | 0.00% | 15q | +15.0%+$447.4K |
| Bank of New York Mellon Corp | $3.4M | 131,106 | 0.00% | 13q | +5.6%+$183.0K |
| XTX Topco Ltd | $3.3M | 125,877 | 0.04% | 3q | -12.5%-$470.7K |
| Nuveen, LLC | $3.1M | 119,389 | 0.00% | 6q | -81.7%-$13.9M |
| PANAGORA ASSET MANAGEMENT INC | $3.1M | 118,603 | 0.01% | 5q | -42.7%-$2.3M |
| UBS Group AG | $3.0M | 115,095 | 0.00% | 15q | -33.0%-$1.5M |
| Invesco Ltd. | $2.9M | 112,212 | 0.00% | 13q | -10.7%-$350.7K |
| AQR CAPITAL MANAGEMENT LLC | $2.9M | 111,282 | 0.00% | 13q | +22.7%+$538.8K |
| WELLINGTON MANAGEMENT GROUP LLP | $2.9M | 110,014 | 0.00% | 13q | -20.7%-$749.6K |
| Tidal Investments LLC | $2.8M | 105,615 | 0.00% | 2q | +0.7%+$17.9K |
| Tema ETFs LLC | $2.8M | 105,615 | 0.09% | 6q | +0.7%+$17.9K |
| PLATINUM INVESTMENT MANAGEMENT LTD | $2.7M | 105,184 | 0.68% | 15q | HELD |
| Manatuck Hill Partners, LLC | $2.6M | 100,000 | 0.87% | 2q | +150.0%+$1.6M |
| JPMORGAN CHASE & CO | $2.6M | 106,398 | 0.00% | 14q | -6.7%-$184.9K |
| KORNITZER CAPITAL MANAGEMENT INC /KS | $2.3M | 88,800 | 0.05% | 3q | HELD |
| MACKENZIE FINANCIAL CORP | $2.3M | 87,745 | 0.00% | 5q | +6.1%+$131.2K |
| PRINCIPAL FINANCIAL GROUP INC | $2.2M | 84,990 | 0.00% | 2q | +8.2%+$168.4K |
| Y-Intercept (Hong Kong) Ltd | $2.2M | 83,455 | 0.04% | new | NEW |
| LMR Partners LLP | $2.2M | 82,500 | 0.01% | new | NEW |
| AMERIPRISE FINANCIAL INC | $2.2M | 82,264 | 0.00% | 4q | -44.6%-$1.7M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $2.1M | 81,359 | 0.00% | 14q | -74.5%-$6.2M |
| VANGUARD FIDUCIARY TRUST CO | $2.1M | 80,120 | 0.00% | 2q | -5.1%-$112.0K |
| STIFEL FINANCIAL CORP | $2.0M | 77,214 | 0.00% | 15q | +0.6%+$12.0K |
| FRANKLIN RESOURCES INC | $2.0M | 76,528 | 0.00% | 4q | -1.5%-$29.6K |
| RHUMBLINE ADVISERS | $2.0M | 75,066 | 0.00% | 13q | HELD |
| Swiss National Bank | $1.9M | 74,200 | 0.00% | 14q | HELD |
| MARTINGALE ASSET MANAGEMENT L P | $1.9M | 73,282 | 0.05% | 2q | +123.7%+$1.1M |
| TWO SIGMA INVESTMENTS, LP | $1.9M | 71,874 | 0.00% | new | NEW |
| Dana Investment Advisors, Inc. | $1.9M | 71,660 | 0.05% | 3q | +27.7%+$406.6K |
| CREDIT AGRICOLE S A | $1.9M | 71,000 | 0.00% | 3q | -5.3%-$104.6K |
| Fisher Asset Management, LLC | $1.9M | 70,775 | 0.00% | 9q | -30.2%-$801.6K |
| SEGALL BRYANT & HAMILL, LLC | $1.7M | 66,836 | 0.02% | 2q | +46.2%+$551.8K |
| Verdad Advisers, LP | $1.7M | 66,688 | 1.67% | 2q | -19.4%-$418.5K |
| Susquehanna Portfolio Strategies, LLC | $1.7M | 65,248 | 0.03% | 5q | -34.6%-$903.1K |
| Campbell & CO Investment Adviser LLC | $1.6M | 60,874 | 0.08% | 5q | +10.9%+$156.6K |
| SIMPLEX TRADING, LLC | $1.5M | 19,431 | 0.00% | 15q | +1354.4%+$1.4M |
| ROYAL BANK OF CANADA | $1.5M | 56,278 | 0.00% | 15q | +18.8%+$233.1K |
| ALLIANCEBERNSTEIN L.P. | $1.4M | 55,896 | 0.00% | 13q | HELD |
| Virtus Investment Advisers, LLC | $1.3M | 50,825 | 0.31% | 6q | +374.9%+$1.0M |
| ENVESTNET ASSET MANAGEMENT INC | $1.3M | 48,675 | 0.00% | 15q | +20.4%+$215.8K |
| RITHOLTZ WEALTH MANAGEMENT | $1.3M | 48,486 | 0.01% | 11q | +100.0%+$633.7K |
| Russell Investments Group, Ltd. | $1.3M | 47,867 | 0.00% | 15q | +0.9%+$10.9K |
| Quantinno Capital Management LP | $1.2M | 47,642 | 0.00% | 3q | +20.2%+$209.2K |
| Legal & General Group Plc | $1.1M | 43,160 | 0.00% | 14q | +64.7%+$443.0K |
| VICTORY CAPITAL MANAGEMENT INC | $1.1M | 42,524 | 0.00% | 10q | HELD |
| MARSHALL WACE, LLP | $1.1M | 40,948 | 0.00% | 2q | +27.1%+$228.1K |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $1.0M | 39,534 | 0.00% | 13q | +6.5%+$62.9K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $965.1K | 36,922 | 0.00% | 2q | -13.7%-$153.3K |
| TUDOR INVESTMENT CORP ET AL | $953.4K | 36,471 | 0.00% | 5q | -1.1%-$10.6K |
| HighTower Advisors, LLC | $943.7K | 36,100 | 0.00% | 2q | HELD |
| Persistent Asset Partners Ltd | $939.3K | 35,935 | 0.28% | 3q | HELD |
| HighVista Strategies LLC | $889.1K | 34,013 | 0.20% | 2q | HELD |
| COMMONWEALTH EQUITY SERVICES, LLC | $837.8K | 32,052 | 0.00% | 15q | +23.1%+$157.4K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $807.4K | 30,886 | 0.00% | 13q | -2.2%-$18.5K |
| Creative Planning | $777.2K | 29,731 | 0.00% | 7q | -8.2%-$69.6K |
| SBI Okasan Asset Management Co.Ltd. | $771.2K | 32,000 | 0.03% | 3q | HELD |
Showing the largest 100 of 205 reported holders.
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 198 | $1.8B | 69,612,317 | 26 | 53 | 70 | 0.5% |
| Q1 2026 | 205 | $1.8B | 70,156,574 | 31 | 73 | 49 | 0.7% |
| Q4 2025 | 198 | $1.8B | 69,782,279 | 40 | 65 | 61 | 1.1% |
| Q3 2025 | 171 | $1.3B | 73,460,347 | 23 | 53 | 52 | 1.0% |
| Q2 2025 | 168 | $922.8M | 73,269,740 | 28 | 53 | 46 | 0.5% |
| Q1 2025 | 169 | $809.9M | 67,704,348 | 28 | 46 | 61 | 0.4% |
| Q4 2024 | 157 | $931.7M | 63,590,024 | 23 | 39 | 58 | 0.1% |
| Q3 2024 | 145 | $807.3M | 63,643,025 | 20 | 35 | 46 | 1.1% |
| Q2 2024 | 151 | $556.9M | 65,282,162 | 22 | 52 | 48 | 0.2% |
| Q1 2024 | 149 | $778.4M | 73,866,827 | 29 | 52 | 33 | 0.2% |
| Q4 2023 | 137 | $684.7M | 65,715,553 | 24 | 49 | 28 | 0.3% |
| Q3 2023 | 120 | $374.0M | 58,778,139 | 17 | 45 | 28 | 0.3% |
| Q2 2023 | 122 | $518.4M | 59,706,675 | 44 | 32 | 30 | 0.5% |
| Q1 2023 | 102 | $476.9M | 52,416,557 | 40 | 26 | 21 | 0.7% |
| Q4 2022 | 77 | $420.7M | 53,097,990 | 77 | 1 | 0 | 0.8% |
| Q3 2022 | 88 | $295.8M | 47,762,789 | 12 | 26 | 24 | 0.7% |
| Q2 2022 | 107 | $255.7M | 47,778,162 | 27 | 37 | 26 | 1.0% |
| Q1 2022 | 117 | $329.0M | 49,969,802 | 29 | 49 | 20 | 0.5% |
| Q4 2021 | 115 | $763.1M | 46,167,425 | 13 | 42 | 25 | 0.8% |
| Q3 2021 | 123 | $1.1B | 36,848,741 | 29 | 37 | 27 | 0.9% |
| Q2 2021 | 110 | $1.4B | 38,836,147 | 8 | 33 | 43 | 0.9% |
| Q1 2021 | 125 | $1.1B | 35,201,758 | 19 | 56 | 29 | 0.9% |
| Q4 2020 | 144 | $1.8B | 34,789,877 | 31 | 31 | 49 | 6.4% |
| Q3 2020 | 136 | $1.7B | 34,866,160 | 25 | 41 | 41 | 4.1% |
| Q2 2020 | 138 | $1.3B | 34,417,838 | 42 | 47 | 30 | 4.8% |
| Q1 2020 | 119 | $1.2B | 33,093,413 | 36 | 35 | 31 | 1.1% |
| Q4 2019 | 105 | $1.1B | 23,790,109 | 34 | 24 | 26 | 1.1% |
| Q3 2019 | 73 | $500.8M | 20,108,398 | 22 | 22 | 17 | 0.4% |
| Q2 2019 | 67 | $438.6M | 19,705,828 | 25 | 24 | 6 | 1.1% |
| Q1 2019 | 49 | $184.9M | 11,444,263 | 13 | 15 | 8 | 0.3% |
| Q4 2018 | 43 | $132.2M | 9,085,809 | 4 | 1 | 2 | 0.2% |