XENON PHARMACEUTICALS INC (XENE)
Institutional ownership reported to the SEC as of Q2 2026, across 31 quarters.
305
Reporting holders
$5.8B
Reported value
98.7%
Of shares outstanding
1.2%
Held as options
+24
Holder change
Institutions report 95,610,771 shares against 96,840,432 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $582.4M | 9,647,998 | 0.03% | 26q | -10.8%-$70.7M |
| BlackRock, Inc. | $454.1M | 7,522,482 | 0.01% | 8q | +33.4%+$113.6M |
| Avoro Capital Advisors LLC | $348.7M | 5,777,777 | 3.13% | 31q | HELD |
| Polar Capital Holdings Plc | $275.9M | 4,570,556 | 0.65% | 19q | +3.8%+$10.0M |
| Driehaus Capital Management LLC | $266.7M | 4,418,557 | 1.55% | 26q | -1.6%-$4.4M |
| Jupiter Topco LLC | $252.7M | 4,186,519 | 0.10% | new | FIRST |
| JPMORGAN CHASE & CO | $157.4M | 2,617,360 | 0.01% | 23q | +36.1%+$41.7M |
| Capital International Investors | $142.5M | 2,361,639 | 0.03% | 31q | -11.7%-$18.9M |
| STATE STREET CORP | $118.9M | 1,969,629 | 0.00% | 31q | +14.5%+$15.0M |
| TWO SIGMA INVESTMENTS, LP | $99.2M | 1,642,848 | 0.07% | 3q | +171.1%+$62.6M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $97.5M | 1,615,696 | 1.02% | 5q | HELD |
| Affinity Asset Advisors, LLC | $96.3M | 1,595,000 | 4.35% | 15q | -4.8%-$4.8M |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $91.0M | 1,507,294 | 0.30% | 11q | +7.5%+$6.4M |
| ALLIANCEBERNSTEIN L.P. | $90.8M | 1,562,276 | 0.03% | 21q | +11.3%+$9.2M |
| CITADEL ADVISORS LLC | $87.4M | 1,401,242 | 0.01% | 31q | -47.2%-$78.1M |
| FRANKLIN RESOURCES INC | $86.8M | 1,437,712 | 0.02% | 14q | +12.3%+$9.5M |
| WELLINGTON MANAGEMENT GROUP LLP | $86.0M | 1,425,492 | 0.01% | 14q | -70.5%-$205.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $82.7M | 1,370,114 | 0.00% | 31q | +25.4%+$16.7M |
| Siren, L.L.C. | $79.6M | 1,318,564 | 1.61% | 8q | HELD |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $77.9M | 1,290,731 | 0.08% | 10q | -3.8%-$3.1M |
| Pictet Asset Management Holding SA | $71.6M | 1,187,723 | 0.07% | 12q | +74.7%+$30.6M |
| BRAIDWELL LP | $68.3M | 1,131,452 | 2.53% | 15q | -15.5%-$12.5M |
| Nuveen, LLC | $59.9M | 993,126 | 0.01% | 5q | +297.2%+$44.9M |
| Invesco Ltd. | $54.5M | 903,458 | 0.00% | 14q | +1428.6%+$51.0M |
| ORBIMED ADVISORS LLC | $53.9M | 892,471 | 1.00% | 31q | -15.8%-$10.1M |
| Caligan Partners LP | $53.7M | 889,944 | 2.53% | 4q | -36.1%-$30.4M |
| AMERICAN CENTURY COMPANIES INC | $53.4M | 884,319 | 0.02% | 5q | +30.2%+$12.4M |
| FEDERATED HERMES, INC. | $53.3M | 883,737 | 0.08% | 11q | -9.1%-$5.3M |
| Capital World Investors | $52.1M | 862,775 | 0.01% | 31q | +2.7%+$1.4M |
| GOLDMAN SACHS GROUP INC | $46.7M | 773,625 | 0.00% | 25q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $45.2M | 749,651 | 0.00% | 2q | +38.0%+$12.5M |
| Caption Management, LLC | $43.9M | options only | 0.20% | 6q | OPTIONS |
| Vestal Point Capital, LP | $42.3M | 700,000 | 0.99% | 11q | +9.4%+$3.6M |
| Alyeska Investment Group, L.P. | $42.1M | 697,692 | 0.11% | 2q | -46.3%-$36.3M |
| MARSHALL WACE, LLP | $41.6M | 689,342 | 0.03% | new | NEW |
| Rock Springs Capital Management LP | $41.3M | 683,907 | 2.01% | 26q | -10.4%-$4.8M |
| NORTHERN TRUST CORP | $40.5M | 671,566 | 0.00% | 31q | +27.2%+$8.7M |
| PANAGORA ASSET MANAGEMENT INC | $40.1M | 664,031 | 0.12% | new | NEW |
| First Turn Management, LLC | $36.2M | 600,200 | 3.88% | 11q | -23.7%-$11.3M |
| TUDOR INVESTMENT CORP ET AL | $32.9M | 545,387 | 0.05% | 4q | +10.0%+$3.0M |
| LOOMIS SAYLES & CO L P | $31.8M | 527,273 | 0.04% | 15q | -6.7%-$2.3M |
| Octagon Capital Advisors LP | $29.6M | 490,000 | 2.66% | 2q | HELD |
| NOVO HOLDINGS A/S | $29.3M | 485,438 | 1.70% | 2q | HELD |
| Candriam S.C.A. | $27.9M | 462,768 | 0.13% | 21q | -2.9%-$827.7K |
| TimesSquare Capital Management, LLC | $27.3M | 451,593 | 0.40% | 15q | +25.7%+$5.6M |
| Logos Global Management LP | $27.2M | 450,000 | 1.17% | 2q | HELD |
| Trails Edge Capital Partners, LP | $26.6M | 440,000 | 4.22% | 3q | HELD |
| Bank of New York Mellon Corp | $25.4M | 421,518 | 0.00% | 29q | +6.4%+$1.5M |
| ALGERT GLOBAL LLC | $25.3M | 419,773 | 0.30% | 18q | -20.6%-$6.6M |
| Aberdeen Group plc | $24.7M | 408,736 | 0.03% | 11q | -33.0%-$12.1M |
| MORGAN STANLEY | $24.5M | 406,257 | 0.00% | 35q | -14.2%-$4.1M |
| Fiera Capital Corp | $24.5M | 405,638 | 0.09% | 13q | -42.8%-$18.3M |
| BANK OF AMERICA CORP /DE/ | $24.4M | 404,067 | 0.00% | 25q | +52.3%+$8.4M |
| Parkman Healthcare Partners LLC | $24.0M | 397,379 | 2.46% | 27q | -20.1%-$6.0M |
| Nicholas Investment Partners, LP | $23.9M | 395,844 | 1.35% | 8q | +60.2%+$9.0M |
| MILLENNIUM MANAGEMENT LLC | $22.7M | 376,777 | 0.01% | 27q | +86.7%+$10.6M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $22.6M | 374,748 | 0.00% | 3q | HELD |
| BAKER BROS. ADVISORS LP | $22.3M | 370,208 | 0.11% | 25q | HELD |
| Jones Hill Capital LP | $22.2M | 367,900 | 4.72% | new | NEW |
| AMERIPRISE FINANCIAL INC | $19.2M | 318,548 | 0.00% | 8q | +101.9%+$9.7M |
| Man Group plc | $18.7M | 310,617 | 0.03% | new | NEW |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $18.1M | 300,000 | 0.03% | 31q | -36.2%-$10.3M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $17.2M | 22,258 | 0.00% | 22q | -87.4%-$119.4M |
| Soleus Capital Management, L.P. | $16.1M | 267,000 | 0.56% | 2q | -8.6%-$1.5M |
| Jump Financial, LLC | $15.7M | 260,730 | 0.13% | 5q | +67.4%+$6.3M |
| DAFNA Capital Management LLC | $15.1M | 250,772 | 2.89% | 31q | HELD |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $15.1M | 249,473 | 0.00% | 5q | +31.9%+$3.6M |
| Sixth Street Partners Management Company, L.P. | $15.1M | 249,473 | 0.00% | new | NEW |
| STATE OF WISCONSIN INVESTMENT BOARD | $15.0M | 248,821 | 0.03% | 18q | -2.2%-$341.8K |
| NAN FUNG TRINITY (HK) LTD | $15.0M | 247,765 | 1.48% | 5q | HELD |
| Allspring Global Investments Holdings, LLC | $14.1M | 234,412 | 0.02% | 2q | -4.8%-$717.2K |
| Redmile Group, LLC | $13.8M | 229,374 | 0.93% | 3q | -12.7%-$2.0M |
| Schonfeld Strategic Advisors LLC | $13.7M | 227,330 | 0.05% | 2q | -30.0%-$5.9M |
| D. E. Shaw & Co., Inc. | $13.5M | 223,922 | 0.01% | 31q | +1082.3%+$12.4M |
| Patient Square Capital LP | $13.3M | 220,000 | 2.06% | 3q | -3.1%-$422.5K |
| NEW YORK STATE COMMON RETIREMENT FUND | $12.7M | 210,471 | 0.02% | 19q | +11.7%+$1.3M |
| JENNISON ASSOCIATES LLC | $12.6M | 208,060 | 0.01% | 13q | -84.2%-$67.0M |
| NEUBERGER BERMAN GROUP LLC | $12.5M | 206,604 | 0.01% | 7q | +58.4%+$4.6M |
| Trexquant Investment LP | $12.2M | 202,455 | 0.07% | 2q | +200.6%+$8.2M |
| DNB Asset Management AS | $12.1M | 200,451 | 0.03% | 15q | +10.7%+$1.2M |
| Integral Health Asset Management, LLC | $12.1M | 200,000 | 0.48% | 2q | HELD |
| Eversept Partners, LP | $11.9M | 196,532 | 0.62% | 3q | +51.7%+$4.0M |
| Balyasny Asset Management L.P. | $11.7M | 193,407 | 0.01% | 11q | -17.3%-$2.4M |
| DEUTSCHE BANK AG\ | $11.5M | 191,126 | 0.00% | 15q | +17.5%+$1.7M |
| RENAISSANCE TECHNOLOGIES LLC | $11.3M | 187,110 | 0.02% | 2q | -37.7%-$6.8M |
| SILVERARC CAPITAL MANAGEMENT, LLC | $11.3M | 186,821 | 1.17% | 2q | -5.5%-$660.2K |
| BOOTHBAY FUND MANAGEMENT, LLC | $11.1M | 183,343 | 0.15% | 4q | -32.2%-$5.3M |
| NEXTBio Capital Management LP | $11.1M | 183,225 | 5.09% | 3q | HELD |
| WELLS FARGO & COMPANY/MN | $10.5M | 173,945 | 0.00% | 16q | -24.8%-$3.5M |
| ADAR1 Capital Management, LLC | $10.1M | 166,550 | 0.46% | 9q | -27.2%-$3.8M |
| PEREGRINE CAPITAL MANAGEMENT LLC | $10.0M | 164,894 | 0.32% | 3q | +15.2%+$1.3M |
| Swiss National Bank | $9.8M | 162,700 | 0.01% | 25q | +3.2%+$301.8K |
| Foresite Capital Management IV, LLC | $9.7M | 160,000 | 3.33% | 5q | HELD |
| Woodline Partners LP | $9.4M | 155,302 | 0.03% | 2q | +3.3%+$301.8K |
| Palo Alto Investors LP | $9.3M | 154,035 | 0.43% | 3q | +200.0%+$6.2M |
| Russell Investments Group, Ltd. | $9.2M | 153,227 | 0.01% | 19q | +18.4%+$1.4M |
| HSBC HOLDINGS PLC | $9.1M | 151,474 | 0.00% | 2q | +24.6%+$1.8M |
| Susquehanna Portfolio Strategies, LLC | $8.0M | 133,059 | 0.13% | 2q | +620.5%+$6.9M |
| Point72 Asset Management, L.P. | $7.9M | 130,378 | 0.01% | 3q | HELD |
| Granahan Investment Management, LLC | $7.8M | 129,443 | 0.28% | 30q | +23.9%+$1.5M |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-13 | 13G/A | Wellington Management Group LLPwith 2 co-filers | 1.5% |
| 2026-08-07 | 13G/A | FMR LLCwith 1 co-filers | 10.3% |
| 2026-08-06 | 13G/A | FMR LLCwith 1 co-filers | 9.9% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 305 | $5.8B | 95,610,771 | 47 | 116 | 83 | 1.2% |
| Q1 2026 | 281 | $5.9B | 98,151,950 | 69 | 118 | 54 | 4.4% |
| Q4 2025 | 237 | $3.8B | 82,118,180 | 47 | 69 | 69 | 2.3% |
| Q3 2025 | 207 | $3.4B | 84,315,620 | 34 | 61 | 68 | 0.7% |
| Q2 2025 | 192 | $2.6B | 82,452,796 | 40 | 71 | 49 | 0.8% |
| Q1 2025 | 195 | $2.5B | 74,388,882 | 22 | 60 | 64 | 0.9% |
| Q4 2024 | 192 | $2.9B | 73,226,167 | 22 | 57 | 59 | 0.1% |
| Q3 2024 | 181 | $2.9B | 72,622,958 | 11 | 59 | 54 | 0.2% |
| Q2 2024 | 191 | $2.8B | 71,578,699 | 18 | 65 | 59 | 0.4% |
| Q1 2024 | 200 | $3.0B | 69,807,455 | 30 | 72 | 57 | 1.0% |
| Q4 2023 | 190 | $3.2B | 69,067,713 | 40 | 78 | 43 | 2.3% |
| Q3 2023 | 164 | $2.0B | 58,314,132 | 18 | 63 | 44 | 1.4% |
| Q2 2023 | 159 | $2.2B | 57,455,713 | 31 | 48 | 50 | 0.4% |
| Q1 2023 | 140 | $2.2B | 61,404,001 | 25 | 44 | 37 | 0.5% |
| Q4 2022 | 130 | $2.1B | 52,035,869 | 18 | 48 | 36 | 0.8% |
| Q3 2022 | 154 | $2.1B | 58,315,780 | 25 | 58 | 43 | 0.4% |
| Q2 2022 | 153 | $1.7B | 57,200,640 | 38 | 56 | 39 | 0.3% |
| Q1 2022 | 137 | $1.5B | 49,368,181 | 18 | 49 | 41 | 0.4% |
| Q4 2021 | 135 | $1.6B | 50,101,327 | 31 | 50 | 29 | 1.0% |
| Q3 2021 | 123 | $574.3M | 34,109,938 | 32 | 33 | 29 | 9.2% |
| Q2 2021 | 103 | $707.2M | 35,251,558 | 16 | 27 | 30 | 0.6% |
| Q1 2021 | 92 | $593.1M | 32,964,320 | 16 | 32 | 24 | 0.5% |
| Q4 2020 | 81 | $430.9M | 28,020,796 | 9 | 21 | 21 | 0.0% |
| Q3 2020 | 78 | $309.2M | 27,925,170 | 4 | 13 | 25 | 0.0% |
| Q2 2020 | 79 | $351.0M | 27,992,534 | 19 | 23 | 9 | 0.0% |
| Q1 2020 | 72 | $314.0M | 27,710,944 | 18 | 20 | 20 | 0.0% |
| Q4 2019 | 68 | $245.7M | 18,724,038 | 13 | 19 | 14 | 0.1% |
| Q3 2019 | 55 | $145.0M | 16,095,757 | 4 | 9 | 18 | 0.0% |
| Q2 2019 | 60 | $173.2M | 17,563,270 | 9 | 18 | 11 | 0.0% |
| Q1 2019 | 63 | $180.2M | 17,736,961 | 9 | 23 | 16 | 0.0% |
| Q4 2018 | 59 | $110.2M | 17,466,358 | 1 | 2 | 1 | 0.0% |