UPSTREAM BIO INC (UPB)
Institutional ownership reported to the SEC as of Q2 2026, across 7 quarters.
147
Reporting holders
$349.1M
Reported value
92.0%
Of shares outstanding
0.1%
Held as options
+6
Holder change
Institutions report 50,383,867 shares against 54,771,041 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $56.5M | 8,162,897 | 0.00% | 7q | +0.8%+$424.4K |
| ORBIMED ADVISORS LLC | $39.4M | 5,693,589 | 0.73% | 7q | HELD |
| NORGES BANK | $26.1M | 3,768,619 | 0.00% | 5q | +30.7%+$6.1M |
| BlackRock, Inc. | $26.0M | 3,753,358 | 0.00% | 7q | +11.4%+$2.6M |
| Decheng Capital LLC | $18.9M | 2,724,868 | 2.58% | 7q | HELD |
| ENAVATE SCIENCES GP, LLC | $17.0M | 2,459,703 | 4.93% | 7q | HELD |
| VANGUARD CAPITAL MANAGEMENT LLC | $13.0M | 1,876,734 | 0.00% | 2q | HELD |
| MILLENNIUM MANAGEMENT LLC | $7.9M | 1,143,775 | 0.00% | 4q | +22.0%+$1.4M |
| D. E. Shaw & Co., Inc. | $7.2M | 1,036,044 | 0.00% | 3q | +26.3%+$1.5M |
| JPMORGAN CHASE & CO | $7.0M | 1,012,044 | 0.00% | 7q | +118.6%+$3.8M |
| Qube Research & Technologies Ltd | $6.8M | 978,500 | 0.01% | 2q | +58.0%+$2.5M |
| Parkman Healthcare Partners LLC | $6.5M | 935,247 | 0.66% | 6q | +18.9%+$1.0M |
| GEODE CAPITAL MANAGEMENT, LLC | $6.4M | 931,261 | 0.00% | 7q | -2.0%-$134.0K |
| SEB Asset Management AB | $6.1M | 878,473 | 0.02% | 2q | HELD |
| Woodline Partners LP | $5.8M | 831,481 | 0.02% | 7q | HELD |
| STATE STREET CORP | $5.3M | 766,323 | 0.00% | 7q | +8.6%+$421.9K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4.9M | 712,667 | 0.00% | 2q | -2.1%-$104.1K |
| Y-Intercept (Hong Kong) Ltd | $4.8M | 693,555 | 0.09% | 3q | -30.7%-$2.1M |
| Bain Capital Life Sciences Investors, LLC | $4.2M | 600,949 | 0.25% | 7q | -30.7%-$1.8M |
| AQR CAPITAL MANAGEMENT LLC | $3.8M | 544,869 | 0.00% | 6q | +655.0%+$3.3M |
| MORGAN STANLEY | $3.6M | 524,632 | 0.00% | 7q | -5.1%-$193.6K |
| BNP PARIBAS FINANCIAL MARKETS | $3.5M | 511,546 | 0.00% | 7q | +306.0%+$2.7M |
| Walleye Capital LLC | $3.4M | 498,490 | 0.01% | new | NEW |
| Trexquant Investment LP | $3.2M | 466,430 | 0.02% | 3q | +164.0%+$2.0M |
| Point72 Asset Management, L.P. | $3.1M | 453,011 | 0.00% | 3q | +154.3%+$1.9M |
| BANK OF AMERICA CORP /DE/ | $2.7M | 391,762 | 0.00% | 7q | +708.4%+$2.4M |
| DIMENSIONAL FUND ADVISORS LP | $2.6M | 381,613 | 0.00% | 2q | +377.0%+$2.1M |
| Altshuler Shaham Ltd | $2.6M | 380,061 | 0.03% | 6q | HELD |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2.5M | 357,756 | 0.00% | 2q | +93.3%+$1.2M |
| SAMSARA BIOCAPITAL, LLC | $2.4M | 353,717 | 0.20% | 7q | -51.9%-$2.6M |
| Propel Bio Management, LLC | $2.4M | 350,389 | 1.27% | 2q | +2.5%+$59.6K |
| WELLINGTON MANAGEMENT GROUP LLP | $2.4M | 342,353 | 0.00% | 7q | HELD |
| NORTHERN TRUST CORP | $2.1M | 297,346 | 0.00% | 7q | +13.9%+$251.6K |
| Squarepoint Ops LLC | $2.0M | 290,904 | 0.00% | 2q | +551.9%+$1.7M |
| Voleon Capital Management LP | $2.0M | 285,234 | 0.04% | new | NEW |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1.8M | 262,456 | 0.00% | 7q | +1.8%+$32.7K |
| Sixth Street Partners Management Company, L.P. | $1.8M | 262,456 | 0.00% | new | NEW |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1.8M | 253,092 | 0.01% | new | NEW |
| GOLDMAN SACHS GROUP INC | $1.7M | 246,917 | 0.00% | 4q | -22.0%-$482.1K |
| XTX Topco Ltd | $1.7M | 242,346 | 0.02% | 3q | +15.8%+$228.8K |
| DEUTSCHE BANK AG\ | $1.7M | 241,447 | 0.00% | 7q | +33.5%+$419.1K |
| VANGUARD FIDUCIARY TRUST CO | $1.7M | 239,616 | 0.00% | 2q | +6.9%+$107.0K |
| UBS Group AG | $1.6M | 234,714 | 0.00% | 7q | +1.5%+$23.9K |
| Schonfeld Strategic Advisors LLC | $1.6M | 225,760 | 0.01% | 6q | +39.9%+$445.7K |
| Jump Financial, LLC | $1.5M | 223,223 | 0.01% | 2q | -30.1%-$665.5K |
| SPHERA FUNDS MANAGEMENT LTD. | $1.5M | 219,700 | 0.20% | 2q | -38.6%-$957.0K |
| Boxer Capital Management, LLC | $1.0M | 150,000 | 0.08% | 3q | HELD |
| RENAISSANCE TECHNOLOGIES LLC | $908.6K | 131,300 | 0.00% | 3q | +111.4%+$478.9K |
| EntryPoint Capital, LLC | $895.8K | 129,446 | 0.22% | 2q | +76.0%+$386.7K |
| ALGERT GLOBAL LLC | $820.9K | 118,630 | 0.01% | new | NEW |
| Bank of New York Mellon Corp | $593.4K | 85,747 | 0.00% | 7q | +5.4%+$30.2K |
| Nuveen, LLC | $586.6K | 84,770 | 0.00% | 6q | +12.2%+$63.9K |
| AMERICAN CENTURY COMPANIES INC | $541.1K | 78,194 | 0.00% | 5q | -10.8%-$65.3K |
| Man Group plc | $510.9K | 73,823 | 0.00% | 2q | +249.0%+$364.5K |
| ALLIANCEBERNSTEIN L.P. | $465.1K | 51,680 | 0.00% | 7q | +66.7%+$186.0K |
| Stonepine Capital Management, LLC | $462.7K | 66,864 | 0.12% | 2q | +91.0%+$220.5K |
| Simplify Asset Management Inc. | $429.8K | 62,113 | 0.01% | 2q | -20.2%-$108.5K |
| ALPS ADVISORS INC | $382.2K | 55,228 | 0.00% | 7q | +25.5%+$77.8K |
| Quantinno Capital Management LP | $379.5K | 54,838 | 0.00% | 6q | +11.0%+$37.7K |
| Virtus Investment Advisers, LLC | $371.2K | 53,638 | 0.09% | 5q | +433.9%+$301.7K |
| Invesco Ltd. | $369.5K | 53,397 | 0.00% | 7q | +31.8%+$89.2K |
| Brevan Howard Capital Management LP | $348.6K | 50,369 | 0.00% | new | NEW |
| Swiss National Bank | $332.9K | 48,100 | 0.00% | 3q | HELD |
| Russell Investments Group, Ltd. | $329.0K | 47,543 | 0.00% | 5q | +1203.6%+$303.8K |
| Allspring Global Investments Holdings, LLC | $298.8K | 43,182 | 0.00% | new | NEW |
| RHUMBLINE ADVISERS | $293.3K | 42,384 | 0.00% | 7q | +2.9%+$8.2K |
| TWO SIGMA INVESTMENTS, LP | $292.9K | 42,325 | 0.00% | new | NEW |
| ExodusPoint Capital Management, LP | $284.0K | 41,045 | 0.00% | 3q | -55.1%-$348.7K |
| CITIGROUP INC | $279.1K | 40,339 | 0.00% | 7q | +698.0%+$244.2K |
| Mariner, LLC | $229.3K | 33,141 | 0.00% | 4q | +21.3%+$40.3K |
| WELLS FARGO & COMPANY/MN | $204.1K | 29,497 | 0.00% | 7q | -19.9%-$50.6K |
| BARCLAYS PLC | $202.1K | 29,208 | 0.00% | 7q | +18.2%+$31.1K |
| Creative Planning | $197.1K | 28,483 | 0.00% | 5q | +162.5%+$122.0K |
| Quantbot Technologies LP | $195.0K | 28,178 | 0.01% | 2q | +4150.1%+$190.4K |
| JANE STREET GROUP, LLC | $190.3K | 15,594 | 0.00% | 2q | HELD |
| AXQ CAPITAL, LP | $187.3K | 27,068 | 0.02% | 2q | -1.6%-$3.0K |
| MERCER GLOBAL ADVISORS INC /ADV | $184.8K | 26,704 | 0.00% | new | NEW |
| nVerses Capital, LLC | $166.3K | 24,029 | 0.26% | new | NEW |
| DNB Asset Management AS | $163.3K | 23,600 | 0.00% | 3q | HELD |
| VANGUARD ASSET MANAGEMENT, Ltd | $157.2K | 22,724 | 0.00% | 2q | +145.7%+$93.2K |
| Graham Capital Management, L.P. | $155.8K | 22,508 | 0.00% | new | NEW |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $154.9K | 22,385 | 0.00% | new | NEW |
| Verdad Advisers, LP | $150.9K | 21,810 | 0.14% | new | NEW |
| MetLife Investment Management, LLC | $144.3K | 20,852 | 0.00% | 7q | +7.6%+$10.2K |
| SEI INVESTMENTS CO | $138.6K | 20,026 | 0.00% | new | NEW |
| WINTON GROUP Ltd | $137.0K | 19,800 | 0.00% | new | NEW |
| IEQ CAPITAL, LLC | $135.2K | 19,535 | 0.00% | new | NEW |
| DIADEMA PARTNERS LP | $132.1K | 19,093 | 0.02% | 4q | -11.6%-$17.4K |
| Shay Capital LLC | $124.6K | 18,000 | 0.01% | 2q | +80.0%+$55.4K |
| Quadrature Capital Ltd | $124.5K | 17,988 | 0.00% | new | NEW |
| Entropy Technologies, LP | $121.4K | 17,542 | 0.00% | 2q | -24.8%-$40.1K |
| STATE OF WISCONSIN INVESTMENT BOARD | $118.1K | 17,065 | 0.00% | 2q | -59.0%-$170.3K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $112.2K | 16,217 | 0.00% | 7q | +3.9%+$4.2K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $108.9K | 15,735 | 0.00% | 5q | +2.6%+$2.7K |
| CITADEL ADVISORS LLC | $103.8K | options only | 0.00% | 4q | OPTIONS |
| Vanguard Global Advisers, LLC | $90.4K | 13,059 | 0.00% | 2q | HELD |
| Legal & General Group Plc | $86.9K | 12,561 | 0.00% | 7q | +30.7%+$20.4K |
| Engineers Gate Manager LP | $86.4K | 12,491 | 0.00% | new | NEW |
| STRS OHIO | $83.0K | 12,000 | 0.00% | 3q | +22.4%+$15.2K |
| CANADA PENSION PLAN INVESTMENT BOARD | $79.6K | 11,500 | 0.00% | new | NEW |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-12 | 13G/A | Norges Bank | 7.7% |
| 2026-07-30 | 13G | BlackRock, Inc. | 5.2% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 147 | $349.1M | 50,383,867 | 34 | 62 | 28 | 0.1% |
| Q1 2026 | 141 | $405.9M | 44,842,065 | 39 | 46 | 34 | 0.5% |
| Q4 2025 | 129 | $1.4B | 51,134,333 | 36 | 38 | 32 | 0.2% |
| Q3 2025 | 97 | $844.5M | 44,453,824 | 31 | 34 | 21 | 1.0% |
| Q2 2025 | 79 | $530.6M | 48,319,984 | 11 | 39 | 13 | 0.0% |
| Q1 2025 | 77 | $266.9M | 46,277,103 | 22 | 11 | 25 | 0.0% |
| Q4 2024 | 68 | $690.0M | 42,066,408 | 65 | 0 | 0 | 0.0% |