TYRA BIOSCIENCES INC (TYRA)
Institutional ownership reported to the SEC as of Q2 2026, across 20 quarters.
167
Reporting holders
$2.1B
Reported value
111.8%
Of shares outstanding
0.7%
Held as options
+5
Holder change
Institutions report 66,727,315 shares against 59,676,939 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $389.6M | 12,198,625 | 3.39% | 20q | HELD |
| FMR LLC | $284.9M | 8,920,513 | 0.01% | 20q | +15.1%+$37.5M |
| Jupiter Topco LLC | $139.2M | 4,352,448 | 0.06% | new | FIRST |
| Alta Partners Management Company, L.P. | $122.1M | 3,823,425 | 95.92% | 7q | HELD |
| Nextech Invest Ltd. | $113.5M | 3,553,585 | 5.39% | 6q | -12.4%-$16.0M |
| TCG Crossover Management, LLC | $103.8M | 3,248,980 | 2.49% | 19q | HELD |
| BlackRock, Inc. | $96.8M | 3,031,972 | 0.00% | 8q | +36.7%+$26.0M |
| STATE STREET CORP | $68.4M | 2,140,368 | 0.00% | 19q | +76.0%+$29.5M |
| Commodore Capital LP | $59.9M | 1,875,000 | 3.57% | 6q | -24.2%-$19.2M |
| Paradigm Biocapital Advisors LP | $58.4M | 1,828,607 | 1.09% | 2q | -11.0%-$7.2M |
| VANGUARD CAPITAL MANAGEMENT LLC | $48.2M | 1,508,447 | 0.00% | 2q | +34.0%+$12.2M |
| BVF INC/IL | $47.1M | 1,476,196 | 1.21% | 20q | -25.3%-$16.0M |
| 5AM Venture Management, LLC | $32.9M | 1,029,298 | 11.42% | 12q | HELD |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $32.5M | 1,017,000 | 0.34% | 2q | +85.2%+$14.9M |
| Hood River Capital Management LLC | $32.5M | 1,016,775 | 0.24% | new | NEW |
| GEODE CAPITAL MANAGEMENT, LLC | $31.0M | 970,734 | 0.00% | 19q | +47.4%+$10.0M |
| Caligan Partners LP | $25.8M | 806,986 | 1.21% | 6q | -36.8%-$15.0M |
| Canaan Partners XI LLC | $24.0M | 750,000 | 18.82% | 19q | HELD |
| Siren, L.L.C. | $23.2M | 725,000 | 0.47% | new | NEW |
| Sio Capital Management, LLC | $22.2M | 695,315 | 3.68% | 10q | +14.8%+$2.9M |
| STEMPOINT CAPITAL LP | $20.2M | 632,754 | 3.48% | 2q | +63.8%+$7.9M |
| MARSHALL WACE, LLP | $18.6M | 583,133 | 0.01% | 8q | +194.9%+$12.3M |
| GOLDMAN SACHS GROUP INC | $14.8M | 463,477 | 0.00% | 10q | -15.8%-$2.8M |
| JENNISON ASSOCIATES LLC | $14.4M | 450,964 | 0.01% | 2q | -28.7%-$5.8M |
| TWO SIGMA INVESTMENTS, LP | $14.4M | 449,808 | 0.01% | 10q | +342.6%+$11.1M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12.9M | 403,019 | 0.00% | 2q | +63.0%+$5.0M |
| Defilade Capital Management, L.P. | $12.0M | 376,870 | 1.61% | new | NEW |
| BANK OF AMERICA CORP /DE/ | $11.2M | 349,732 | 0.00% | 20q | +66.6%+$4.5M |
| Walleye Capital LLC | $11.1M | 347,898 | 0.04% | 2q | +1758.9%+$10.5M |
| Woodline Partners LP | $10.2M | 320,040 | 0.03% | 2q | +6.3%+$606.9K |
| NORTHERN TRUST CORP | $9.9M | 310,084 | 0.00% | 19q | +41.9%+$2.9M |
| MORGAN STANLEY | $9.6M | 300,322 | 0.00% | 19q | +149.3%+$5.7M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9.6M | options only | 0.00% | 3q | OPTIONS |
| CITADEL ADVISORS LLC | $8.9M | 278,307 | 0.00% | 8q | +1707.7%+$8.4M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $8.6M | 267,699 | 0.00% | 19q | +34.4%+$2.2M |
| Sixth Street Partners Management Company, L.P. | $8.6M | 267,699 | 0.00% | new | NEW |
| Qube Research & Technologies Ltd | $8.5M | 266,934 | 0.01% | new | NEW |
| BNP PARIBAS FINANCIAL MARKETS | $7.7M | 240,227 | 0.00% | 7q | +26.4%+$1.6M |
| ALGERT GLOBAL LLC | $7.6M | 239,120 | 0.09% | 3q | -36.4%-$4.4M |
| VANGUARD FIDUCIARY TRUST CO | $7.2M | 224,805 | 0.00% | 2q | +42.5%+$2.1M |
| DIMENSIONAL FUND ADVISORS LP | $6.9M | 217,078 | 0.00% | 8q | +136.4%+$4.0M |
| MILLENNIUM MANAGEMENT LLC | $6.5M | 177,672 | 0.00% | 8q | -19.8%-$1.6M |
| Affinity Asset Advisors, LLC | $6.4M | 200,012 | 0.29% | 2q | -22.3%-$1.8M |
| FRANKLIN RESOURCES INC | $6.1M | 192,340 | 0.00% | 3q | +1383.0%+$5.7M |
| HighVista Strategies LLC | $5.9M | 184,774 | 1.35% | 9q | +40.7%+$1.7M |
| RAYMOND JAMES FINANCIAL INC | $5.8M | 180,881 | 0.00% | 7q | -26.8%-$2.1M |
| JPMORGAN CHASE & CO | $5.7M | 178,263 | 0.00% | 19q | +166.9%+$3.6M |
| BOOTHBAY FUND MANAGEMENT, LLC | $5.5M | 173,559 | 0.07% | 4q | -36.5%-$3.2M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $5.2M | 162,000 | 0.01% | new | NEW |
| Jump Financial, LLC | $5.0M | 157,000 | 0.04% | 2q | +279.5%+$3.7M |
| VICTORY CAPITAL MANAGEMENT INC | $4.9M | 152,585 | 0.00% | 14q | +901.9%+$4.4M |
| Kalehua Capital Management LLC | $4.8M | 148,930 | 1.52% | 3q | HELD |
| Ensign Peak Advisors, Inc | $4.7M | 146,537 | 0.01% | 2q | -1.1%-$50.8K |
| BARCLAYS PLC | $4.3M | 20,275 | 0.00% | 18q | -97.6%-$171.6M |
| Trexquant Investment LP | $4.2M | 132,740 | 0.02% | 2q | -9.9%-$465.6K |
| UBS Group AG | $4.2M | 129,945 | 0.00% | 16q | +111.1%+$2.2M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $3.9M | 123,420 | 0.00% | 3q | -4.2%-$173.8K |
| Bank of New York Mellon Corp | $3.3M | 103,720 | 0.00% | 19q | +43.6%+$1.0M |
| Russell Investments Group, Ltd. | $3.3M | 102,703 | 0.00% | 13q | +45.8%+$1.0M |
| ORBIMED ADVISORS LLC | $3.3M | 102,000 | 0.06% | new | NEW |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2.8M | 89,205 | 0.01% | 7q | -45.0%-$2.3M |
| OPPENHEIMER & CO INC | $2.7M | 83,783 | 0.03% | 10q | HELD |
| XTX Topco Ltd | $2.6M | 81,320 | 0.03% | 5q | -3.1%-$82.3K |
| Nuveen, LLC | $2.5M | 78,829 | 0.00% | 6q | +55.1%+$894.0K |
| SEI INVESTMENTS CO | $2.1M | 66,607 | 0.00% | new | NEW |
| Squarepoint Ops LLC | $2.0M | 63,805 | 0.00% | 5q | +211.3%+$1.4M |
| CITIGROUP INC | $2.0M | 62,279 | 0.00% | 13q | +939.5%+$1.8M |
| Fisher Asset Management, LLC | $1.9M | 60,230 | 0.00% | 3q | +109.1%+$1.0M |
| ALPS ADVISORS INC | $1.9M | 60,159 | 0.01% | 5q | +37.2%+$520.7K |
| WELLINGTON MANAGEMENT GROUP LLP | $1.9M | 59,601 | 0.00% | 20q | -22.8%-$561.1K |
| ALLIANCEBERNSTEIN L.P. | $1.9M | 48,420 | 0.00% | 9q | +51.4%+$629.3K |
| RHUMBLINE ADVISERS | $1.7M | 52,039 | 0.00% | 18q | +31.2%+$395.4K |
| TD Asset Management Inc | $1.6M | 50,000 | 0.00% | 2q | HELD |
| Arkadios Wealth Advisors | $1.6M | 49,336 | 0.02% | 2q | +3.7%+$56.5K |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.5M | 46,697 | 0.00% | 9q | +40.4%+$429.2K |
| JANE STREET GROUP, LLC | $1.4M | options only | 0.00% | 2q | OPTIONS |
| Susquehanna Portfolio Strategies, LLC | $1.4M | 44,878 | 0.02% | 5q | -4.6%-$68.6K |
| Swiss National Bank | $1.4M | 44,700 | 0.00% | 2q | +69.3%+$584.5K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1.4M | 44,327 | 0.00% | 3q | +10.2%+$131.0K |
| ExodusPoint Capital Management, LP | $1.3M | 41,026 | 0.01% | 3q | +191.7%+$861.1K |
| Rafferty Asset Management, LLC | $1.2M | 38,702 | 0.00% | 3q | +11.0%+$122.8K |
| DEUTSCHE BANK AG\ | $1.2M | 36,935 | 0.00% | 19q | +80.2%+$525.1K |
| Verdad Advisers, LP | $1.1M | 36,003 | 1.10% | new | NEW |
| WELLS FARGO & COMPANY/MN | $1.1M | 33,561 | 0.00% | 14q | +43.8%+$326.3K |
| Sofinnova Investments, Inc. | $1.0M | 32,267 | 0.05% | 2q | -84.2%-$5.5M |
| Engineers Gate Manager LP | $1.0M | 31,958 | 0.01% | new | NEW |
| AQR CAPITAL MANAGEMENT LLC | $953.5K | 29,853 | 0.00% | 5q | +1.5%+$13.7K |
| Tidal Investments LLC | $942.8K | 29,519 | 0.00% | new | NEW |
| Tema ETFs LLC | $942.8K | 29,519 | 0.03% | new | NEW |
| PDT Partners, LLC | $820.3K | 25,684 | 0.04% | 5q | -39.3%-$530.2K |
| Invesco Ltd. | $795.1K | 24,893 | 0.00% | 4q | -77.2%-$2.7M |
| STRS OHIO | $705.9K | 22,100 | 0.00% | 10q | +22.1%+$127.8K |
| Creative Planning | $696.4K | 21,803 | 0.00% | 3q | -9.0%-$68.5K |
| MetLife Investment Management, LLC | $693.8K | 21,723 | 0.00% | 14q | +55.2%+$246.9K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $683.1K | 21,364 | 0.00% | 9q | +46.1%+$215.5K |
| LMR Partners LLP | $675.6K | 21,151 | 0.00% | new | NEW |
| Auour Investments LLC | $671.4K | 21,020 | 0.19% | 13q | HELD |
| VOYA INVESTMENT MANAGEMENT LLC | $647.8K | 20,282 | 0.00% | 3q | -47.1%-$577.3K |
| D. E. Shaw & Co., Inc. | $644.8K | 20,189 | 0.00% | new | NEW |
| Vanguard Global Advisers, LLC | $643.7K | 20,154 | 0.00% | 2q | +30.2%+$149.3K |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | Farallon Capital Management, L.L.C.with 28 co-filers | 0.0% |
| 2026-08-14 | 13G/A | Nextech VI Oncology SCSpwith 4 co-filers | 6.0% |
| 2026-07-30 | 13G | BlackRock, Inc. | 5.0% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 167 | $2.1B | 66,727,315 | 31 | 67 | 45 | 0.7% |
| Q1 2026 | 162 | $2.5B | 65,634,146 | 38 | 57 | 34 | 0.6% |
| Q4 2025 | 130 | $1.5B | 56,727,738 | 23 | 39 | 37 | 0.0% |
| Q3 2025 | 112 | $780.3M | 55,750,118 | 8 | 38 | 35 | 0.0% |
| Q2 2025 | 116 | $541.6M | 56,594,107 | 18 | 59 | 19 | 0.0% |
| Q1 2025 | 111 | $499.6M | 53,554,795 | 18 | 38 | 30 | 0.1% |
| Q4 2024 | 109 | $675.8M | 48,603,457 | 27 | 33 | 24 | 0.0% |
| Q3 2024 | 92 | $1.1B | 47,408,437 | 24 | 27 | 20 | 0.7% |
| Q2 2024 | 74 | $751.4M | 46,994,255 | 14 | 29 | 15 | 0.0% |
| Q1 2024 | 72 | $770.5M | 46,975,408 | 18 | 26 | 14 | 0.0% |
| Q4 2023 | 65 | $502.8M | 36,192,622 | 10 | 19 | 8 | 0.3% |
| Q3 2023 | 56 | $501.8M | 36,442,086 | 3 | 14 | 16 | 0.0% |
| Q2 2023 | 56 | $506.8M | 29,760,205 | 7 | 17 | 14 | 0.0% |
| Q1 2023 | 44 | $519.3M | 32,275,391 | 8 | 16 | 7 | 0.1% |
| Q4 2022 | 40 | $264.1M | 34,743,962 | 0 | 15 | 9 | 0.0% |
| Q3 2022 | 48 | $319.8M | 36,375,322 | 6 | 15 | 14 | 0.0% |
| Q2 2022 | 45 | $255.6M | 35,744,386 | 3 | 18 | 15 | 0.0% |
| Q1 2022 | 46 | $386.6M | 36,133,976 | 5 | 12 | 17 | 0.0% |
| Q4 2021 | 45 | $503.6M | 35,847,719 | 25 | 8 | 6 | 0.0% |
| Q3 2021 | 26 | $456.8M | 26,080,764 | 25 | 0 | 0 | 0.0% |