SPYRE THERAPEUTICS INC (SYRE)
Institutional ownership reported to the SEC as of Q2 2026, across 25 quarters.
256
Reporting holders
$8.4B
Reported value
106.0%
Of shares outstanding
0.7%
Held as options
+65
Holder change
Institutions report 93,439,369 shares against 88,173,762 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $1.2B | 13,026,187 | 0.05% | 11q | +10.6%+$110.5M |
| BlackRock, Inc. | $577.7M | 6,506,605 | 0.01% | 8q | +17.8%+$87.5M |
| PERCEPTIVE ADVISORS LLC | $383.5M | 4,319,496 | 5.76% | 12q | +14.2%+$47.6M |
| RTW INVESTMENTS, LP | $377.5M | 4,251,996 | 3.22% | 11q | +1.9%+$7.1M |
| Paradigm Biocapital Advisors LP | $341.0M | 3,840,778 | 6.38% | 8q | +96.2%+$167.2M |
| VANGUARD CAPITAL MANAGEMENT LLC | $306.2M | 3,448,681 | 0.01% | 2q | +12.8%+$34.7M |
| STATE STREET CORP | $271.4M | 3,057,416 | 0.01% | 10q | +17.3%+$40.0M |
| Venrock Adviser, LLC | $265.0M | 2,985,448 | 8.04% | 11q | -19.0%-$62.1M |
| Driehaus Capital Management LLC | $248.5M | 2,799,166 | 1.44% | 12q | HELD |
| GEODE CAPITAL MANAGEMENT, LLC | $239.3M | 2,562,265 | 0.01% | 12q | +48.9%+$78.6M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $206.9M | 2,330,098 | 0.01% | 2q | +298.2%+$154.9M |
| Capital World Investors | $205.6M | 2,315,553 | 0.02% | 7q | +247.4%+$146.4M |
| Jupiter Topco LLC | $195.9M | 2,206,936 | 0.08% | new | FIRST |
| TCG Crossover Management, LLC | $168.7M | 1,900,582 | 4.06% | 4q | HELD |
| TANG CAPITAL MANAGEMENT LLC | $168.0M | 1,892,200 | 7.63% | 6q | HELD |
| BANK OF AMERICA CORP /DE/ | $157.8M | 1,777,854 | 0.01% | 10q | +44.8%+$48.8M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $152.9M | 1,722,300 | 0.21% | new | NEW |
| WELLINGTON MANAGEMENT GROUP LLP | $140.4M | 1,581,505 | 0.02% | 12q | -13.3%-$21.6M |
| GOLDMAN SACHS GROUP INC | $131.2M | 1,478,059 | 0.01% | 10q | +447.6%+$107.3M |
| FRANKLIN RESOURCES INC | $130.8M | 1,472,943 | 0.03% | 11q | +66.8%+$52.4M |
| Remedium Capital Partners, LLC | $130.0M | 1,464,169 | 28.78% | 3q | +0.5%+$704.7K |
| Affinity Asset Advisors, LLC | $113.6M | 1,279,134 | 5.13% | 12q | HELD |
| JPMORGAN CHASE & CO | $98.9M | 1,093,026 | 0.01% | 12q | +11.6%+$10.3M |
| Holocene Advisors, LP | $90.1M | 1,015,170 | 0.20% | new | NEW |
| MARSHALL WACE, LLP | $88.0M | 991,693 | 0.07% | 2q | +612.1%+$75.7M |
| Polar Capital Holdings Plc | $87.7M | 988,009 | 0.21% | 12q | +24.6%+$17.3M |
| Siren, L.L.C. | $86.0M | 968,598 | 1.74% | 7q | +18.3%+$13.3M |
| Capital International Investors | $84.8M | 955,196 | 0.02% | 6q | -45.3%-$70.2M |
| BRAIDWELL LP | $78.1M | 879,467 | 2.89% | 11q | -5.7%-$4.7M |
| Commodore Capital LP | $75.2M | 846,786 | 4.48% | 12q | -55.7%-$94.6M |
| UBS Group AG | $74.8M | 843,071 | 0.01% | 11q | +25.6%+$15.3M |
| NORTHERN TRUST CORP | $59.9M | 674,529 | 0.01% | 10q | +16.5%+$8.5M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $58.0M | 652,958 | 0.01% | 10q | +16.0%+$8.0M |
| Sixth Street Partners Management Company, L.P. | $58.0M | 652,958 | 0.01% | new | NEW |
| Pictet Asset Management Holding SA | $55.8M | 628,138 | 0.05% | 9q | +27.8%+$12.1M |
| EMERALD ADVISERS, LLC | $50.4M | 567,430 | 1.19% | 8q | -7.5%-$4.1M |
| VICTORY CAPITAL MANAGEMENT INC | $49.2M | 553,980 | 0.03% | 7q | +89.6%+$23.2M |
| VANGUARD FIDUCIARY TRUST CO | $49.0M | 551,389 | 0.01% | 2q | +18.7%+$7.7M |
| Candriam S.C.A. | $48.5M | 546,312 | 0.22% | 10q | -10.5%-$5.7M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $46.3M | 522,071 | 0.01% | 9q | +151.8%+$27.9M |
| MORGAN STANLEY | $44.4M | 499,963 | 0.00% | 12q | +102.6%+$22.5M |
| VOYA INVESTMENT MANAGEMENT LLC | $38.3M | 431,694 | 0.03% | 3q | +699.9%+$33.5M |
| EMERALD MUTUAL FUND ADVISERS TRUST | $35.6M | 401,271 | 1.25% | 8q | -1.7%-$607.4K |
| SAMLYN CAPITAL, LLC | $35.5M | 400,075 | 0.58% | 2q | +0.9%+$303.1K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $34.2M | 39,311 | 0.00% | 3q | +35.7%+$9.0M |
| AMERIPRISE FINANCIAL INC | $31.6M | 356,082 | 0.01% | 3q | +11.8%+$3.3M |
| Integral Health Asset Management, LLC | $28.9M | 325,000 | 1.14% | new | NEW |
| Woodline Partners LP | $27.2M | 306,049 | 0.08% | 10q | +15.1%+$3.6M |
| JENNISON ASSOCIATES LLC | $26.9M | 303,180 | 0.02% | new | NEW |
| ADAR1 Capital Management, LLC | $25.2M | 283,982 | 1.15% | 6q | -16.1%-$4.8M |
| BNP PARIBAS FINANCIAL MARKETS | $23.1M | 259,923 | 0.01% | 7q | +1295.2%+$21.4M |
| Bank of New York Mellon Corp | $21.8M | 245,193 | 0.00% | 10q | +28.1%+$4.8M |
| Caption Management, LLC | $20.8M | 36,000 | 0.10% | 5q | HELD |
| Bellevue Group AG | $20.4M | 229,931 | 0.43% | new | NEW |
| Cormorant Asset Management, LP | $20.0M | 225,000 | 1.02% | new | NEW |
| SEVEN GRAND MANAGERS, LLC | $20.0M | 225,000 | 0.80% | 3q | +125.0%+$11.1M |
| EVENTIDE ASSET MANAGEMENT, LLC | $17.9M | 201,616 | 0.24% | new | NEW |
| MILLENNIUM MANAGEMENT LLC | $17.5M | 196,712 | 0.01% | 4q | +34.1%+$4.4M |
| ORBIMED ADVISORS LLC | $16.5M | 186,145 | 0.31% | new | NEW |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $16.2M | 182,931 | 0.15% | new | NEW |
| Nuveen, LLC | $16.1M | 181,105 | 0.00% | 6q | +17.7%+$2.4M |
| NEUBERGER BERMAN GROUP LLC | $16.1M | 180,884 | 0.01% | new | NEW |
| DEUTSCHE BANK AG\ | $15.5M | 174,459 | 0.00% | 10q | +35.0%+$4.0M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $15.4M | 172,923 | 0.02% | 7q | +1.5%+$225.7K |
| CITADEL ADVISORS LLC | $13.7M | 103,100 | 0.00% | 3q | -4.7%-$671.2K |
| Balyasny Asset Management L.P. | $13.1M | 147,042 | 0.02% | 3q | +165.1%+$8.1M |
| Soleus Capital Management, L.P. | $13.1M | 147,000 | 0.45% | new | NEW |
| MERCER GLOBAL ADVISORS INC /ADV | $12.6M | 142,290 | 0.01% | 5q | +100.2%+$6.3M |
| Squarepoint Ops LLC | $12.4M | 139,605 | 0.01% | new | NEW |
| ARMISTICE CAPITAL, LLC | $12.2M | 137,588 | 0.15% | 9q | +13.8%+$1.5M |
| Russell Investments Group, Ltd. | $12.0M | 134,757 | 0.01% | 5q | +1256.9%+$11.1M |
| Ensign Peak Advisors, Inc | $11.2M | 126,620 | 0.02% | 2q | -57.4%-$15.1M |
| Invesco Ltd. | $10.7M | 120,541 | 0.00% | 10q | -9.0%-$1.1M |
| Blackstone Inc. | $10.7M | 120,177 | 0.03% | 11q | -59.0%-$15.3M |
| Rhenman & Partners Asset Management AB | $10.6M | 119,300 | 1.00% | new | NEW |
| TD Asset Management Inc | $10.3M | 115,990 | 0.01% | 10q | -15.6%-$1.9M |
| Swiss National Bank | $10.0M | 112,500 | 0.01% | 10q | +16.6%+$1.4M |
| STEMPOINT CAPITAL LP | $9.5M | 106,926 | 1.64% | 3q | -68.1%-$20.3M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $9.3M | 104,516 | 0.01% | 10q | -7.4%-$739.1K |
| Boxer Capital Management, LLC | $8.9M | 100,000 | 0.67% | new | NEW |
| RHUMBLINE ADVISERS | $8.4M | 94,763 | 0.01% | 9q | +11.3%+$856.0K |
| BARCLAYS PLC | $8.4M | 94,069 | 0.00% | 11q | +105.5%+$4.3M |
| F/m Investments LLC | $8.2M | 92,618 | 0.42% | 7q | -6.9%-$607.4K |
| PRUDENTIAL FINANCIAL INC | $7.8M | 87,370 | 0.01% | 2q | +46.7%+$2.5M |
| FEDERATED HERMES, INC. | $7.6M | 85,950 | 0.01% | new | NEW |
| Granahan Investment Management, LLC | $7.4M | 82,991 | 0.26% | new | NEW |
| CITIGROUP INC | $7.3M | 82,593 | 0.00% | 11q | +587.9%+$6.3M |
| WELLS FARGO & COMPANY/MN | $7.3M | 82,506 | 0.00% | 12q | +24.2%+$1.4M |
| HighVista Strategies LLC | $6.9M | 77,807 | 1.57% | 11q | -46.8%-$6.1M |
| B Group, Inc. | $6.2M | 70,000 | 2.92% | 7q | -30.0%-$2.7M |
| Trexquant Investment LP | $5.9M | 67,007 | 0.04% | new | NEW |
| JANE STREET GROUP, LLC | $5.8M | 2,909 | 0.00% | new | NEW |
| Informed Momentum Co LLC | $5.4M | 60,393 | 0.48% | new | NEW |
| SILVERARC CAPITAL MANAGEMENT, LLC | $5.3M | 59,959 | 0.55% | 3q | -67.9%-$11.2M |
| PRINCIPAL FINANCIAL GROUP INC | $5.3M | 59,747 | 0.00% | 2q | +1289.8%+$4.9M |
| Hudson Bay Capital Management LP | $5.2M | 58,387 | 0.01% | new | NEW |
| Atle Fund Management AB | $5.1M | 57,030 | 1.36% | 2q | -9.1%-$506.5K |
| RAYMOND JAMES FINANCIAL INC | $4.8M | 53,627 | 0.00% | 2q | +171.5%+$3.0M |
| Susquehanna Portfolio Strategies, LLC | $4.7M | 53,101 | 0.08% | 4q | HELD |
| ALLIANCEBERNSTEIN L.P. | $4.7M | 92,540 | 0.00% | 9q | +30.5%+$1.1M |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | Perceptive Advisors LLCwith 2 co-filers | 4.9% |
| 2026-08-14 | 13G/A | RTW Investments, LPwith 1 co-filers | 4.8% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 256 | $8.4B | 93,439,369 | 90 | 98 | 53 | 0.7% |
| Q1 2026 | 191 | $4.1B | 81,513,313 | 50 | 63 | 44 | 0.4% |
| Q4 2025 | 145 | $2.6B | 77,862,985 | 29 | 70 | 26 | 0.7% |
| Q3 2025 | 131 | $1.1B | 63,949,965 | 22 | 39 | 40 | 0.2% |
| Q2 2025 | 121 | $938.7M | 62,588,589 | 18 | 54 | 26 | 0.2% |
| Q1 2025 | 121 | $1.0B | 61,801,934 | 19 | 49 | 29 | 0.2% |
| Q4 2024 | 121 | $1.4B | 59,304,492 | 22 | 57 | 19 | 0.0% |
| Q3 2024 | 109 | $1.5B | 50,928,323 | 24 | 39 | 23 | 0.0% |
| Q2 2024 | 101 | $1.2B | 50,654,915 | 23 | 46 | 15 | 0.0% |
| Q1 2024 | 96 | $1.2B | 31,488,303 | 48 | 19 | 14 | 0.0% |
| Q4 2023 | 52 | $599.4M | 27,935,074 | 27 | 15 | 2 | 0.0% |
| Q3 2023 | 26 | $39.5M | 3,222,866 | 26 | 0 | 0 | 0.1% |
| Q2 2023 | 2 | $136 | 0 | 1 | 0 | 0 | 100.0% |
| Q1 2023 | 1 | $145 | 0 | 0 | 0 | 0 | 100.0% |
| Q4 2022 | 1 | $225 | 0 | 1 | 0 | 0 | 100.0% |
| Q2 2022 | 1 | $1.0K | 0 | 0 | 0 | 0 | 100.0% |
| Q1 2022 | 2 | $3.0K | 0 | 0 | 0 | 0 | 100.0% |
| Q4 2021 | 2 | $41.0K | 0 | 1 | 0 | 0 | 100.0% |
| Q3 2021 | 1 | $9.0K | 0 | 0 | 0 | 0 | 100.0% |
| Q2 2021 | 2 | $148.0K | 0 | 0 | 0 | 0 | 100.0% |
| Q1 2021 | 2 | $124.0K | 0 | 2 | 0 | 0 | 100.0% |
| Q4 2020 | 1 | $2.0K | 0 | 0 | 0 | 0 | 100.0% |
| Q3 2020 | 1 | $1.0K | 0 | 1 | 0 | 0 | 100.0% |
| Q3 2019 | 2 | $20.0K | 0 | 1 | 0 | 0 | 100.0% |
| Q2 2019 | 1 | $1.0K | 0 | 1 | 0 | 0 | 100.0% |