SPERO THERAPEUTICS INC (SPRO)
Institutional ownership reported to the SEC as of Q2 2026, across 31 quarters.
60
Reporting holders
$47.6M
Reported value
36.4%
Of shares outstanding
1.5%
Held as options
+11
Holder change
Institutions report 21,195,497 shares against 58,234,827 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| GSK plc | $20.3M | 9,190,606 | 3.37% | 3q | HELD |
| Pfizer Inc | $5.3M | 2,362,348 | 3.13% | 7q | HELD |
| VANGUARD CAPITAL MANAGEMENT LLC | $4.5M | 2,036,226 | 0.00% | 2q | +13.1%+$522.3K |
| RENAISSANCE TECHNOLOGIES LLC | $2.1M | 947,904 | 0.00% | 18q | -20.3%-$533.3K |
| Alphabet Inc. | $2.0M | 889,979 | 0.00% | 35q | HELD |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1.8M | 759,290 | 0.00% | 5q | +127.9%+$1.0M |
| BlackRock, Inc. | $1.3M | 594,404 | 0.00% | 8q | +37.2%+$356.3K |
| GEODE CAPITAL MANAGEMENT, LLC | $1.3M | 566,329 | 0.00% | 31q | +8.9%+$102.6K |
| RAYMOND JAMES FINANCIAL INC | $1.2M | 521,705 | 0.00% | new | NEW |
| TWO SIGMA INVESTMENTS, LP | $846.0K | 382,814 | 0.00% | 4q | -56.8%-$1.1M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $735.9K | 332,970 | 0.00% | new | NEW |
| VANGUARD FIDUCIARY TRUST CO | $635.7K | 287,648 | 0.00% | 2q | +8.9%+$52.0K |
| DIMENSIONAL FUND ADVISORS LP | $607.6K | 274,820 | 0.00% | 4q | +823.2%+$541.8K |
| GOLDMAN SACHS GROUP INC | $567.9K | 256,985 | 0.00% | new | NEW |
| JANE STREET GROUP, LLC | $512.7K | 158,097 | 0.00% | 4q | +48.7%+$167.8K |
| STATE STREET CORP | $474.6K | 214,751 | 0.00% | 31q | HELD |
| UBS Group AG | $308.7K | 139,680 | 0.00% | 29q | +4542.1%+$302.0K |
| SIMPLEX TRADING, LLC | $298.4K | 61,312 | 0.00% | 8q | +102.3%+$150.9K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $253.7K | 114,800 | 0.00% | 14q | HELD |
| NORTHERN TRUST CORP | $239.3K | 108,274 | 0.00% | 31q | -10.5%-$28.1K |
| Point72 Asset Management, L.P. | $230.7K | 104,377 | 0.00% | 3q | +74.9%+$98.8K |
| Ionic Capital Management LLC | $227.0K | 102,698 | 0.03% | 5q | -47.6%-$206.1K |
| Federation des caisses Desjardins du Quebec | $202.2K | 91,900 | 0.00% | new | NEW |
| Shay Capital LLC | $160.0K | 72,391 | 0.01% | 4q | +2.9%+$4.5K |
| GROUP ONE TRADING LLC | $159.5K | 10,869 | 0.00% | 5q | HELD |
| CITADEL ADVISORS LLC | $145.0K | options only | 0.00% | 9q | OPTIONS |
| Invesco Ltd. | $142.0K | 64,245 | 0.00% | 5q | +41.6%+$41.7K |
| Verdad Advisers, LP | $113.5K | 51,335 | 0.11% | 2q | +53.4%+$39.5K |
| XTX Topco Ltd | $111.7K | 50,536 | 0.00% | new | NEW |
| Assenagon Asset Management S.A. | $82.4K | 37,272 | 0.00% | 4q | +100.0%+$41.2K |
| AMERICAN CENTURY COMPANIES INC | $81.4K | 36,811 | 0.00% | new | NEW |
| Capital Asset Advisory Services LLC | $71.9K | 32,548 | 0.00% | 5q | HELD |
| AXXCESS WEALTH MANAGEMENT, LLC | $71.9K | 32,548 | 0.00% | new | NEW |
| Three Seasons Wealth, LLC | $66.3K | 30,000 | 0.01% | 11q | HELD |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $63.1K | 28,565 | 0.00% | 15q | HELD |
| Sixth Street Partners Management Company, L.P. | $63.1K | 28,565 | 0.00% | new | NEW |
| Vanguard Global Advisers, LLC | $56.2K | 25,446 | 0.00% | 2q | HELD |
| Global Retirement Partners, LLC | $55.2K | 25,000 | 0.00% | new | NEW |
| OPPENHEIMER & CO INC | $50.5K | 22,850 | 0.00% | new | NEW |
| MILLENNIUM MANAGEMENT LLC | $42.6K | 19,298 | 0.00% | new | NEW |
| DLK Investment Management, LLC | $40.8K | 31,355 | 0.02% | new | NEW |
| Susquehanna Portfolio Strategies, LLC | $39.0K | 17,628 | 0.00% | new | NEW |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $35.6K | 16,095 | 0.00% | new | NEW |
| Qube Research & Technologies Ltd | $30.2K | 13,644 | 0.00% | new | NEW |
| TWO SIGMA SECURITIES, LLC | $23.4K | 10,576 | 0.00% | new | NEW |
| PRUDENTIAL FINANCIAL INC | $23.0K | 10,400 | 0.00% | new | NEW |
| CITIGROUP INC | $21.3K | 9,625 | 0.00% | 3q | -49.7%-$21.0K |
| JONES FINANCIAL COMPANIES LLLP | $17.4K | 7,678 | 0.00% | 3q | HELD |
| Integrated Wealth Concepts LLC | $13.3K | 6,000 | 0.00% | new | NEW |
| ROYAL BANK OF CANADA | $4.0K | 2,014 | 0.00% | new | NEW |
| MORGAN STANLEY | $2.0K | 914 | 0.00% | 35q | -79.9%-$8.0K |
| FMR LLC | $663 | 300 | 0.00% | new | NEW |
| OSAIC HOLDINGS, INC. | $640 | 290 | 0.00% | 5q | HELD |
| GSA CAPITAL PARTNERS LLP | $632 | 285,906 | 0.04% | 4q | +2.7% |
| JPMORGAN CHASE & CO | $533 | 236 | 0.00% | 13q | HELD |
| WELLS FARGO & COMPANY/MN | $442 | 200 | 0.00% | 15q | -50.0% |
| Rialto Wealth Management, LLC | $381 | 172 | 0.00% | new | NEW |
| US BANCORP \DE\ | $334 | 151 | 0.00% | 15q | HELD |
| SBI Securities Co., Ltd. | $29 | 13 | 0.00% | 7q | +44.4% |
| SG Americas Securities, LLC | $25 | 11,268 | 0.00% | new | NEW |
| Farther Finance Advisors, LLC | $22 | 10 | 0.00% | 3q | HELD |
| FNY Investment Advisers, LLC | $18 | 8,300 | 0.01% | 4q | +56.6% |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | $0 | 0 | 0.00% | new | NEW |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 60 | $47.6M | 21,195,497 | 23 | 15 | 8 | 1.5% |
| Q1 2026 | 49 | $49.2M | 20,781,793 | 5 | 13 | 9 | 1.1% |
| Q4 2025 | 55 | $49.4M | 20,935,168 | 13 | 12 | 11 | 1.2% |
| Q3 2025 | 47 | $21.5M | 11,191,926 | 11 | 13 | 7 | 2.2% |
| Q2 2025 | 43 | $32.9M | 10,941,232 | 19 | 8 | 7 | 3.7% |
| Q1 2025 | 37 | $10.3M | 14,231,706 | 2 | 7 | 9 | 0.1% |
| Q4 2024 | 46 | $15.4M | 14,949,333 | 6 | 11 | 7 | 0.0% |
| Q3 2024 | 44 | $15.1M | 11,271,209 | 4 | 5 | 10 | 0.0% |
| Q2 2024 | 49 | $16.7M | 12,805,355 | 4 | 11 | 8 | 0.1% |
| Q1 2024 | 52 | $20.9M | 12,108,241 | 10 | 10 | 13 | 0.2% |
| Q4 2023 | 46 | $18.4M | 12,486,649 | 4 | 8 | 9 | 0.2% |
| Q3 2023 | 50 | $16.2M | 13,348,235 | 3 | 9 | 13 | 0.4% |
| Q2 2023 | 53 | $19.9M | 13,571,676 | 10 | 9 | 14 | 1.0% |
| Q1 2023 | 45 | $24.3M | 16,689,456 | 4 | 13 | 5 | 0.6% |
| Q4 2022 | 49 | $22.3M | 12,629,900 | 13 | 4 | 15 | 2.0% |
| Q3 2022 | 63 | $40.9M | 19,853,082 | 17 | 9 | 18 | 2.8% |
| Q2 2022 | 66 | $15.6M | 20,955,995 | 14 | 20 | 18 | 0.4% |
| Q1 2022 | 99 | $176.3M | 20,241,810 | 23 | 15 | 21 | 0.1% |
| Q4 2021 | 87 | $320.8M | 19,896,025 | 2 | 24 | 19 | 0.8% |
| Q3 2021 | 90 | $341.5M | 18,370,621 | 7 | 22 | 26 | 0.9% |
| Q2 2021 | 88 | $246.1M | 17,484,841 | 14 | 27 | 20 | 0.8% |
| Q1 2021 | 93 | $275.6M | 18,553,130 | 12 | 26 | 26 | 0.9% |
| Q4 2020 | 91 | $376.4M | 19,166,914 | 26 | 33 | 22 | 1.3% |
| Q3 2020 | 79 | $187.9M | 16,774,272 | 13 | 29 | 23 | 0.4% |
| Q2 2020 | 79 | $159.4M | 11,777,132 | 28 | 34 | 12 | 0.0% |
| Q1 2020 | 60 | $93.2M | 11,533,852 | 6 | 30 | 16 | 0.0% |
| Q4 2019 | 61 | $105.1M | 10,935,889 | 8 | 28 | 10 | 0.0% |
| Q3 2019 | 59 | $110.0M | 10,375,026 | 6 | 27 | 12 | 0.0% |
| Q2 2019 | 60 | $122.4M | 10,642,327 | 9 | 25 | 10 | 0.0% |
| Q1 2019 | 55 | $118.7M | 9,268,459 | 12 | 14 | 17 | 0.0% |
| Q4 2018 | 51 | $56.6M | 9,191,169 | 3 | 1 | 1 | 0.0% |