HolderBook

SPRUCE BIOSCIENCES INC (SPRB)

Institutional ownership reported to the SEC as of Q2 2026, across 23 quarters.

64
Reporting holders
$110.0M
Reported value
70.9%
Of shares outstanding
0.0%
Held as options
+32
Holder change

Institutions report 2,037,640 shares against 2,874,013 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.

Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.

Holders

FilerValueShares Their book Held Change
AIGH Capital Management LLC$13.5M250,0000.85%newNEW
ORBIMED ADVISORS LLC$10.8M200,0000.20%newNEW
BlackRock, Inc.$10.1M187,8360.00%3q+1009.0%+$9.2M
MILLENNIUM MANAGEMENT LLC$8.7M160,9810.00%2q+43.9%+$2.7M
Ikarian Capital, LLC$6.6M121,3560.71%4qHELD
VANGUARD CAPITAL MANAGEMENT LLC$6.4M119,3310.00%2q+550.8%+$5.5M
Alyeska Investment Group, L.P.$4.4M81,6710.01%3q+58.1%+$1.6M
GEODE CAPITAL MANAGEMENT, LLC$3.8M70,5480.00%3q+447.4%+$3.1M
ADAR1 Capital Management, LLC$3.7M67,7170.17%3q+15.6%+$492.3K
Cable Car Capital, LP$3.2M60,0000.07%newNEW
Stonepine Capital Management, LLC$3.1M57,5900.80%newNEW
CITADEL ADVISORS LLC$2.8M51,9050.00%3q-25.8%-$977.1K
STATE STREET CORP$2.7M50,4500.00%3q+834.3%+$2.4M
BOOTHBAY FUND MANAGEMENT, LLC$2.3M42,0800.03%3qHELD
STEMPOINT CAPITAL LP$2.2M41,3880.38%2q+225.4%+$1.5M
Eversept Partners, LP$2.2M40,0000.11%newNEW
Carlyle Group Inc.$2.1M38,6200.02%4qHELD
GOLDMAN SACHS GROUP INC$1.7M32,3480.00%2q+487.5%+$1.4M
Affinity Asset Advisors, LLC$1.6M30,0000.07%newNEW
DIADEMA PARTNERS LP$1.6M30,0000.20%2q+200.0%+$1.1M
Point72 Asset Management, L.P.$1.5M28,2780.00%newNEW
Quinn Opportunity Partners LLC$1.4M26,8100.07%3qHELD
UBS Group AG$1.3M23,3810.00%4q+496.6%+$1.1M
ExodusPoint Capital Management, LP$1.2M22,0000.01%3qHELD
NORTHERN TRUST CORP$1.1M21,0830.00%newNEW
Rosalind Advisors, Inc.$1.1M20,0000.40%newNEW
Knott David M Jr$1.1M20,0000.57%newNEW
AMERIPRISE FINANCIAL INC$1.0M18,8340.00%newNEW
VANGUARD PORTFOLIO MANAGEMENT LLC$998.8K18,4960.00%newNEW
VANGUARD FIDUCIARY TRUST CO$991.5K18,3610.00%2q+233.0%+$693.7K
Balyasny Asset Management L.P.$655.5K12,1380.00%3q-69.7%-$1.5M
DIMENSIONAL FUND ADVISORS LP$476.6K8,8130.00%newNEW
Persistent Asset Partners Ltd$414.6K7,6770.12%2q+203.7%+$278.0K
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM$387.8K7,1820.00%newNEW
Bank of New York Mellon Corp$366.1K6,7790.00%newNEW
CHARLES SCHWAB INVESTMENT MANAGEMENT INC$318.4K5,8960.00%newNEW
Sixth Street Partners Management Company, L.P.$318.4K5,8960.00%newNEW
RENAISSANCE TECHNOLOGIES LLC$253.8K4,7000.00%newNEW
MORGAN STANLEY$238.2K4,4110.00%4q+211.7%+$161.8K
Pale Fire Capital SE$206.2K3,8180.01%newNEW
RHUMBLINE ADVISERS$190.0K3,5190.00%newNEW
DEUTSCHE BANK AG\$143.2K2,6520.00%newNEW
WELLS FARGO & COMPANY/MN$125.8K2,3290.00%newNEW
NEW YORK STATE COMMON RETIREMENT FUND$102.6K1,9000.00%newNEW
CITIGROUP INC$68.3K1,2650.00%2q+34.7%+$17.6K
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.$67.6K1,2520.00%newNEW
JPMORGAN CHASE & CO$63.0K1,1270.00%newNEW
Lion Point Capital, LP$54.0K1,0000.26%4qHELD
Police & Firemen's Retirement System of New Jersey$46.7K8640.00%newNEW
BARCLAYS PLC$36.4K6740.00%newNEW
BNP PARIBAS FINANCIAL MARKETS$24.5K4530.00%newNEW
Vanguard Global Advisers, LLC$24.4K4520.00%2qHELD
FMR LLC$18.5K3430.00%newNEW
Legal & General Group Plc$14.2K2640.00%newNEW
Ameritas Investment Partners, Inc.$13.3K2470.00%newNEW
Tower Research Capital LLC (TRC)$13.3K2460.00%3q+75.7%+$5.7K
Russell Investments Group, Ltd.$11.7K2170.00%newNEW
SBI Securities Co., Ltd.$10.9K2010.00%newNEW
ROYAL BANK OF CANADA$8.0K1660.00%newNEW
Sterling Capital Management LLC$2.3K430.00%newNEW
JONES FINANCIAL COMPANIES LLLP$1.7K300.00%3q-84.5%-$9.0K
CALDWELL SUTTER CAPITAL, INC.$702130.00%4qHELD
Friedenthal Financial$37870.00%newNEW
Cassaday & Co Wealth Management LLC$10820.00%2qHELD

Five percent filings

Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →

FiledFormFiler % of class
2026-08-1413GOrbiMed Advisors LLCwith 1 co-filers4.8%
2026-08-1413G/AKenneth Griffinwith 6 co-filers1.9%
2026-08-1413G/AADAR1 Capital Management, LLCwith 1 co-filers2.5%
2026-08-1413GAWM Investment Company, Inc.5.1%
2026-08-0413G/AIntegrated Core Strategies (US) LLCwith 3 co-filers5.8%
2026-07-3013GBlackRock, Inc.6.8%
2026-07-2713GOrin Hirschmanwith 1 co-filers9.1%

Quarter by quarter

Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.

QuarterHoldersValue SharesNewAdded TrimmedOptions
Q2 202664$110.0M2,037,640361630.0%
Q1 202632$48.8M746,1257660.0%
Q4 202531$65.3M750,85523410.0%
Q3 202510$25.1M2,937,89510000.0%
Q2 20253$72.6K2,046,8280000.0%
Q1 202529$2.7M9,366,3464560.0%
Q4 202428$4.2M10,091,1953580.2%
Q3 202431$5.8M12,354,67125100.1%
Q2 202437$7.7M14,833,82855140.6%
Q1 202447$13.5M17,118,82320980.6%
Q4 202339$93.9M32,073,450210100.0%
Q3 202340$71.5M31,679,22721090.0%
Q2 202338$68.2M31,726,262410110.0%
Q1 202339$72.8M32,958,65115890.0%
Q4 202224$18.7M17,085,6632360.0%
Q3 202233$24.7M18,047,3954490.0%
Q2 202232$28.5M16,378,02355130.0%
Q1 202243$34.4M17,091,62138170.0%
Q4 202150$79.1M17,738,830171080.0%
Q3 202143$118.1M19,639,842513150.0%
Q2 202141$225.3M20,096,188516120.0%
Q1 202140$313.2M18,868,062112120.0%
Q4 202045$458.9M18,878,62044000.0%