SEPTERNA INC (SEPN)
Institutional ownership reported to the SEC as of Q2 2026, across 7 quarters.
153
Reporting holders
$1.6B
Reported value
101.8%
Of shares outstanding
2.9%
Held as options
+30
Holder change
Institutions report 47,498,919 shares against 46,676,947 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $234.3M | 6,995,858 | 2.04% | 7q | HELD |
| TRV GP V, LLC | $208.2M | 6,215,591 | 41.78% | 7q | HELD |
| Driehaus Capital Management LLC | $148.5M | 4,433,058 | 0.86% | 7q | +0.9%+$1.3M |
| TRV GP VI, LLC | $141.0M | 4,211,659 | 60.72% | 7q | HELD |
| SAMSARA BIOCAPITAL, LLC | $105.5M | 3,149,128 | 8.66% | 7q | HELD |
| GOLDMAN SACHS GROUP INC | $102.6M | 3,062,766 | 0.01% | 7q | +5.4%+$5.2M |
| BlackRock, Inc. | $64.7M | 1,932,088 | 0.00% | 7q | +6.0%+$3.7M |
| Siren, L.L.C. | $63.6M | 1,900,000 | 1.29% | 7q | -5.0%-$3.3M |
| Avoro Capital Advisors LLC | $44.8M | 1,337,500 | 0.40% | 7q | HELD |
| Jupiter Topco LLC | $43.7M | 1,307,500 | 0.02% | new | FIRST |
| VANGUARD CAPITAL MANAGEMENT LLC | $40.9M | 1,221,673 | 0.00% | 2q | +2.1%+$827.6K |
| PRIMECAP MANAGEMENT CO/CA/ | $39.1M | 1,167,382 | 0.02% | 3q | +11.3%+$4.0M |
| First Light Asset Management, LLC | $32.3M | 963,260 | 1.96% | 3q | +31.4%+$7.7M |
| ADAR1 Capital Management, LLC | $31.5M | 940,747 | 1.44% | 6q | -13.7%-$5.0M |
| GEODE CAPITAL MANAGEMENT, LLC | $22.8M | 679,163 | 0.00% | 7q | +5.3%+$1.1M |
| Caption Management, LLC | $22.7M | 38,006 | 0.11% | new | NEW |
| STATE STREET CORP | $21.9M | 652,630 | 0.00% | 7q | +3.4%+$709.4K |
| LOOMIS SAYLES & CO L P | $20.9M | 624,752 | 0.03% | new | NEW |
| Casdin Capital, LLC | $18.5M | 553,268 | 0.93% | 7q | HELD |
| Catalio Capital Management, LP | $18.0M | 536,152 | 3.37% | 7q | +82.1%+$8.1M |
| ALGERT GLOBAL LLC | $13.3M | 397,487 | 0.16% | 3q | +844.8%+$11.9M |
| Kalehua Capital Management LLC | $13.0M | 389,088 | 4.16% | 3q | HELD |
| Balyasny Asset Management L.P. | $11.7M | 350,442 | 0.01% | 3q | +48.1%+$3.8M |
| TUDOR INVESTMENT CORP ET AL | $11.0M | 28,966 | 0.02% | new | NEW |
| Longaeva Partners L.P. | $10.0M | 298,171 | 0.22% | 4q | +299.9%+$7.5M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9.9M | options only | 0.00% | 6q | OPTIONS |
| Soleus Capital Management, L.P. | $9.2M | 275,000 | 0.32% | 7q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $7.7M | 230,184 | 0.00% | 2q | +18.0%+$1.2M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $7.5M | 222,702 | 0.01% | 7q | -0.6%-$43.3K |
| TWO SIGMA INVESTMENTS, LP | $7.4M | 220,885 | 0.01% | 6q | +193.1%+$4.9M |
| NORTHERN TRUST CORP | $6.7M | 201,131 | 0.00% | 7q | +22.2%+$1.2M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $6.3M | 187,041 | 0.00% | 7q | +3.0%+$182.9K |
| Sixth Street Partners Management Company, L.P. | $6.3M | 187,041 | 0.00% | new | NEW |
| Woodline Partners LP | $6.2M | 185,535 | 0.02% | new | NEW |
| VANGUARD FIDUCIARY TRUST CO | $5.5M | 165,656 | 0.00% | 2q | +7.2%+$374.2K |
| MORGAN STANLEY | $4.5M | 134,377 | 0.00% | 7q | +21.6%+$798.6K |
| JANE STREET GROUP, LLC | $3.4M | 45,552 | 0.00% | new | NEW |
| UBS Group AG | $3.0M | 89,874 | 0.00% | 7q | -23.2%-$907.7K |
| JPMORGAN CHASE & CO | $3.0M | 85,301 | 0.00% | 7q | +0.7%+$21.8K |
| CITADEL ADVISORS LLC | $3.0M | 6,350 | 0.00% | new | NEW |
| FEDERATED HERMES, INC. | $2.9M | 86,753 | 0.00% | 3q | -2.9%-$85.3K |
| LAZARD ASSET MANAGEMENT LLC | $2.5M | 75,425 | 0.00% | new | NEW |
| DIMENSIONAL FUND ADVISORS LP | $2.5M | 75,309 | 0.00% | new | NEW |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2.5M | 74,649 | 0.00% | new | NEW |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $2.3M | 68,180 | 0.01% | 4q | +139.8%+$1.3M |
| HUSSMAN STRATEGIC ADVISORS, INC. | $2.1M | 63,000 | 0.49% | 2q | -40.0%-$1.4M |
| AMERICAN CENTURY COMPANIES INC | $2.0M | 60,973 | 0.00% | 4q | -0.5%-$10.6K |
| DIADEMA PARTNERS LP | $2.0M | options only | 0.25% | 2q | OPTIONS |
| Bank of New York Mellon Corp | $1.9M | 56,176 | 0.00% | 7q | -4.3%-$84.8K |
| XTX Topco Ltd | $1.8M | 54,489 | 0.02% | 3q | +48.4%+$595.0K |
| MILLENNIUM MANAGEMENT LLC | $1.7M | 50,562 | 0.00% | 6q | -59.3%-$2.5M |
| BARCLAYS PLC | $1.7M | 49,821 | 0.00% | 7q | +119.3%+$907.8K |
| Elmind Capital, LP | $1.7M | 49,444 | 0.42% | new | NEW |
| Nuveen, LLC | $1.6M | 48,229 | 0.00% | 6q | +65.3%+$638.1K |
| Sofinnova Investments, Inc. | $1.6M | 47,506 | 0.08% | 2q | HELD |
| D. E. Shaw & Co., Inc. | $1.6M | 46,483 | 0.00% | new | NEW |
| Voleon Capital Management LP | $1.5M | 44,435 | 0.03% | new | NEW |
| RENAISSANCE TECHNOLOGIES LLC | $1.4M | 41,419 | 0.00% | 2q | +9.9%+$124.5K |
| Russell Investments Group, Ltd. | $1.3M | 40,209 | 0.00% | 4q | +249.2%+$961.0K |
| BANK OF AMERICA CORP /DE/ | $1.2M | 35,875 | 0.00% | 7q | +38.1%+$331.6K |
| Alyeska Investment Group, L.P. | $1.2M | 35,000 | 0.00% | 7q | HELD |
| Brevan Howard Capital Management LP | $986.3K | 29,452 | 0.01% | new | NEW |
| HighVista Strategies LLC | $982.5K | 29,337 | 0.22% | new | NEW |
| RHUMBLINE ADVISERS | $925.5K | 27,636 | 0.00% | 7q | +3.9%+$34.6K |
| Trexquant Investment LP | $858.9K | 25,645 | 0.01% | 3q | -27.4%-$323.4K |
| Invesco Ltd. | $806.9K | 24,094 | 0.00% | 7q | -70.9%-$2.0M |
| Logos Global Management LP | $788.6K | 23,548 | 0.03% | 7q | HELD |
| FMR LLC | $778.3K | 23,240 | 0.00% | 7q | -0.9%-$6.9K |
| FOX RUN MANAGEMENT, L.L.C. | $738.1K | 22,038 | 0.12% | new | NEW |
| DEUTSCHE BANK AG\ | $732.5K | 21,873 | 0.00% | 7q | +29.9%+$168.5K |
| ALLIANCEBERNSTEIN L.P. | $718.5K | 29,900 | 0.00% | 5q | +52.6%+$247.5K |
| Squarepoint Ops LLC | $710.6K | 21,219 | 0.00% | 3q | +17.3%+$105.0K |
| STRS OHIO | $703.3K | 21,000 | 0.00% | 3q | +22.1%+$127.3K |
| FRED ALGER MANAGEMENT, LLC | $701.9K | 20,958 | 0.00% | new | NEW |
| Jump Financial, LLC | $676.5K | 20,200 | 0.01% | 3q | -61.9%-$1.1M |
| Swiss National Bank | $663.1K | 19,800 | 0.00% | 2q | -10.4%-$77.0K |
| WELLS FARGO & COMPANY/MN | $659.2K | 19,684 | 0.00% | 7q | HELD |
| FRANKLIN RESOURCES INC | $623.1K | 18,607 | 0.00% | new | NEW |
| CITIGROUP INC | $596.4K | 17,808 | 0.00% | 7q | +93.7%+$288.4K |
| Aquatic Capital Management LLC | $583.6K | 17,427 | 0.02% | new | NEW |
| Engineers Gate Manager LP | $581.1K | 17,350 | 0.01% | 2q | +5.0%+$27.5K |
| BNP PARIBAS FINANCIAL MARKETS | $567.5K | 16,946 | 0.00% | 7q | +216.1%+$388.0K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $555.8K | 16,597 | 0.00% | 3q | +16.8%+$79.8K |
| State of Wyoming | $548.5K | 16,379 | 0.06% | new | NEW |
| Vanguard Global Advisers, LLC | $544.1K | 16,247 | 0.00% | 2q | HELD |
| AQR CAPITAL MANAGEMENT LLC | $515.6K | 15,397 | 0.00% | 3q | HELD |
| Verdad Advisers, LP | $434.4K | 12,970 | 0.42% | new | NEW |
| MetLife Investment Management, LLC | $431.4K | 12,880 | 0.00% | 5q | -5.9%-$27.0K |
| OSAIC HOLDINGS, INC. | $421.8K | 12,594 | 0.00% | 5q | -0.8%-$3.5K |
| Man Group plc | $384.1K | 11,469 | 0.00% | 2q | -3.3%-$13.0K |
| China Universal Asset Management Co., Ltd. | $360.8K | 10,774 | 0.02% | 3q | -9.8%-$39.3K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $341.4K | 10,193 | 0.00% | 7q | +1.7%+$5.8K |
| Legal & General Group Plc | $337.0K | 10,062 | 0.00% | 7q | +75.4%+$144.9K |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $334.3K | 9,982 | 0.00% | 2q | -3.9%-$13.4K |
| Gotham Asset Management, LLC | $312.2K | 9,322 | 0.00% | new | NEW |
| Virtus Investment Advisers, LLC | $304.8K | 9,102 | 0.07% | 3q | -15.1%-$54.2K |
| CANADA PENSION PLAN INVESTMENT BOARD | $298.1K | 8,900 | 0.00% | new | NEW |
| NEW YORK STATE COMMON RETIREMENT FUND | $284.7K | 8,500 | 0.00% | 7q | +51.8%+$97.1K |
| FIRST TRUST ADVISORS LP | $259.2K | 7,739 | 0.00% | new | NEW |
| Creative Planning | $255.7K | 7,636 | 0.00% | new | NEW |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | DRIEHAUS CAPITAL MANAGEMENT LLC | 9.8% |
| 2026-08-14 | 13D/A | RA Capital Management, L.P.with 3 co-filers | 11.8% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 153 | $1.6B | 47,498,919 | 47 | 45 | 32 | 2.9% |
| Q1 2026 | 123 | $1.1B | 45,888,137 | 22 | 40 | 30 | 0.2% |
| Q4 2025 | 118 | $1.3B | 45,563,004 | 37 | 28 | 25 | 0.6% |
| Q3 2025 | 82 | $852.2M | 44,525,207 | 10 | 28 | 18 | 1.7% |
| Q2 2025 | 85 | $480.8M | 44,356,530 | 27 | 26 | 19 | 2.5% |
| Q1 2025 | 67 | $262.5M | 45,229,667 | 15 | 24 | 13 | 0.2% |
| Q4 2024 | 68 | $998.5M | 43,602,071 | 64 | 0 | 0 | 0.0% |