PROTAGONIST THERAPEUTICS INC (PTGX)
Institutional ownership reported to the SEC as of Q2 2026, across 31 quarters.
324
Reporting holders
$9.1B
Reported value
113.5%
Of shares outstanding
0.9%
Held as options
+19
Holder change
Institutions report 73,452,136 shares against 64,708,285 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| BlackRock, Inc. | $1.3B | 10,307,837 | 0.02% | 8q | +5.4%+$64.8M |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | $778.2M | 6,348,906 | 3.59% | 31q | HELD |
| RTW INVESTMENTS, LP | $620.4M | 5,061,175 | 5.30% | 28q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $444.9M | 3,629,298 | 0.02% | 2q | +4.3%+$18.2M |
| WELLINGTON MANAGEMENT GROUP LLP | $418.8M | 3,416,781 | 0.07% | 8q | -5.1%-$22.4M |
| UBS Group AG | $416.7M | 3,399,221 | 0.05% | 31q | -34.4%-$218.0M |
| STATE STREET CORP | $407.2M | 3,321,554 | 0.01% | 31q | +6.6%+$25.1M |
| VANGUARD CAPITAL MANAGEMENT LLC | $349.8M | 2,853,394 | 0.01% | 2q | +1.7%+$5.8M |
| JOHNSON & JOHNSON | $300.2M | 2,449,183 | 37.59% | 20q | HELD |
| Invesco Ltd. | $286.9M | 2,340,667 | 0.02% | 22q | +8.1%+$21.6M |
| Jupiter Topco LLC | $261.0M | 2,129,780 | 0.11% | new | FIRST |
| GEODE CAPITAL MANAGEMENT, LLC | $213.5M | 1,741,209 | 0.01% | 31q | +4.3%+$8.8M |
| Woodline Partners LP | $173.3M | 1,414,173 | 0.54% | 10q | HELD |
| BANK OF AMERICA CORP /DE/ | $162.4M | 1,324,498 | 0.01% | 31q | +2.2%+$3.6M |
| JENNISON ASSOCIATES LLC | $141.2M | 1,151,681 | 0.08% | 3q | +7.4%+$9.8M |
| PERCEPTIVE ADVISORS LLC | $120.4M | 981,879 | 1.81% | 14q | -20.2%-$30.5M |
| ADAR1 Capital Management, LLC | $117.8M | 960,863 | 5.39% | 11q | -3.3%-$4.1M |
| MORGAN STANLEY | $111.1M | 905,992 | 0.01% | 35q | -11.0%-$13.8M |
| Alyeska Investment Group, L.P. | $109.0M | 889,298 | 0.28% | 3q | +49.9%+$36.3M |
| Hood River Capital Management LLC | $108.2M | 882,738 | 0.78% | 2q | +6.4%+$6.6M |
| GOLDMAN SACHS GROUP INC | $99.6M | 812,852 | 0.01% | 31q | +4.4%+$4.2M |
| Driehaus Capital Management LLC | $89.6M | 731,053 | 0.52% | 11q | +1.4%+$1.2M |
| Clearbridge Investments, LLC | $88.9M | 725,335 | 0.07% | 3q | +16.6%+$12.7M |
| FMR LLC | $82.4M | 672,186 | 0.00% | 31q | +1.5%+$1.2M |
| NORTHERN TRUST CORP | $81.7M | 666,105 | 0.01% | 31q | +13.3%+$9.6M |
| AMERICAN CENTURY COMPANIES INC | $73.4M | 598,600 | 0.03% | 11q | +11.4%+$7.5M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $71.6M | 583,774 | 0.01% | 29q | +5.6%+$3.8M |
| Sixth Street Partners Management Company, L.P. | $71.6M | 583,774 | 0.01% | new | NEW |
| VOYA INVESTMENT MANAGEMENT LLC | $70.1M | 571,618 | 0.06% | 24q | +25.8%+$14.4M |
| Pictet Asset Management Holding SA | $69.6M | 567,990 | 0.07% | 9q | -2.3%-$1.6M |
| FRANKLIN RESOURCES INC | $63.7M | 520,032 | 0.01% | 10q | +277.2%+$46.8M |
| VANGUARD FIDUCIARY TRUST CO | $53.7M | 437,747 | 0.01% | 2q | +6.1%+$3.1M |
| Public Sector Pension Investment Board | $50.9M | 415,376 | 0.07% | 8q | +97.5%+$25.1M |
| PRINCIPAL FINANCIAL GROUP INC | $47.2M | 385,262 | 0.02% | 16q | +4.7%+$2.1M |
| Bank of New York Mellon Corp | $43.9M | 358,300 | 0.01% | 31q | +4.9%+$2.1M |
| Caption Management, LLC | $43.7M | 45,000 | 0.20% | 8q | HELD |
| NEUBERGER BERMAN GROUP LLC | $37.1M | 302,427 | 0.02% | 5q | +113.8%+$19.7M |
| BNP PARIBAS FINANCIAL MARKETS | $37.0M | 301,472 | 0.01% | 31q | +55.0%+$13.1M |
| 683 Capital Management, LLC | $35.5M | 290,000 | 1.75% | 15q | -18.3%-$8.0M |
| Nuveen, LLC | $34.8M | 284,085 | 0.01% | 6q | +122.1%+$19.1M |
| Stephens Investment Management Group LLC | $34.5M | 281,832 | 0.37% | new | NEW |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $31.9M | 259,972 | 0.03% | 8q | -15.1%-$5.6M |
| Eagle Health Investments LP | $30.4M | 248,322 | 5.05% | 3q | +38.5%+$8.5M |
| NEXTBio Capital Management LP | $26.9M | 219,333 | 12.37% | 3q | -4.5%-$1.3M |
| SEGALL BRYANT & HAMILL, LLC | $26.3M | 214,724 | 0.31% | 5q | +0.9%+$246.4K |
| SEB Asset Management AB | $25.7M | 209,963 | 0.10% | 2q | -9.7%-$2.8M |
| CITIGROUP INC | $24.4M | 198,668 | 0.01% | 30q | +25.2%+$4.9M |
| ORBIMED ADVISORS LLC | $23.5M | 42,100 | 0.44% | 3q | HELD |
| JPMORGAN CHASE & CO | $22.6M | 183,098 | 0.00% | 31q | +5.8%+$1.2M |
| DIMENSIONAL FUND ADVISORS LP | $21.8M | 178,152 | 0.00% | 31q | -64.9%-$40.4M |
| Affinity Asset Advisors, LLC | $21.1M | 172,125 | 0.95% | 7q | HELD |
| Fisher Asset Management, LLC | $20.9M | 170,524 | 0.01% | 3q | -2.0%-$422.5K |
| Boxer Capital Management, LLC | $20.8M | 170,000 | 1.57% | 5q | HELD |
| RAYMOND JAMES FINANCIAL INC | $20.6M | 168,270 | 0.01% | 7q | -5.1%-$1.1M |
| NAN FUNG TRINITY (HK) LTD | $19.7M | 160,670 | 1.94% | 5q | HELD |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $19.4M | 57,062 | 0.00% | 24q | -65.9%-$37.5M |
| AMERIPRISE FINANCIAL INC | $17.6M | 143,810 | 0.00% | 8q | -50.6%-$18.1M |
| DEUTSCHE BANK AG\ | $17.4M | 141,838 | 0.01% | 34q | +13.1%+$2.0M |
| RHUMBLINE ADVISERS | $17.3M | 141,279 | 0.01% | 29q | -10.2%-$2.0M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $17.3M | 141,081 | 0.03% | new | NEW |
| TD Asset Management Inc | $16.5M | 134,950 | 0.01% | 14q | -26.5%-$6.0M |
| KENNEDY CAPITAL MANAGEMENT LLC | $16.4M | 134,019 | 0.29% | 22q | -2.2%-$377.5K |
| Legal & General Group Plc | $16.2M | 132,351 | 0.00% | 29q | -2.2%-$369.7K |
| Russell Investments Group, Ltd. | $14.1M | 115,425 | 0.01% | 10q | +185.9%+$9.2M |
| MARSHALL WACE, LLP | $13.4M | 109,017 | 0.01% | 4q | -82.6%-$63.6M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $13.3M | 108,555 | 0.01% | 29q | -15.1%-$2.4M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $13.1M | 107,094 | 0.00% | 14q | HELD |
| Catalio Capital Management, LP | $13.1M | 106,799 | 2.46% | new | NEW |
| Swiss National Bank | $12.6M | 102,400 | 0.01% | 23q | +3.5%+$429.0K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $12.5M | 102,002 | 0.02% | 6q | -3.3%-$430.5K |
| Opaleye Management Inc. | $12.3M | 100,000 | 1.11% | 11q | HELD |
| ASSETMARK, INC | $12.1M | 98,687 | 0.02% | 8q | +112.5%+$6.4M |
| SEI INVESTMENTS CO | $11.4M | 92,749 | 0.01% | 22q | +11.5%+$1.2M |
| ALGERT GLOBAL LLC | $10.8M | 87,698 | 0.13% | 3q | -44.1%-$8.5M |
| PRUDENTIAL FINANCIAL INC | $10.4M | 85,180 | 0.01% | 8q | -10.6%-$1.2M |
| VICTORY CAPITAL MANAGEMENT INC | $10.3M | 83,883 | 0.01% | 10q | HELD |
| AXIOM INVESTORS LLC /DE | $10.0M | 81,683 | 0.09% | 6q | -4.4%-$464.8K |
| WELLS FARGO & COMPANY/MN | $8.8M | 71,944 | 0.00% | 31q | +19.6%+$1.4M |
| ALLIANCEBERNSTEIN L.P. | $8.4M | 79,563 | 0.00% | 28q | +7.8%+$608.5K |
| NORDEA INVESTMENT MANAGEMENT AB | $7.9M | 64,964 | 0.01% | 2q | +25.4%+$1.6M |
| Knott David M Jr | $7.7M | 63,000 | 4.08% | 12q | HELD |
| Atika Capital Management LLC | $7.6M | 62,100 | 0.50% | 4q | HELD |
| Moody Aldrich Partners LLC | $7.3M | 59,601 | 1.31% | 13q | +10.6%+$699.7K |
| Eversept Partners, LP | $7.2M | 58,504 | 0.37% | new | NEW |
| GREAT LAKES ADVISORS, LLC | $7.0M | 56,904 | 0.05% | 14q | -19.9%-$1.7M |
| Creative Planning | $6.9M | 56,185 | 0.00% | 8q | +17.1%+$1.0M |
| Bellevue Group AG | $6.8M | 55,682 | 0.14% | 12q | +285.4%+$5.1M |
| FIRST TRUST ADVISORS LP | $6.7M | 54,865 | 0.00% | 10q | -37.6%-$4.0M |
| KVP Capital Advisors, LP | $6.5M | 53,000 | 4.77% | 3q | HELD |
| VANGUARD ASSET MANAGEMENT, Ltd | $6.3M | 51,639 | 0.00% | 2q | +11.3%+$643.9K |
| CASTLEARK MANAGEMENT LLC | $6.2M | 50,570 | 0.17% | new | NEW |
| Granahan Investment Management, LLC | $6.1M | 49,809 | 0.22% | 2q | +81.8%+$2.7M |
| Louisiana State Employees Retirement System | $6.0M | 52,600 | 0.05% | 8q | +101.5%+$3.0M |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | $6.0M | 48,894 | 0.00% | 9q | HELD |
| EXCHANGE TRADED CONCEPTS, LLC | $5.9M | 48,248 | 0.01% | 8q | +103.0%+$3.0M |
| CITADEL ADVISORS LLC | $5.6M | options only | 0.00% | 23q | OPTIONS |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $5.6M | 45,668 | 0.04% | 21q | -4.7%-$277.4K |
| Seven Fleet Capital Management LP | $5.6M | 45,400 | 0.92% | 3q | +1035.0%+$5.1M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $5.5M | 44,529 | 0.00% | new | NEW |
| EFG International AG | $5.0M | 40,501 | 0.09% | 3q | -19.1%-$1.2M |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-13 | 13G/A | Farallon Capital Management, L.L.C.with 28 co-filers | 10.0% |
| 2026-08-07 | 13G | STATE STREET CORPORATION | 5.2% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 324 | $9.1B | 73,452,136 | 59 | 121 | 76 | 0.9% |
| Q1 2026 | 305 | $8.1B | 76,742,698 | 50 | 102 | 90 | 0.6% |
| Q4 2025 | 298 | $6.1B | 68,481,772 | 69 | 87 | 96 | 1.5% |
| Q3 2025 | 253 | $4.6B | 68,779,230 | 34 | 74 | 97 | 0.3% |
| Q2 2025 | 255 | $3.9B | 69,365,569 | 47 | 109 | 69 | 1.0% |
| Q1 2025 | 255 | $3.1B | 62,990,283 | 66 | 76 | 82 | 2.6% |
| Q4 2024 | 217 | $2.4B | 61,948,566 | 34 | 79 | 69 | 0.7% |
| Q3 2024 | 217 | $2.7B | 60,568,364 | 68 | 66 | 58 | 0.3% |
| Q2 2024 | 176 | $2.0B | 58,248,785 | 29 | 56 | 61 | 0.4% |
| Q1 2024 | 166 | $1.8B | 62,979,077 | 44 | 54 | 46 | 0.4% |
| Q4 2023 | 141 | $1.3B | 57,920,087 | 22 | 37 | 52 | 1.2% |
| Q3 2023 | 128 | $936.1M | 55,399,689 | 16 | 58 | 36 | 1.4% |
| Q2 2023 | 151 | $1.6B | 54,576,888 | 38 | 53 | 45 | 4.6% |
| Q1 2023 | 119 | $1.2B | 48,061,563 | 35 | 38 | 36 | 4.6% |
| Q4 2022 | 108 | $438.9M | 40,544,799 | 19 | 40 | 31 | 2.8% |
| Q3 2022 | 132 | $406.7M | 47,310,168 | 28 | 38 | 40 | 1.9% |
| Q2 2022 | 134 | $445.8M | 53,361,425 | 28 | 43 | 39 | 5.3% |
| Q1 2022 | 143 | $1.3B | 50,634,019 | 19 | 53 | 46 | 5.4% |
| Q4 2021 | 153 | $1.8B | 49,862,351 | 32 | 58 | 33 | 4.7% |
| Q3 2021 | 133 | $861.7M | 46,402,692 | 28 | 57 | 33 | 4.8% |
| Q2 2021 | 139 | $2.2B | 48,157,484 | 27 | 58 | 35 | 0.2% |
| Q1 2021 | 129 | $1.1B | 44,334,581 | 24 | 41 | 41 | 0.2% |
| Q4 2020 | 128 | $877.8M | 43,410,059 | 40 | 48 | 20 | 0.3% |
| Q3 2020 | 93 | $728.1M | 37,284,812 | 22 | 29 | 31 | 0.0% |
| Q2 2020 | 85 | $605.4M | 34,256,558 | 26 | 41 | 14 | 0.0% |
| Q1 2020 | 76 | $165.1M | 23,376,646 | 6 | 24 | 27 | 0.0% |
| Q4 2019 | 80 | $165.4M | 23,466,508 | 16 | 34 | 14 | 0.0% |
| Q3 2019 | 74 | $227.5M | 18,937,553 | 17 | 29 | 18 | 0.0% |
| Q2 2019 | 66 | $208.5M | 17,221,539 | 15 | 30 | 16 | 0.0% |
| Q1 2019 | 64 | $189.3M | 15,062,271 | 11 | 23 | 23 | 0.0% |
| Q4 2018 | 65 | $94.0M | 13,975,159 | 2 | 0 | 3 | 0.0% |