PRELUDE THERAPEUTICS INC (PRLD)
Institutional ownership reported to the SEC as of Q2 2026, across 24 quarters.
77
Reporting holders
$263.2M
Reported value
61.4%
Of shares outstanding
0.7%
Held as options
+23
Holder change
Institutions report 49,020,245 shares against 79,803,485 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | $73.2M | 13,724,571 | 1.36% | 24q | +25.8%+$15.0M |
| BAKER BROS. ADVISORS LP | $54.0M | 10,123,824 | 0.27% | 24q | HELD |
| RA CAPITAL MANAGEMENT, L.P. | $34.5M | 6,475,882 | 0.30% | new | NEW |
| Soleus Capital Management, L.P. | $18.0M | 3,378,378 | 0.62% | new | NEW |
| Kynam Capital Management, LP | $12.9M | 2,415,087 | 0.71% | 3q | +51.6%+$4.4M |
| VANGUARD CAPITAL MANAGEMENT LLC | $10.7M | 2,009,445 | 0.00% | 2q | +63.3%+$4.2M |
| BlackRock, Inc. | $9.6M | 1,797,501 | 0.00% | 8q | +458.4%+$7.9M |
| SPHERA FUNDS MANAGEMENT LTD. | $5.4M | 1,019,832 | 0.71% | 3q | +82.7%+$2.5M |
| TWO SIGMA INVESTMENTS, LP | $5.3M | 993,369 | 0.00% | 19q | +7.6%+$371.7K |
| ADAR1 Capital Management, LLC | $4.8M | 900,900 | 0.22% | 2q | +489.5%+$4.0M |
| MILLENNIUM MANAGEMENT LLC | $4.5M | 844,993 | 0.00% | 8q | +120.8%+$2.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $4.5M | 841,862 | 0.00% | 23q | +178.3%+$2.9M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $4.1M | 766,095 | 0.01% | new | NEW |
| MORGAN STANLEY | $2.7M | 503,860 | 0.00% | 24q | +56.4%+$968.5K |
| STATE STREET CORP | $2.3M | 428,787 | 0.00% | 23q | +210.2%+$1.5M |
| UBS Group AG | $1.7M | 318,797 | 0.00% | 15q | +394.2%+$1.4M |
| VANGUARD FIDUCIARY TRUST CO | $1.5M | 284,886 | 0.00% | 2q | +81.0%+$679.6K |
| RENAISSANCE TECHNOLOGIES LLC | $1.5M | 281,200 | 0.00% | 19q | +2.2%+$32.0K |
| NORTHERN TRUST CORP | $1.3M | 240,599 | 0.00% | 23q | +380.0%+$1.0M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1.0M | 193,920 | 0.00% | new | NEW |
| MARSHALL WACE, LLP | $1.0M | 190,692 | 0.00% | 3q | -46.9%-$896.6K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $931.2K | options only | 0.00% | 3q | OPTIONS |
| Connor, Clark & Lunn Investment Management Ltd. | $669.5K | 125,606 | 0.00% | 3q | +15.1%+$88.1K |
| GOLDMAN SACHS GROUP INC | $644.0K | 120,834 | 0.00% | 22q | -48.9%-$616.3K |
| JANE STREET GROUP, LLC | $448.8K | options only | 0.00% | 5q | OPTIONS |
| Hillsdale Investment Management Inc. | $433.9K | 81,400 | 0.01% | new | NEW |
| CITADEL ADVISORS LLC | $372.9K | 22,554 | 0.00% | 2q | -81.9%-$1.7M |
| Bank of New York Mellon Corp | $363.4K | 68,187 | 0.00% | new | NEW |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $360.4K | 67,622 | 0.00% | new | NEW |
| Sixth Street Partners Management Company, L.P. | $360.4K | 67,622 | 0.00% | new | NEW |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $343.8K | 64,500 | 0.01% | 17q | +20.6%+$58.6K |
| Squarepoint Ops LLC | $317.3K | 59,540 | 0.00% | new | NEW |
| SIMPLEX TRADING, LLC | $264.4K | options only | 0.00% | 3q | OPTIONS |
| PANAGORA ASSET MANAGEMENT INC | $253.6K | 47,574 | 0.00% | new | NEW |
| Mariner, LLC | $241.2K | 45,261 | 0.00% | new | NEW |
| Nuveen, LLC | $197.3K | 37,023 | 0.00% | new | NEW |
| DIMENSIONAL FUND ADVISORS LP | $186.8K | 35,210 | 0.00% | 2q | HELD |
| Invesco Ltd. | $185.2K | 34,742 | 0.00% | new | NEW |
| Cerity Partners LLC | $175.2K | 32,875 | 0.00% | 8q | HELD |
| State of Wyoming | $175.2K | 32,862 | 0.02% | new | NEW |
| Graham Capital Management, L.P. | $158.7K | 29,770 | 0.00% | 2q | +162.5%+$98.2K |
| DEUTSCHE BANK AG\ | $148.3K | 27,824 | 0.00% | new | NEW |
| WELLS FARGO & COMPANY/MN | $135.0K | 25,325 | 0.00% | new | NEW |
| BANK OF AMERICA CORP /DE/ | $127.3K | 23,875 | 0.00% | 23q | -57.8%-$174.0K |
| RHUMBLINE ADVISERS | $117.6K | 22,074 | 0.00% | new | NEW |
| Vanguard Global Advisers, LLC | $86.4K | 16,210 | 0.00% | 2q | +249.7%+$61.7K |
| ExodusPoint Capital Management, LP | $82.5K | 15,475 | 0.00% | new | NEW |
| BARCLAYS PLC | $77.4K | 14,529 | 0.00% | 18q | +68.9%+$31.6K |
| NEW YORK STATE COMMON RETIREMENT FUND | $75.7K | 14,200 | 0.00% | new | NEW |
| HSBC HOLDINGS PLC | $74.4K | 13,652 | 0.00% | 12q | HELD |
| MANGROVE PARTNERS IM, LLC | $71.2K | 13,352 | 0.00% | new | NEW |
| Qube Research & Technologies Ltd | $69.9K | 13,110 | 0.00% | 3q | -20.1%-$17.6K |
| CITIGROUP INC | $69.5K | 13,033 | 0.00% | 23q | +260560.0%+$69.4K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $68.1K | 12,784 | 0.00% | new | NEW |
| JPMORGAN CHASE & CO | $66.7K | 13,538 | 0.00% | 23q | +21735.5%+$66.4K |
| Spark Investment Management LLC | $56.5K | 10,600 | 0.11% | new | NEW |
| Police & Firemen's Retirement System of New Jersey | $55.9K | 10,492 | 0.00% | new | NEW |
| GROUP ONE TRADING LLC | $41.6K | 3,907 | 0.00% | 8q | HELD |
| ALLIANCEBERNSTEIN L.P. | $36.0K | 10,530 | 0.00% | new | NEW |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $34.3K | 6,430 | 0.00% | new | NEW |
| FMR LLC | $30.0K | 5,629 | 0.00% | 24q | -6.3%-$2.0K |
| STRS OHIO | $29.3K | 5,500 | 0.00% | new | NEW |
| BNP PARIBAS FINANCIAL MARKETS | $21.9K | 4,104 | 0.00% | 7q | +4220.0%+$21.4K |
| Legal & General Group Plc | $14.4K | 2,699 | 0.00% | new | NEW |
| ROYAL BANK OF CANADA | $14.0K | 2,658 | 0.00% | 23q | +16.4%+$2.0K |
| Ameritas Investment Partners, Inc. | $13.4K | 2,520 | 0.00% | new | NEW |
| Tower Research Capital LLC (TRC) | $12.7K | 2,377 | 0.00% | new | NEW |
| Russell Investments Group, Ltd. | $11.8K | 2,220 | 0.00% | new | NEW |
| NISA INVESTMENT ADVISORS, LLC | $8.7K | 1,634 | 0.00% | 7q | HELD |
| PNC Financial Services Group, Inc. | $6.2K | 1,171 | 0.00% | 9q | HELD |
| Quarry LP | $4.0K | 755 | 0.00% | new | NEW |
| ACADIAN ASSET MANAGEMENT LLC | $3.3K | 611,359 | 0.00% | 12q | +19.5% |
| Fortitude Family Office, LLC | $1.2K | 230 | 0.00% | 2q | HELD |
| Sterling Capital Management LLC | $517 | 97 | 0.00% | new | NEW |
| PRICE T ROWE ASSOCIATES INC /MD/ | $122 | 22,758 | 0.00% | new | NEW |
| SBI Securities Co., Ltd. | $117 | 22 | 0.00% | 7q | -99.2%-$13.9K |
| Caitong International Asset Management Co., Ltd | $96 | 18 | 0.00% | new | NEW |
| GSA CAPITAL PARTNERS LLP | $68 | 12,672 | 0.00% | new | NEW |
| MERCER GLOBAL ADVISORS INC /ADV | $27 | 5 | 0.00% | new | NEW |
| Optiver Holding B.V. | $21 | 4 | 0.00% | 4q | -80.0% |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-07-08 | 13G | Soleus Capital Management, L.P.with 8 co-filers | 5.2% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 77 | $263.2M | 49,020,245 | 34 | 24 | 10 | 0.7% |
| Q1 2026 | 54 | $103.4M | 30,202,150 | 10 | 20 | 9 | 0.1% |
| Q4 2025 | 46 | $79.0M | 27,193,573 | 12 | 14 | 11 | 0.1% |
| Q3 2025 | 41 | $36.9M | 25,655,547 | 3 | 7 | 20 | 0.0% |
| Q2 2025 | 46 | $20.8M | 25,647,258 | 6 | 11 | 21 | 0.0% |
| Q1 2025 | 52 | $22.1M | 28,778,500 | 3 | 15 | 21 | 0.1% |
| Q4 2024 | 57 | $39.1M | 30,634,372 | 5 | 22 | 11 | 0.0% |
| Q3 2024 | 63 | $69.1M | 33,376,036 | 13 | 17 | 19 | 0.0% |
| Q2 2024 | 58 | $125.8M | 33,009,613 | 9 | 13 | 20 | 0.0% |
| Q1 2024 | 53 | $159.3M | 33,601,577 | 6 | 14 | 18 | 0.0% |
| Q4 2023 | 50 | $144.0M | 33,731,196 | 5 | 25 | 10 | 0.0% |
| Q3 2023 | 52 | $109.2M | 35,329,407 | 5 | 23 | 13 | 0.0% |
| Q2 2023 | 48 | $158.9M | 34,713,219 | 14 | 19 | 9 | 0.0% |
| Q1 2023 | 43 | $197.8M | 34,697,946 | 5 | 14 | 11 | 0.0% |
| Q4 2022 | 46 | $183.9M | 30,459,532 | 10 | 9 | 15 | 0.0% |
| Q3 2022 | 50 | $211.9M | 31,821,699 | 5 | 15 | 18 | 0.7% |
| Q2 2022 | 58 | $173.0M | 32,737,051 | 10 | 15 | 20 | 1.2% |
| Q1 2022 | 67 | $236.9M | 34,109,944 | 10 | 18 | 26 | 0.6% |
| Q4 2021 | 77 | $438.1M | 35,181,178 | 29 | 27 | 13 | 0.0% |
| Q3 2021 | 61 | $1.1B | 35,967,378 | 9 | 25 | 13 | 0.0% |
| Q2 2021 | 57 | $986.6M | 34,458,562 | 8 | 24 | 11 | 0.0% |
| Q1 2021 | 60 | $1.4B | 32,543,662 | 16 | 27 | 8 | 0.0% |
| Q4 2020 | 51 | $2.5B | 34,651,491 | 31 | 5 | 7 | 0.0% |
| Q3 2020 | 38 | $999.8M | 33,322,061 | 38 | 0 | 0 | 0.0% |