PRAXIS PRECISION MEDICINES I (PRAX)
Institutional ownership reported to the SEC as of Q2 2026, across 23 quarters.
303
Reporting holders
$11.4B
Reported value
117.3%
Of shares outstanding
3.9%
Held as options
+13
Holder change
Institutions report 32,755,165 shares against 27,919,988 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| Jupiter Topco LLC | $1.1B | 3,421,374 | 0.47% | new | FIRST |
| FMR LLC | $775.7M | 2,316,907 | 0.03% | 11q | +7.2%+$52.2M |
| BlackRock, Inc. | $767.5M | 2,292,585 | 0.01% | 8q | -1.4%-$10.8M |
| PERCEPTIVE ADVISORS LLC | $681.6M | 2,035,986 | 10.23% | 10q | HELD |
| BAKER BROS. ADVISORS LP | $587.0M | 1,753,198 | 2.94% | 10q | HELD |
| Orbis Allan Gray Ltd | $512.2M | 1,529,788 | 1.76% | 3q | -38.1%-$315.6M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $447.0M | 1,335,185 | 0.02% | 2q | +76.4%+$193.7M |
| VANGUARD CAPITAL MANAGEMENT LLC | $413.6M | 1,235,299 | 0.01% | 2q | +1.1%+$4.5M |
| STATE STREET CORP | $343.7M | 1,026,443 | 0.01% | 11q | +16.1%+$47.6M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $340.0M | 1,015,480 | 0.48% | 11q | +24.5%+$66.9M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $322.5M | 963,351 | 3.36% | 6q | HELD |
| Driehaus Capital Management LLC | $321.1M | 959,048 | 1.86% | 10q | +1.0%+$3.3M |
| MORGAN STANLEY | $285.9M | 854,112 | 0.02% | 11q | +2.5%+$6.9M |
| GEODE CAPITAL MANAGEMENT, LLC | $250.5M | 748,039 | 0.01% | 11q | +14.9%+$32.5M |
| Cormorant Asset Management, LP | $214.3M | 640,000 | 10.98% | 11q | -27.7%-$82.2M |
| GOLDMAN SACHS GROUP INC | $183.7M | 548,830 | 0.02% | 10q | -22.8%-$54.2M |
| BANK OF AMERICA CORP /DE/ | $183.1M | 546,930 | 0.01% | 11q | +2.3%+$4.1M |
| Invesco Ltd. | $180.0M | 537,548 | 0.01% | 10q | +775.5%+$159.4M |
| Hood River Capital Management LLC | $142.3M | 425,167 | 1.03% | 3q | +18.6%+$22.3M |
| Verition Fund Management LLC | $134.7M | options only | 0.34% | new | OPTIONS |
| NORGES BANK | $116.2M | 346,969 | 0.01% | 8q | +7869.0%+$114.7M |
| FRANKLIN RESOURCES INC | $109.5M | 327,124 | 0.02% | 10q | +18.5%+$17.1M |
| Pictet Asset Management Holding SA | $98.0M | 291,689 | 0.09% | 3q | +1.8%+$1.7M |
| Polar Capital Holdings Plc | $93.5M | 279,131 | 0.22% | new | NEW |
| Vivo Capital, LLC | $90.8M | 271,116 | 8.29% | 5q | -20.0%-$22.7M |
| Logos Global Management LP | $87.0M | 260,000 | 3.75% | 5q | -8.8%-$8.4M |
| NORTHERN TRUST CORP | $80.6M | 240,887 | 0.01% | 11q | +5.7%+$4.3M |
| AMERICAN CENTURY COMPANIES INC | $79.5M | 237,315 | 0.04% | 4q | +85.0%+$36.5M |
| ORBIMED ADVISORS LLC | $77.0M | 230,100 | 1.43% | 3q | +33.4%+$19.3M |
| Caption Management, LLC | $75.3M | options only | 0.35% | 9q | OPTIONS |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $73.7M | 220,008 | 0.01% | 10q | +2.1%+$1.5M |
| Sixth Street Partners Management Company, L.P. | $73.7M | 220,008 | 0.01% | new | NEW |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $73.3M | 218,898 | 0.24% | 2q | +32966.2%+$73.1M |
| Woodline Partners LP | $67.0M | 200,013 | 0.21% | 7q | HELD |
| Nantahala Capital Management, LLC | $67.0M | options only | 1.11% | new | OPTIONS |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $66.4M | 3,594 | 0.01% | 11q | -57.8%-$91.0M |
| BNP PARIBAS FINANCIAL MARKETS | $63.1M | 188,409 | 0.02% | 10q | +31.7%+$15.2M |
| VANGUARD FIDUCIARY TRUST CO | $63.0M | 188,161 | 0.01% | 2q | +10.7%+$6.1M |
| Affinity Asset Advisors, LLC | $61.9M | 185,000 | 2.80% | 3q | +8.8%+$5.0M |
| Soleus Capital Management, L.P. | $59.4M | 177,517 | 2.05% | 10q | -46.3%-$51.2M |
| Aberdeen Group plc | $55.7M | 166,399 | 0.08% | 3q | -3.5%-$2.0M |
| Qube Research & Technologies Ltd | $51.0M | 152,475 | 0.05% | 4q | +18.9%+$8.1M |
| MARSHALL WACE, LLP | $45.9M | 137,008 | 0.04% | 4q | +203.5%+$30.8M |
| UBS Group AG | $43.9M | 131,046 | 0.01% | 11q | +20.8%+$7.6M |
| WELLINGTON MANAGEMENT GROUP LLP | $42.1M | 125,867 | 0.01% | 10q | -27.8%-$16.2M |
| VOYA INVESTMENT MANAGEMENT LLC | $40.9M | 122,227 | 0.04% | 3q | +334.4%+$31.5M |
| 683 Capital Management, LLC | $37.0M | options only | 1.82% | 3q | OPTIONS |
| Nuveen, LLC | $36.2M | 108,032 | 0.01% | 6q | +50.0%+$12.0M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $36.0M | 107,409 | 0.01% | 3q | +1353.8%+$33.5M |
| Ikarian Capital, LLC | $31.4M | 72,842 | 3.38% | 6q | +1.8%+$543.3K |
| MetLife Investment Management, LLC | $30.3M | 90,543 | 0.14% | 9q | +11.9%+$3.2M |
| NEUBERGER BERMAN GROUP LLC | $30.0M | 89,468 | 0.02% | 3q | +244.6%+$21.3M |
| Velan Capital Investment Management LP | $29.7M | 88,781 | 18.10% | 11q | -11.9%-$4.0M |
| Bank of New York Mellon Corp | $28.6M | 85,376 | 0.00% | 9q | -1.9%-$559.4K |
| First Turn Management, LLC | $28.0M | 83,528 | 2.99% | 3q | +96.8%+$13.8M |
| ACUTA CAPITAL PARTNERS, LLC | $27.7M | 82,796 | 19.32% | 11q | -2.5%-$704.7K |
| Alyeska Investment Group, L.P. | $27.1M | 80,846 | 0.07% | 7q | +12.0%+$2.9M |
| ADAR1 Capital Management, LLC | $24.9M | 74,253 | 1.14% | 3q | +4850.2%+$24.4M |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $24.8M | 74,207 | 0.23% | 2q | +39.1%+$7.0M |
| Ensign Peak Advisors, Inc | $24.4M | 72,952 | 0.04% | 3q | -46.7%-$21.4M |
| JANE STREET GROUP, LLC | $24.1M | 1,008 | 0.00% | 11q | HELD |
| ALLIANCEBERNSTEIN L.P. | $23.0M | 71,518 | 0.01% | 9q | +158.2%+$14.1M |
| 72 Investment Holdings, LLC | $22.1M | 65,933 | 44.18% | 11q | HELD |
| SILVERARC CAPITAL MANAGEMENT, LLC | $22.0M | 65,679 | 2.29% | 11q | -8.2%-$2.0M |
| AMERIPRISE FINANCIAL INC | $21.5M | 64,295 | 0.00% | 3q | +3.0%+$621.0K |
| DEUTSCHE BANK AG\ | $21.5M | 64,263 | 0.01% | 11q | +11.2%+$2.2M |
| RAYMOND JAMES FINANCIAL INC | $20.8M | 61,980 | 0.01% | 3q | +1065.0%+$19.0M |
| Candriam S.C.A. | $20.4M | 60,856 | 0.09% | 8q | -4.4%-$927.1K |
| AQR CAPITAL MANAGEMENT LLC | $19.6M | 58,446 | 0.01% | 5q | HELD |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $19.0M | 56,840 | 0.03% | new | NEW |
| Russell Investments Group, Ltd. | $17.1M | 51,033 | 0.01% | 5q | +120.8%+$9.3M |
| Squarepoint Ops LLC | $17.1M | 42,501 | 0.02% | 3q | +2014.5%+$16.3M |
| CITADEL ADVISORS LLC | $16.9M | 7,331 | 0.00% | 11q | HELD |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $16.1M | 48,118 | 0.02% | 3q | +1.4%+$229.7K |
| JPMORGAN CHASE & CO | $15.8M | 44,085 | 0.00% | 11q | -45.0%-$12.9M |
| Boxer Capital Management, LLC | $15.6M | 46,457 | 1.17% | 3q | HELD |
| Swiss National Bank | $15.4M | 46,100 | 0.01% | 9q | -1.3%-$200.9K |
| ArrowMark Colorado Holdings LLC | $15.4M | 46,030 | 0.64% | 3q | -60.9%-$24.0M |
| California Public Employees Retirement System | $15.2M | 45,370 | 0.01% | 2q | +7.6%+$1.1M |
| KVP Capital Advisors, LP | $14.4M | 42,900 | 10.54% | 3q | HELD |
| SEB Asset Management AB | $14.3M | 42,705 | 0.05% | new | NEW |
| SEI INVESTMENTS CO | $13.4M | 40,117 | 0.01% | 3q | +35.9%+$3.5M |
| Integral Health Asset Management, LLC | $13.4M | 40,000 | 0.53% | 3q | HELD |
| EVENTIDE ASSET MANAGEMENT, LLC | $13.0M | 38,684 | 0.17% | 3q | HELD |
| PFM Health Sciences, LP | $12.9M | 38,575 | 1.11% | 11q | +8.9%+$1.1M |
| STEMPOINT CAPITAL LP | $12.5M | 37,243 | 2.15% | 3q | -66.9%-$25.2M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $12.1M | 36,187 | 0.00% | 9q | -5.1%-$655.5K |
| Burkehill Global Management, LP | $11.7M | 35,000 | 0.42% | 3q | HELD |
| University of Wisconsin Foundation | $11.6M | 34,730 | 9.21% | 2q | +37.7%+$3.2M |
| B Group, Inc. | $11.1M | 33,237 | 5.22% | 6q | HELD |
| RHUMBLINE ADVISERS | $10.8M | 32,347 | 0.01% | 11q | -1.6%-$178.1K |
| DIMENSIONAL FUND ADVISORS LP | $10.6M | 31,574 | 0.00% | 4q | +1.3%+$138.3K |
| HighVista Strategies LLC | $10.1M | 30,210 | 2.31% | 8q | +14.8%+$1.3M |
| Clearbridge Investments, LLC | $9.4M | 27,981 | 0.01% | new | NEW |
| WELLS FARGO & COMPANY/MN | $9.3M | 27,889 | 0.00% | 11q | +20.1%+$1.6M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $9.1M | 27,185 | 0.01% | 9q | -2.0%-$187.6K |
| Exome Asset Management LLC | $9.1M | 27,205 | 5.62% | 5q | -40.2%-$6.1M |
| TD Asset Management Inc | $9.1M | 27,162 | 0.01% | 10q | -22.7%-$2.7M |
| CAPITAL FUND MANAGEMENT S.A. | $9.1M | 27,058 | 0.04% | new | NEW |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $8.8M | 26,147 | 0.01% | 10q | -13.1%-$1.3M |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | ORBIS INVESTMENT MANAGEMENT LTDwith 1 co-filers | 5.5% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 303 | $11.4B | 32,755,165 | 52 | 115 | 91 | 3.9% |
| Q1 2026 | 290 | $10.3B | 31,140,435 | 78 | 114 | 68 | 2.3% |
| Q4 2025 | 244 | $8.8B | 28,506,064 | 104 | 82 | 44 | 5.2% |
| Q3 2025 | 146 | $1.3B | 23,812,906 | 30 | 55 | 43 | 3.7% |
| Q2 2025 | 138 | $992.6M | 22,684,538 | 22 | 60 | 35 | 4.0% |
| Q1 2025 | 143 | $884.0M | 22,317,513 | 31 | 45 | 49 | 4.4% |
| Q4 2024 | 154 | $1.7B | 20,484,641 | 28 | 51 | 51 | 5.9% |
| Q3 2024 | 126 | $1.1B | 17,736,575 | 25 | 41 | 42 | 3.9% |
| Q2 2024 | 115 | $797.0M | 17,493,461 | 37 | 39 | 26 | 9.2% |
| Q1 2024 | 104 | $950.9M | 15,515,296 | 58 | 28 | 15 | 0.4% |
| Q4 2023 | 56 | $182.9M | 8,199,269 | 55 | 0 | 2 | 0.1% |
| Q3 2023 | 71 | $191.5M | 111,952,461 | 13 | 18 | 19 | 0.1% |
| Q2 2023 | 73 | $131.3M | 114,167,674 | 20 | 17 | 24 | 0.0% |
| Q1 2023 | 79 | $41.5M | 51,040,311 | 16 | 32 | 16 | 0.5% |
| Q4 2022 | 83 | $97.5M | 40,995,073 | 15 | 16 | 32 | 0.0% |
| Q3 2022 | 105 | $98.3M | 43,043,532 | 23 | 28 | 28 | 0.6% |
| Q2 2022 | 96 | $106.9M | 43,113,955 | 26 | 37 | 19 | 1.3% |
| Q1 2022 | 102 | $465.4M | 45,371,542 | 13 | 36 | 25 | 0.4% |
| Q4 2021 | 98 | $864.6M | 43,841,527 | 14 | 44 | 15 | 0.1% |
| Q3 2021 | 93 | $791.9M | 42,808,840 | 21 | 36 | 16 | 0.1% |
| Q2 2021 | 82 | $751.4M | 41,166,709 | 26 | 37 | 10 | 0.0% |
| Q1 2021 | 68 | $1.2B | 36,624,673 | 11 | 23 | 13 | 0.0% |
| Q4 2020 | 69 | $2.0B | 36,202,782 | 68 | 0 | 0 | 0.0% |