| RA CAPITAL MANAGEMENT, L.P. | $791.9M | 28,933,371 | 6.88% | new | NEW |
| FMR LLC | $281.7M | 10,292,735 | 0.01% | new | NEW |
| ARCH Venture Management, LLC | $175.5M | 6,412,780 | 15.95% | new | NEW |
| venBio Partners LLC | $144.1M | 5,266,697 | 27.75% | new | NEW |
| Alphabet Inc. | $134.6M | 4,919,498 | 0.14% | new | NEW |
| Nextech Invest Ltd. | $127.6M | 4,663,176 | 6.06% | new | NEW |
| Cormorant Asset Management, LP | $126.3M | 4,615,612 | 6.47% | new | NEW |
| REGENERON PHARMACEUTICALS, INC. | $114.0M | 4,166,666 | 64.35% | new | NEW |
| Siren, L.L.C. | $81.9M | 2,992,259 | 1.66% | new | NEW |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | $64.8M | 2,368,200 | 0.30% | new | NEW |
| Jupiter Topco LLC | $62.7M | 2,296,547 | 0.03% | new | FIRST |
| Frazier Life Sciences Management, L.P. | $52.6M | 1,920,805 | 1.14% | new | NEW |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $51.5M | 1,880,704 | 0.54% | new | NEW |
| General Catalyst Group Management, LLC | $43.8M | 1,600,937 | 23.24% | new | NEW |
| GENERAL ATLANTIC, L.P. | $42.1M | 1,538,461 | 1.45% | new | NEW |
| Soleus Capital Management, L.P. | $40.1M | 1,465,070 | 1.38% | new | NEW |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $35.6M | 1,302,479 | 0.00% | new | NEW |
| VANGUARD CAPITAL MANAGEMENT LLC | $31.7M | 1,156,962 | 0.00% | new | NEW |
| JPMORGAN CHASE & CO | $30.4M | 1,042,772 | 0.00% | new | NEW |
| Foresite Capital Management VI LLC | $27.3M | 999,044 | 4.26% | new | NEW |
| Catalio Capital Management, LP | $22.6M | 824,043 | 4.24% | new | NEW |
| ALLIANCEBERNSTEIN L.P. | $22.2M | 810,279 | 0.01% | new | NEW |
| Casdin Capital, LLC | $17.7M | 645,690 | 0.88% | new | NEW |
| Venrock Adviser, LLC | $17.1M | 625,000 | 0.52% | new | NEW |
| Rock Springs Capital Management LP | $15.8M | 578,028 | 0.77% | new | NEW |
| SAMSARA BIOCAPITAL, LLC | $15.2M | 556,044 | 1.25% | new | NEW |
| Logos Global Management LP | $14.4M | 525,000 | 0.62% | new | NEW |
| BAKER BROS. ADVISORS LP | $13.7M | 500,000 | 0.07% | new | NEW |
| Bellevue Group AG | $13.7M | 500,000 | 0.29% | new | NEW |
| MARSHALL WACE, LLP | $12.2M | 445,359 | 0.01% | new | NEW |
| FRANKLIN RESOURCES INC | $10.4M | 381,487 | 0.00% | new | NEW |
| ICONIQ Capital, LLC | $9.6M | 350,000 | 0.28% | new | NEW |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $8.1M | 295,962 | 0.00% | new | NEW |
| Kynam Capital Management, LP | $6.8M | 250,000 | 0.38% | new | NEW |
| FEDERATED HERMES, INC. | $6.7M | 246,200 | 0.01% | new | NEW |
| AMERIPRISE FINANCIAL INC | $4.8M | 174,773 | 0.00% | new | NEW |
| Driehaus Capital Management LLC | $2.7M | 100,000 | 0.02% | new | NEW |
| GEODE CAPITAL MANAGEMENT, LLC | $2.7M | 99,358 | 0.00% | new | NEW |
| TD Asset Management Inc | $2.1M | 76,982 | 0.00% | new | NEW |
| Squarepoint Ops LLC | $1.3M | 48,484 | 0.00% | new | NEW |
| TUDOR INVESTMENT CORP ET AL | $1.2M | 44,045 | 0.00% | new | NEW |
| UBS Group AG | $1.1M | 38,698 | 0.00% | new | NEW |
| WINTON GROUP Ltd | $955.2K | 34,900 | 0.03% | new | NEW |
| VANGUARD FIDUCIARY TRUST CO | $760.9K | 27,800 | 0.00% | new | NEW |
| Balyasny Asset Management L.P. | $664.1K | 24,264 | 0.00% | new | NEW |
| Hudson Bay Capital Management LP | $621.0K | 22,690 | 0.00% | new | NEW |
| Brevan Howard Capital Management LP | $617.6K | 22,565 | 0.00% | new | NEW |
| Ghisallo Capital Management LLC | $547.4K | 20,000 | 0.01% | new | NEW |
| Mitsubishi UFJ Asset Management Co., Ltd. | $525.5K | 19,200 | 0.00% | new | NEW |
| Vanguard Personalized Indexing Management, LLC | $321.0K | 11,729 | 0.00% | new | NEW |
| Alyeska Investment Group, L.P. | $273.7K | 10,000 | 0.00% | new | NEW |
| Burkehill Global Management, LP | $273.7K | 10,000 | 0.01% | new | NEW |
| SEVEN GRAND MANAGERS, LLC | $273.7K | 10,000 | 0.01% | new | NEW |
| ExodusPoint Capital Management, LP | $265.2K | 9,691 | 0.00% | new | NEW |
| Scientech Research LLC | $261.8K | 9,564 | 0.21% | new | NEW |
| TWO SIGMA INVESTMENTS, LP | $239.2K | 8,741 | 0.00% | new | NEW |
| GOLDMAN SACHS GROUP INC | $225.9K | 8,253 | 0.00% | new | NEW |
| Persistent Asset Partners Ltd | $113.0K | 4,130 | 0.03% | new | NEW |
| Tower Research Capital LLC (TRC) | $56.7K | 2,070 | 0.00% | new | NEW |
| CITIGROUP INC | $51.2K | 1,869 | 0.00% | new | NEW |
| China Universal Asset Management Co., Ltd. | $43.8K | 1,600 | 0.00% | new | NEW |
| WELLS FARGO & COMPANY/MN | $31.5K | 1,152 | 0.00% | new | NEW |
| OSAIC HOLDINGS, INC. | $25.2K | 920 | 0.00% | new | NEW |
| PRICE T ROWE ASSOCIATES INC /MD/ | $20.6K | 751,947 | 0.00% | new | NEW |
| Parallel Advisors, LLC | $15.1K | 550 | 0.00% | new | NEW |
| Rialto Wealth Management, LLC | $13.9K | 508 | 0.00% | new | NEW |
| Longaeva Partners L.P. | $13.7K | 500 | 0.00% | new | NEW |
| Bell Investment Advisors, Inc | $12.3K | 451 | 0.00% | new | NEW |
| EverSource Wealth Advisors, LLC | $7.1K | 261 | 0.00% | new | NEW |
| MORGAN STANLEY | $5.5K | 200 | 0.00% | new | NEW |
| Atlantic Union Bankshares Corp | $4.9K | 180 | 0.00% | new | NEW |
| JONES FINANCIAL COMPANIES LLLP | $3.0K | 103 | 0.00% | new | NEW |
| Allworth Financial LP | $2.7K | 100 | 0.00% | new | NEW |
| MERCER GLOBAL ADVISORS INC /ADV | $1.7K | 61 | 0.00% | new | NEW |
| FIFTH THIRD BANCORP | $1.6K | 60 | 0.00% | new | NEW |
| Physician Wealth Advisors, Inc. | $1.6K | 59 | 0.00% | new | NEW |
| North Star Investment Management Corp. | $1.4K | 52 | 0.00% | new | NEW |
| Cornerstone Financial Management LLC | $794 | 29 | 0.00% | new | NEW |
| Bogart Wealth, LLC | $520 | 19 | 0.00% | new | NEW |
| Avion Wealth | $1 | 69 | 0.00% | new | NEW |