MBX BIOSCIENCES INC (MBX)
Institutional ownership reported to the SEC as of Q2 2026, across 8 quarters.
171
Reporting holders
$3.1B
Reported value
113.9%
Of shares outstanding
1.1%
Held as options
+19
Holder change
Institutions report 54,854,876 shares against 48,160,096 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | $367.2M | 6,652,013 | 8.00% | 8q | HELD |
| FMR LLC | $293.8M | 5,322,885 | 0.01% | 7q | +81.3%+$131.7M |
| WELLINGTON MANAGEMENT GROUP LLP | $274.8M | 4,977,523 | 0.05% | 8q | +55.9%+$98.6M |
| NEA Management Company, LLC | $199.5M | 3,614,486 | 12.56% | 8q | HELD |
| ORBIMED ADVISORS LLC | $189.3M | 3,428,736 | 3.51% | 8q | -5.7%-$11.5M |
| BlackRock, Inc. | $183.5M | 3,323,672 | 0.00% | 7q | +13.0%+$21.1M |
| Paradigm Biocapital Advisors LP | $138.4M | 2,508,015 | 2.59% | new | NEW |
| NVP ASSOCIATES, LLC | $117.9M | 2,136,335 | 35.93% | 8q | HELD |
| Deep Track Capital, LP | $95.6M | 1,732,569 | 1.39% | 8q | -37.2%-$56.6M |
| Polar Capital Holdings Plc | $88.8M | 1,608,514 | 0.21% | 2q | -0.8%-$754.7K |
| VANGUARD CAPITAL MANAGEMENT LLC | $81.6M | 1,477,388 | 0.00% | 2q | HELD |
| Aaron Wealth Advisors LLC | $64.5M | 1,167,799 | 3.27% | 6q | HELD |
| Driehaus Capital Management LLC | $58.3M | 1,056,579 | 0.34% | 8q | +3.8%+$2.1M |
| Kynam Capital Management, LP | $51.6M | 934,799 | 2.85% | 4q | HELD |
| Woodline Partners LP | $49.7M | 900,092 | 0.15% | 8q | HELD |
| EVENTIDE ASSET MANAGEMENT, LLC | $48.2M | 873,492 | 0.64% | 3q | -1.9%-$911.2K |
| STATE STREET CORP | $47.7M | 864,466 | 0.00% | 7q | +9.8%+$4.3M |
| Parkman Healthcare Partners LLC | $44.2M | 800,173 | 4.52% | 7q | HELD |
| GEODE CAPITAL MANAGEMENT, LLC | $42.7M | 773,072 | 0.00% | 8q | +15.3%+$5.7M |
| BRAIDWELL LP | $39.2M | 710,880 | 1.45% | 3q | -52.4%-$43.1M |
| TCG Crossover Management, LLC | $35.9M | 650,000 | 0.86% | 8q | HELD |
| Cormorant Asset Management, LP | $30.4M | 550,000 | 1.56% | 8q | -50.9%-$31.5M |
| Soleus Capital Management, L.P. | $28.4M | 515,279 | 0.98% | 4q | +188.0%+$18.6M |
| GOLDMAN SACHS GROUP INC | $25.3M | 459,005 | 0.00% | 4q | HELD |
| MARSHALL WACE, LLP | $22.2M | 401,885 | 0.02% | 2q | +540.9%+$18.7M |
| Caption Management, LLC | $22.1M | options only | 0.10% | new | OPTIONS |
| EcoR1 Capital, LLC | $21.4M | 388,500 | 1.04% | 8q | -50.0%-$21.4M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $19.1M | 346,717 | 0.00% | 2q | +18.2%+$2.9M |
| BANK OF AMERICA CORP /DE/ | $16.5M | 298,927 | 0.00% | 7q | +939.7%+$14.9M |
| Rock Springs Capital Management LP | $16.5M | 298,218 | 0.80% | 4q | +3.6%+$565.9K |
| Candriam S.C.A. | $16.0M | 289,893 | 0.07% | 2q | -1.5%-$247.1K |
| UBS Group AG | $15.1M | 272,747 | 0.00% | 7q | -21.4%-$4.1M |
| Opaleye Management Inc. | $14.4M | 260,000 | 1.30% | 6q | HELD |
| FRANKLIN RESOURCES INC | $13.9M | 252,665 | 0.00% | new | NEW |
| Schonfeld Strategic Advisors LLC | $13.7M | 248,670 | 0.05% | 7q | +100.8%+$6.9M |
| MORGAN STANLEY | $13.7M | 248,558 | 0.00% | 7q | +687.5%+$12.0M |
| NORTHERN TRUST CORP | $13.6M | 246,678 | 0.00% | 7q | +17.1%+$2.0M |
| DIMENSIONAL FUND ADVISORS LP | $12.9M | 233,700 | 0.00% | 2q | +399.9%+$10.3M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $12.9M | 233,095 | 0.00% | 7q | +8.5%+$1.0M |
| Sixth Street Partners Management Company, L.P. | $12.9M | 233,095 | 0.00% | new | NEW |
| MILLENNIUM MANAGEMENT LLC | $12.5M | 226,151 | 0.00% | 8q | -59.9%-$18.7M |
| Tetragon Partners GP Ltd | $11.2M | 203,543 | 1.77% | 4q | +39.9%+$3.2M |
| VANGUARD FIDUCIARY TRUST CO | $11.1M | 201,429 | 0.00% | 2q | +18.4%+$1.7M |
| Caligan Partners LP | $11.0M | 200,000 | 0.52% | 2q | -76.4%-$35.8M |
| D. E. Shaw & Co., Inc. | $10.1M | 182,767 | 0.00% | 3q | -36.7%-$5.9M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8.4M | 26,684 | 0.00% | 6q | +181.3%+$5.4M |
| JPMORGAN CHASE & CO | $7.5M | 139,611 | 0.00% | 7q | -5.1%-$401.0K |
| KVP Capital Advisors, LP | $6.7M | 121,524 | 4.92% | 3q | HELD |
| TWO SIGMA INVESTMENTS, LP | $6.3M | 113,475 | 0.00% | 4q | -1.4%-$88.3K |
| Burkehill Global Management, LP | $5.5M | 100,000 | 0.20% | 4q | HELD |
| Nuveen, LLC | $5.5M | 98,733 | 0.00% | 6q | +20.7%+$935.1K |
| TD Asset Management Inc | $5.3M | 95,598 | 0.00% | 8q | -17.6%-$1.1M |
| Elmind Capital, LP | $5.0M | 91,000 | 1.26% | 3q | -56.9%-$6.6M |
| Bank of New York Mellon Corp | $4.9M | 88,927 | 0.00% | 7q | +10.9%+$480.5K |
| PRUDENTIAL FINANCIAL INC | $4.9M | 88,045 | 0.01% | new | NEW |
| BARCLAYS PLC | $4.8M | 87,854 | 0.00% | 8q | +642.1%+$4.2M |
| Affinity Asset Advisors, LLC | $4.1M | 75,000 | 0.19% | 4q | -50.0%-$4.1M |
| PFM Health Sciences, LP | $3.9M | 70,971 | 0.34% | 4q | -1.3%-$50.9K |
| BOOTHBAY FUND MANAGEMENT, LLC | $3.9M | 70,353 | 0.05% | 2q | -66.2%-$7.6M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3.6M | 66,112 | 0.00% | 8q | -27.1%-$1.4M |
| MOORE CAPITAL MANAGEMENT, LP | $3.6M | 64,893 | 0.05% | new | NEW |
| Rhenman & Partners Asset Management AB | $3.4M | 62,000 | 0.32% | new | NEW |
| EXCHANGE TRADED CONCEPTS, LLC | $3.0M | 54,842 | 0.01% | 2q | +60.1%+$1.1M |
| Invesco Ltd. | $2.8M | 50,678 | 0.00% | 4q | +84.1%+$1.3M |
| ALPS ADVISORS INC | $2.7M | 48,012 | 0.01% | 7q | +31.4%+$632.7K |
| PLATINUM INVESTMENT MANAGEMENT LTD | $2.4M | 43,597 | 0.59% | 8q | HELD |
| Swiss National Bank | $2.4M | 42,900 | 0.00% | 2q | -3.4%-$82.8K |
| Ensign Peak Advisors, Inc | $2.3M | 42,156 | 0.00% | new | NEW |
| ALGERT GLOBAL LLC | $2.3M | 42,070 | 0.03% | 2q | -41.6%-$1.7M |
| Creative Planning | $2.2M | 39,524 | 0.00% | 4q | +9.9%+$196.2K |
| JANE STREET GROUP, LLC | $2.1M | options only | 0.00% | 4q | OPTIONS |
| RHUMBLINE ADVISERS | $2.1M | 37,196 | 0.00% | 7q | +9.8%+$183.5K |
| DEUTSCHE BANK AG\ | $1.7M | 31,693 | 0.00% | 7q | +38.1%+$482.6K |
| WELLS FARGO & COMPANY/MN | $1.6M | 28,313 | 0.00% | 7q | +31.5%+$374.8K |
| CITADEL ADVISORS LLC | $1.4M | options only | 0.00% | 5q | OPTIONS |
| VOYA INVESTMENT MANAGEMENT LLC | $1.4M | 26,132 | 0.00% | new | NEW |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $1.4M | 25,800 | 0.00% | new | NEW |
| CITIGROUP INC | $1.4M | 25,122 | 0.00% | 7q | +86.1%+$641.6K |
| AMERICAN CENTURY COMPANIES INC | $1.3M | 22,680 | 0.00% | 3q | +159.9%+$770.3K |
| AQR CAPITAL MANAGEMENT LLC | $1.2M | 22,591 | 0.00% | 5q | -17.5%-$264.7K |
| Legal & General Group Plc | $1.2M | 21,583 | 0.00% | 8q | +11.5%+$122.8K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1.2M | 21,344 | 0.00% | 3q | +194.9%+$778.7K |
| Cerity Partners LLC | $1.2M | 20,997 | 0.00% | 3q | -0.8%-$9.2K |
| Vanguard Global Advisers, LLC | $1.0M | 18,969 | 0.00% | 2q | +18.3%+$162.3K |
| MetLife Investment Management, LLC | $1.0M | 18,250 | 0.00% | 5q | +13.9%+$123.2K |
| Russell Investments Group, Ltd. | $1.0M | 18,162 | 0.00% | 5q | +371.0%+$789.7K |
| Koa Wealth Management, LLC | $944.6K | 17,113 | 0.64% | 6q | -4.5%-$44.2K |
| ALLIANCEBERNSTEIN L.P. | $925.4K | 31,000 | 0.00% | 5q | +1.6%+$14.9K |
| STATE OF WISCONSIN INVESTMENT BOARD | $881.6K | 15,971 | 0.00% | 2q | -17.1%-$181.7K |
| VANGUARD ASSET MANAGEMENT, Ltd | $814.3K | 14,752 | 0.00% | 2q | HELD |
| Sound Capital Solutions LLC | $798.1K | 14,458 | 0.19% | new | FIRST |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $788.9K | 14,292 | 0.00% | 7q | +7.3%+$53.4K |
| DAFNA Capital Management LLC | $651.9K | 11,809 | 0.12% | 4q | -93.3%-$9.0M |
| HighVista Strategies LLC | $642.2K | 11,634 | 0.15% | 2q | +1.4%+$8.9K |
| NEW YORK STATE COMMON RETIREMENT FUND | $607.2K | 11,000 | 0.00% | 6q | +22.2%+$110.4K |
| Jupiter Topco LLC | $568.3K | 10,300 | 0.00% | new | FIRST |
| FRED ALGER MANAGEMENT, LLC | $545.2K | 9,877 | 0.00% | new | NEW |
| BNP PARIBAS FINANCIAL MARKETS | $544.3K | 9,860 | 0.00% | 7q | -5.0%-$28.9K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $539.7K | 9,777 | 0.00% | new | NEW |
| Virtus Investment Advisers, LLC | $508.7K | 9,215 | 0.12% | 6q | +0.9%+$4.6K |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | Deep Track Capital, LPwith 2 co-filers | 3.6% |
| 2026-08-10 | 13D/A | ORBIMED ADVISORS LLCwith 2 co-filers | 6.4% |
| 2026-08-10 | 13D/A | James N. Topper INDIVIDUALwith 10 co-filers | 11.7% |
| 2026-07-29 | 13G | BlackRock, Inc. | 5.5% |
| 2026-07-08 | 13G/A | FMR LLCwith 1 co-filers | 11.2% |
| 2026-07-08 | 13G/A | Wellington Management Group LLPwith 3 co-filers | 10.5% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 171 | $3.1B | 54,854,876 | 38 | 58 | 46 | 1.1% |
| Q1 2026 | 152 | $1.6B | 52,040,587 | 31 | 42 | 45 | 0.3% |
| Q4 2025 | 132 | $1.5B | 47,510,911 | 33 | 50 | 25 | 1.2% |
| Q3 2025 | 122 | $861.0M | 46,833,164 | 46 | 29 | 28 | 4.8% |
| Q2 2025 | 86 | $407.1M | 35,525,293 | 22 | 38 | 13 | 0.4% |
| Q1 2025 | 75 | $255.2M | 34,581,591 | 24 | 23 | 12 | 0.0% |
| Q4 2024 | 60 | $584.6M | 31,753,095 | 30 | 11 | 7 | 0.0% |
| Q3 2024 | 42 | $751.8M | 29,064,158 | 41 | 0 | 0 | 0.0% |