LEXICON PHARMACEUTICALS INC (LXRX)
Institutional ownership reported to the SEC as of Q2 2026, across 31 quarters.
145
Reporting holders
$881.3M
Reported value
82.0%
Of shares outstanding
0.6%
Held as options
+15
Holder change
Institutions report 365,065,719 shares against 444,955,934 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| Artal Group S.A. | $420.4M | 175,156,062 | 45.15% | 31q | +13.2%+$49.0M |
| FMR LLC | $124.3M | 51,782,045 | 0.01% | 31q | +14.9%+$16.1M |
| Siren, L.L.C. | $106.3M | 44,303,518 | 2.15% | 8q | HELD |
| Sessa Capital IM, L.P. | $45.5M | 18,960,836 | 0.76% | 5q | +5.8%+$2.5M |
| BlackRock, Inc. | $41.6M | 17,348,741 | 0.00% | 8q | +422.2%+$33.7M |
| VANGUARD CAPITAL MANAGEMENT LLC | $23.8M | 9,901,208 | 0.00% | 2q | +4.0%+$916.9K |
| Point72 Asset Management, L.P. | $19.8M | 8,251,325 | 0.02% | 3q | +5.6%+$1.0M |
| GEODE CAPITAL MANAGEMENT, LLC | $15.0M | 6,244,372 | 0.00% | 31q | +97.0%+$7.4M |
| STATE STREET CORP | $11.8M | 4,917,769 | 0.00% | 31q | +410.1%+$9.5M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $5.7M | 2,357,749 | 0.00% | 2q | +331.3%+$4.3M |
| CITADEL ADVISORS LLC | $4.8M | 1,601,182 | 0.00% | 31q | +46.2%+$1.5M |
| NORTHERN TRUST CORP | $4.7M | 1,968,619 | 0.00% | 31q | +298.0%+$3.5M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4.7M | 1,956,775 | 0.00% | 31q | +49.2%+$1.5M |
| Sixth Street Partners Management Company, L.P. | $4.7M | 1,956,775 | 0.00% | new | NEW |
| VANGUARD FIDUCIARY TRUST CO | $3.9M | 1,634,571 | 0.00% | 2q | +22.7%+$725.5K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3.3M | 696,776 | 0.00% | 31q | -67.2%-$6.8M |
| Ishara Investments LP | $3.1M | 1,271,000 | 2.24% | 3q | +40.9%+$885.6K |
| MILLENNIUM MANAGEMENT LLC | $2.7M | 1,134,229 | 0.00% | 6q | -77.1%-$9.1M |
| RENAISSANCE TECHNOLOGIES LLC | $2.7M | 1,127,000 | 0.00% | 4q | -29.6%-$1.1M |
| MACKENZIE FINANCIAL CORP | $2.3M | 963,354 | 0.00% | 2q | +24.7%+$457.6K |
| ADAR1 Capital Management, LLC | $1.8M | 750,000 | 0.08% | 2q | HELD |
| UBS Group AG | $1.6M | 684,713 | 0.00% | 31q | -72.4%-$4.3M |
| GROUP ONE TRADING LLC | $1.6M | 175,013 | 0.00% | 31q | -5.4%-$90.1K |
| TWO SIGMA INVESTMENTS, LP | $1.5M | 643,444 | 0.00% | 5q | -46.4%-$1.3M |
| Nuveen, LLC | $1.4M | 586,664 | 0.00% | new | NEW |
| JANE STREET GROUP, LLC | $1.4M | options only | 0.00% | 5q | OPTIONS |
| Bank of New York Mellon Corp | $1.4M | 568,706 | 0.00% | 31q | +1971.1%+$1.3M |
| Invesco Ltd. | $1.2M | 508,071 | 0.00% | 25q | -0.8%-$10.5K |
| GOLDMAN SACHS GROUP INC | $1.2M | 485,546 | 0.00% | 31q | -54.6%-$1.4M |
| Compagnie Lombard Odier SCmA | $1.2M | 480,000 | 0.01% | 31q | -5.9%-$72.0K |
| BANK OF AMERICA CORP /DE/ | $1.0M | 421,299 | 0.00% | 31q | -19.9%-$251.5K |
| BARCLAYS PLC | $930.0K | 387,483 | 0.00% | 31q | +267.3%+$676.8K |
| XTX Topco Ltd | $858.9K | 357,877 | 0.01% | 6q | +13.8%+$103.8K |
| CANADA PENSION PLAN INVESTMENT BOARD | $619.0K | 257,900 | 0.00% | new | NEW |
| RHUMBLINE ADVISERS | $616.5K | 256,885 | 0.00% | 4q | HELD |
| DEUTSCHE BANK AG\ | $594.1K | 247,528 | 0.00% | new | NEW |
| WELLS FARGO & COMPANY/MN | $553.1K | 230,470 | 0.00% | 14q | +1385.0%+$515.9K |
| WELLINGTON MANAGEMENT GROUP LLP | $431.3K | 179,700 | 0.00% | new | NEW |
| CITIGROUP INC | $420.5K | 175,205 | 0.00% | 31q | +5.3%+$21.1K |
| Virtus Investment Advisers, LLC | $409.0K | 170,415 | 0.10% | new | NEW |
| Headlands Technologies LLC | $401.3K | 167,198 | 0.04% | 4q | -12.6%-$57.9K |
| Ikarian Capital, LLC | $395.2K | 164,674 | 0.04% | 7q | HELD |
| Quarry LP | $374.8K | 156,186 | 0.03% | 3q | +42.0%+$110.8K |
| MetLife Investment Management, LLC | $351.4K | 146,410 | 0.00% | new | NEW |
| MORGAN STANLEY | $319.0K | 132,902 | 0.00% | 35q | -39.6%-$208.7K |
| PANAGORA ASSET MANAGEMENT INC | $316.9K | 132,042 | 0.00% | new | NEW |
| JPMORGAN CHASE & CO | $290.0K | 109,839 | 0.00% | new | NEW |
| State of Wyoming | $285.8K | 119,090 | 0.03% | 4q | +1004.8%+$259.9K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $273.9K | 114,114 | 0.00% | new | NEW |
| Cornerstone Investment Partners, LLC | $273.0K | 113,739 | 0.01% | new | NEW |
| Cerity Partners LLC | $236.2K | 98,400 | 0.00% | 10q | -10.9%-$28.9K |
| ALGERT GLOBAL LLC | $221.2K | 92,150 | 0.00% | new | NEW |
| BANK OF NOVA SCOTIA | $207.9K | 86,607 | 0.00% | 2q | +17.5%+$31.0K |
| LPL Financial LLC | $203.8K | 84,916 | 0.00% | 18q | +21.7%+$36.3K |
| SIMPLEX TRADING, LLC | $199.3K | 8,540 | 0.00% | 21q | HELD |
| Vanguard Global Advisers, LLC | $187.1K | 77,946 | 0.00% | 2q | -16.8%-$37.7K |
| AQR CAPITAL MANAGEMENT LLC | $180.6K | 75,230 | 0.00% | 6q | -21.8%-$50.4K |
| Police & Firemen's Retirement System of New Jersey | $176.2K | 73,402 | 0.00% | new | NEW |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | $171.4K | 71,427 | 0.02% | 30q | +100.0%+$85.7K |
| PRUDENTIAL FINANCIAL INC | $171.2K | 71,345 | 0.00% | 4q | +111.1%+$90.1K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $167.4K | 69,747 | 0.00% | new | NEW |
| NEW YORK STATE COMMON RETIREMENT FUND | $164.2K | 68,400 | 0.00% | new | NEW |
| TWO SIGMA SECURITIES, LLC | $159.3K | 66,375 | 0.01% | new | NEW |
| SEI INVESTMENTS CO | $153.4K | 63,937 | 0.00% | new | NEW |
| Straight Path Wealth Management | $150.4K | 62,666 | 0.04% | 6q | HELD |
| R Squared Ltd | $132.0K | 54,985 | 0.07% | 5q | -18.6%-$30.1K |
| Vanguard Personalized Indexing Management, LLC | $130.4K | 54,334 | 0.00% | 11q | -1.1%-$1.5K |
| Aster Capital Management (DIFC) Ltd | $125.2K | 131,195 | 0.01% | new | NEW |
| Fortis Group Advisors, LLC | $120.0K | 50,000 | 0.02% | 6q | HELD |
| Schonfeld Strategic Advisors LLC | $118.6K | 49,435 | 0.00% | 10q | -34.2%-$61.6K |
| SCOTIA CAPITAL INC. | $117.3K | 48,871 | 0.00% | 2q | -69.4%-$266.3K |
| PROFUND ADVISORS LLC | $116.6K | 48,586 | 0.00% | new | NEW |
| VOYA INVESTMENT MANAGEMENT LLC | $114.7K | 47,771 | 0.00% | new | NEW |
| AXQ CAPITAL, LP | $109.7K | 45,727 | 0.01% | 2q | +126.9%+$61.4K |
| BOOTHBAY FUND MANAGEMENT, LLC | $106.4K | 44,315 | 0.00% | 7q | HELD |
| ALLIANCEBERNSTEIN L.P. | $105.8K | 67,800 | 0.00% | new | NEW |
| WINTON GROUP Ltd | $103.7K | 43,200 | 0.00% | 2q | +69.4%+$42.5K |
| INTECH INVESTMENT MANAGEMENT LLC | $102.0K | 42,491 | 0.00% | new | NEW |
| LMR Partners LLP | $98.6K | 41,091 | 0.00% | 2q | +76.3%+$42.7K |
| BANK OF MONTREAL /CAN/ | $96.0K | 40,000 | 0.00% | 10q | -42.9%-$72.0K |
| BNP PARIBAS FINANCIAL MARKETS | $90.7K | 37,780 | 0.00% | 31q | +115.3%+$48.6K |
| Rafferty Asset Management, LLC | $81.8K | 34,090 | 0.00% | new | NEW |
| ProShare Advisors LLC | $78.2K | 32,588 | 0.00% | new | NEW |
| Leonteq Securities AG | $72.0K | 30,000 | 0.00% | 3q | HELD |
| Pathstone Holdings, LLC | $71.9K | 29,969 | 0.00% | 11q | +0.7% |
| PINNACLE ASSOCIATES LTD | $69.6K | 29,015 | 0.00% | 31q | HELD |
| VICTORY CAPITAL MANAGEMENT INC | $58.1K | 24,223 | 0.00% | 23q | +6.8%+$3.7K |
| Legal & General Group Plc | $58.0K | 24,185 | 0.00% | new | NEW |
| XPONANCE LLC | $57.0K | 23,763 | 0.00% | new | NEW |
| Graham Capital Management, L.P. | $56.5K | 23,541 | 0.00% | 3q | -30.8%-$25.2K |
| Ameritas Investment Partners, Inc. | $55.2K | 22,986 | 0.00% | new | NEW |
| D. E. Shaw & Co., Inc. | $53.3K | 22,200 | 0.00% | new | NEW |
| Quadrature Capital Ltd | $52.8K | 21,998 | 0.00% | 4q | -80.1%-$212.1K |
| TIAA-CREF INDIVIDUAL & INSTITUTIONAL SERVICES, LLC | $48.0K | 20,000 | 0.00% | 2q | HELD |
| DIKER MANAGEMENT LLC | $48.0K | 20,000 | 0.04% | 2q | HELD |
| Invera Wealth Advisors, LLC | $48.0K | 20,000 | 0.03% | 6q | HELD |
| Russell Investments Group, Ltd. | $47.8K | 19,902 | 0.00% | new | NEW |
| Tower Research Capital LLC (TRC) | $46.8K | 19,486 | 0.00% | new | NEW |
| SBI Securities Co., Ltd. | $46.1K | 19,205 | 0.00% | 7q | +370.6%+$36.3K |
| PRINCIPAL FINANCIAL GROUP INC | $45.7K | 19,034 | 0.00% | new | NEW |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-06 | 13G/A | FMR LLCwith 1 co-filers | 11.7% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 145 | $881.3M | 365,065,719 | 43 | 35 | 34 | 0.6% |
| Q1 2026 | 130 | $505.7M | 321,826,110 | 26 | 40 | 24 | 0.7% |
| Q4 2025 | 115 | $298.8M | 258,559,002 | 19 | 26 | 38 | 0.5% |
| Q3 2025 | 114 | $346.5M | 253,669,997 | 18 | 23 | 36 | 1.2% |
| Q2 2025 | 113 | $240.8M | 253,264,163 | 23 | 27 | 34 | 0.3% |
| Q1 2025 | 119 | $121.9M | 263,811,936 | 30 | 29 | 30 | 0.2% |
| Q4 2024 | 119 | $220.3M | 297,072,622 | 18 | 40 | 21 | 0.3% |
| Q3 2024 | 126 | $454.1M | 287,745,234 | 19 | 42 | 21 | 0.5% |
| Q2 2024 | 119 | $479.0M | 280,981,604 | 21 | 41 | 20 | 1.0% |
| Q1 2024 | 106 | $431.7M | 172,354,589 | 27 | 27 | 29 | 3.5% |
| Q4 2023 | 96 | $104.7M | 67,866,475 | 21 | 27 | 19 | 0.9% |
| Q3 2023 | 101 | $77.6M | 70,543,771 | 6 | 43 | 28 | 0.9% |
| Q2 2023 | 108 | $168.4M | 72,752,323 | 25 | 47 | 16 | 1.0% |
| Q1 2023 | 83 | $145.1M | 59,500,531 | 8 | 32 | 26 | 0.4% |
| Q4 2022 | 79 | $92.7M | 48,383,975 | 7 | 27 | 20 | 0.3% |
| Q3 2022 | 97 | $358.0M | 148,995,910 | 21 | 39 | 21 | 0.1% |
| Q2 2022 | 87 | $222.1M | 119,037,933 | 4 | 26 | 27 | 0.3% |
| Q1 2022 | 103 | $251.6M | 120,214,571 | 6 | 29 | 38 | 0.1% |
| Q4 2021 | 111 | $481.3M | 121,781,552 | 21 | 34 | 28 | 0.3% |
| Q3 2021 | 97 | $584.8M | 121,205,858 | 8 | 30 | 34 | 0.3% |
| Q2 2021 | 109 | $545.7M | 117,994,589 | 27 | 40 | 24 | 0.8% |
| Q1 2021 | 109 | $715.5M | 121,215,452 | 25 | 29 | 29 | 0.5% |
| Q4 2020 | 106 | $423.7M | 122,120,021 | 27 | 23 | 31 | 1.4% |
| Q3 2020 | 92 | $150.6M | 104,251,476 | 5 | 29 | 27 | 0.3% |
| Q2 2020 | 107 | $214.3M | 107,197,140 | 19 | 36 | 22 | 0.2% |
| Q1 2020 | 109 | $205.1M | 104,891,556 | 20 | 35 | 27 | 0.3% |
| Q4 2019 | 116 | $450.8M | 107,984,454 | 24 | 32 | 30 | 0.6% |
| Q3 2019 | 104 | $313.5M | 103,239,015 | 16 | 20 | 28 | 0.9% |
| Q2 2019 | 112 | $674.5M | 106,288,913 | 8 | 30 | 34 | 0.9% |
| Q1 2019 | 122 | $588.1M | 104,460,131 | 14 | 37 | 34 | 1.1% |
| Q4 2018 | 122 | $706.5M | 105,939,622 | 3 | 2 | 2 | 0.4% |