KARYOPHARM THERAPEUTICS INC (KPTI)
Institutional ownership reported to the SEC as of Q2 2026, across 31 quarters.
97
Reporting holders
$219.4M
Reported value
91.0%
Of shares outstanding
8.1%
Held as options
+16
Holder change
Institutions report 20,638,466 shares against 22,681,460 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | $18.7M | 1,917,354 | 0.16% | 2q | HELD |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $14.9M | 1,521,322 | 0.02% | 6q | -15.8%-$2.8M |
| ACORN CAPITAL ADVISORS, LLC | $14.8M | 1,518,113 | 4.05% | 2q | +427.4%+$12.0M |
| GOLDMAN SACHS GROUP INC | $13.9M | 1,424,658 | 0.00% | 2q | +50.3%+$4.7M |
| BlackRock, Inc. | $13.9M | 1,418,799 | 0.00% | 6q | +479.3%+$11.5M |
| Kalehua Capital Management LLC | $13.4M | 1,371,288 | 4.27% | new | NEW |
| VANGUARD CAPITAL MANAGEMENT LLC | $9.4M | 958,979 | 0.00% | 2q | +29.6%+$2.1M |
| Catalio Capital Management, LP | $9.2M | 940,855 | 1.73% | 6q | +4.8%+$421.5K |
| Avidity Partners Management LP | $9.0M | 924,487 | 1.45% | 6q | HELD |
| TWO SIGMA INVESTMENTS, LP | $6.8M | 695,264 | 0.00% | 3q | +359.7%+$5.3M |
| NEA Management Company, LLC | $5.6M | 576,780 | 0.35% | new | NEW |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5.3M | options only | 0.00% | 6q | OPTIONS |
| GEODE CAPITAL MANAGEMENT, LLC | $5.2M | 531,231 | 0.00% | 6q | +157.7%+$3.2M |
| Ghisallo Capital Management LLC | $4.9M | 500,000 | 0.10% | new | NEW |
| Soleus Capital Management, L.P. | $4.3M | 440,000 | 0.15% | 3q | HELD |
| Caption Management, LLC | $3.7M | options only | 0.02% | 2q | OPTIONS |
| UBS Group AG | $3.5M | 353,545 | 0.00% | 6q | +82.2%+$1.6M |
| MILLENNIUM MANAGEMENT LLC | $3.3M | 305,676 | 0.00% | 2q | -27.3%-$1.3M |
| STATE STREET CORP | $3.2M | 325,991 | 0.00% | 6q | +303.7%+$2.4M |
| Affinity Asset Advisors, LLC | $3.1M | 312,500 | 0.14% | 5q | -37.5%-$1.8M |
| Brevan Howard Capital Management LP | $3.0M | 309,817 | 0.02% | 2q | +45.9%+$952.1K |
| Boxer Capital Management, LLC | $3.0M | 302,536 | 0.22% | 3q | HELD |
| Davidson Kempner Capital Management LP | $2.9M | 300,000 | 0.03% | 3q | HELD |
| SILVERARC CAPITAL MANAGEMENT, LLC | $2.9M | 297,460 | 0.30% | new | NEW |
| Eversept Partners, LP | $2.7M | 276,174 | 0.14% | 2q | HELD |
| Tetragon Partners GP Ltd | $2.4M | options only | 0.39% | 2q | OPTIONS |
| JPMORGAN CHASE & CO | $2.2M | 207,609 | 0.00% | 6q | +43978.3%+$2.2M |
| MORGAN STANLEY | $2.0M | 202,506 | 0.00% | 6q | +990.5%+$1.8M |
| Trexquant Investment LP | $1.8M | 188,368 | 0.01% | 3q | -27.0%-$679.4K |
| BNP PARIBAS FINANCIAL MARKETS | $1.8M | 188,038 | 0.00% | 6q | +223754.8%+$1.8M |
| DLD Asset Management, LP | $1.8M | options only | 0.12% | new | OPTIONS |
| BARCLAYS PLC | $1.6M | 165,904 | 0.00% | 6q | +2134.7%+$1.5M |
| NORTHERN TRUST CORP | $1.6M | 160,006 | 0.00% | 6q | +315.0%+$1.2M |
| VANGUARD FIDUCIARY TRUST CO | $1.4M | 145,401 | 0.00% | 2q | +26.5%+$297.7K |
| J. Goldman & Co LP | $1.3M | 67,500 | 0.03% | new | NEW |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $1.3M | 134,818 | 0.00% | new | NEW |
| SILVERBACK ASSET MANAGEMENT LLC | $1.3M | 30,000 | 0.14% | 6q | -53.8%-$1.5M |
| MARSHALL WACE, LLP | $1.3M | 128,451 | 0.00% | 6q | HELD |
| GROUP ONE TRADING LLC | $1.2M | options only | 0.00% | 6q | OPTIONS |
| CITADEL ADVISORS LLC | $1.2M | 52,069 | 0.00% | 6q | HELD |
| RENAISSANCE TECHNOLOGIES LLC | $1.1M | 108,214 | 0.00% | 6q | +2.7%+$27.4K |
| Jump Financial, LLC | $918.4K | 94,000 | 0.01% | 3q | -64.1%-$1.6M |
| Invesco Ltd. | $882.3K | 90,304 | 0.00% | 2q | +439.5%+$718.7K |
| JANE STREET GROUP, LLC | $842.9K | 33,173 | 0.00% | 4q | -68.7%-$1.8M |
| Connor, Clark & Lunn Investment Management Ltd. | $746.4K | 76,397 | 0.00% | 3q | -3.4%-$26.2K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $702.2K | 71,873 | 0.01% | 5q | HELD |
| Squarepoint Ops LLC | $623.3K | 63,801 | 0.00% | new | NEW |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $605.2K | 61,943 | 0.00% | 2q | +361.3%+$474.0K |
| Sixth Street Partners Management Company, L.P. | $605.2K | 61,943 | 0.00% | new | NEW |
| ROYAL BANK OF CANADA | $590.0K | 60,430 | 0.00% | 6q | HELD |
| Bank of New York Mellon Corp | $559.4K | 57,262 | 0.00% | 6q | +402.3%+$448.1K |
| Susquehanna Portfolio Strategies, LLC | $532.9K | 54,545 | 0.01% | 2q | +118.0%+$288.4K |
| XTX Topco Ltd | $520.5K | 53,272 | 0.01% | 5q | -67.6%-$1.1M |
| BANK OF AMERICA CORP /DE/ | $487.8K | 49,924 | 0.00% | 6q | +156.4%+$297.5K |
| CITIGROUP INC | $370.4K | 37,917 | 0.00% | 6q | +667.4%+$322.2K |
| Nuveen, LLC | $370.0K | 37,868 | 0.00% | new | NEW |
| Engineers Gate Manager LP | $331.8K | 33,966 | 0.00% | 2q | -69.8%-$766.6K |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $326.0K | 33,333 | 0.00% | new | NEW |
| SIMPLEX TRADING, LLC | $323.2K | 24,086 | 0.00% | new | NEW |
| TORONTO DOMINION BANK | $302.2K | 30,930 | 0.00% | new | NEW |
| Baird Financial Group, Inc. | $291.1K | 29,791 | 0.00% | 5q | HELD |
| ExodusPoint Capital Management, LP | $259.7K | 26,582 | 0.00% | new | NEW |
| China Universal Asset Management Co., Ltd. | $244.2K | 25,000 | 0.01% | 2q | -16.7%-$48.9K |
| RHUMBLINE ADVISERS | $229.3K | 23,467 | 0.00% | new | NEW |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $227.3K | 23,265 | 0.00% | new | NEW |
| Velan Capital Investment Management LP | $195.4K | 20,000 | 0.12% | 2q | +33.3%+$48.9K |
| DEUTSCHE BANK AG\ | $189.8K | 19,425 | 0.00% | new | NEW |
| WELLS FARGO & COMPANY/MN | $165.1K | 16,903 | 0.00% | new | NEW |
| SEI INVESTMENTS CO | $147.4K | 15,083 | 0.00% | new | NEW |
| HSBC HOLDINGS PLC | $137.4K | 13,750 | 0.00% | 2q | +19.6%+$22.5K |
| Headlands Technologies LLC | $118.3K | 12,113 | 0.01% | new | NEW |
| MetLife Investment Management, LLC | $117.4K | 12,017 | 0.00% | new | NEW |
| Y-Intercept (Hong Kong) Ltd | $101.4K | 10,375 | 0.00% | new | NEW |
| Quadrature Capital Ltd | $100.6K | 10,296 | 0.00% | new | NEW |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $89.6K | 9,171 | 0.00% | new | NEW |
| FMR LLC | $87.3K | 8,936 | 0.00% | 6q | +1243.8%+$80.8K |
| Vanguard Global Advisers, LLC | $80.2K | 8,207 | 0.00% | 2q | HELD |
| Police & Firemen's Retirement System of New Jersey | $57.4K | 5,874 | 0.00% | new | NEW |
| NEW YORK STATE COMMON RETIREMENT FUND | $54.7K | 5,600 | 0.00% | new | NEW |
| TD Waterhouse Canada Inc. | $54.5K | 5,707 | 0.00% | 6q | +78.2%+$23.9K |
| Legal & General Group Plc | $18.9K | 1,935 | 0.00% | new | NEW |
| Ameritas Investment Partners, Inc. | $17.7K | 1,808 | 0.00% | new | NEW |
| Russell Investments Group, Ltd. | $15.6K | 1,592 | 0.00% | new | NEW |
| Tower Research Capital LLC (TRC) | $12.3K | 1,259 | 0.00% | new | NEW |
| T. Rowe Price Investment Management, Inc. | $7.7K | 786,309 | 0.01% | 6q | -49.0%-$7.4K |
| OSAIC HOLDINGS, INC. | $3.9K | 402 | 0.00% | 6q | HELD |
| Sterling Capital Management LLC | $3.4K | 352 | 0.00% | new | NEW |
| ACADIAN ASSET MANAGEMENT LLC | $2.9K | 298,997 | 0.00% | 3q | +20.1% |
| HARBOUR INVESTMENTS, INC. | $2.8K | 285 | 0.00% | 6q | HELD |
| Quent Capital, LLC | $1.6K | 166 | 0.00% | 4q | -29.4% |
| Integrated Wealth Concepts LLC | $1.3K | 134 | 0.00% | new | NEW |
| C WorldWide Group Holding A/S | $977 | 100,000 | 0.02% | 6q | HELD |
| MB, LEVIS & ASSOCIATES, LLC | $977 | 100 | 0.00% | 6q | HELD |
| SBI Securities Co., Ltd. | $655 | 67 | 0.00% | 6q | HELD |
| Activest Wealth Management | $645 | 66 | 0.00% | 6q | HELD |
| PRICE T ROWE ASSOCIATES INC /MD/ | $266 | 27,225 | 0.00% | 5q | +150.1% |
| Allworth Financial LP | $255 | 26 | 0.00% | 6q | HELD |
| MERCER GLOBAL ADVISORS INC /ADV | $137 | 14 | 0.00% | new | NEW |
| Caitong International Asset Management Co., Ltd | $137 | 14 | 0.00% | new | NEW |
| Virtu Financial LLC | $105 | 10,728 | 0.00% | new | NEW |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | RA Capital Management, L.P.with 3 co-filers | 9.9% |
| 2026-08-14 | 13G/A | Commodore Capital LPwith 3 co-filers | 0.0% |
| 2026-08-12 | 13G/A | Adage Capital Management, L.P.with 2 co-filers | 6.8% |
| 2026-08-11 | 13G/A | THE GOLDMAN SACHS GROUP, INC.with 1 co-filers | 6.3% |
| 2026-07-28 | 13G | BlackRock, Inc. | 5.6% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 97 | $219.4M | 20,638,466 | 35 | 27 | 14 | 8.1% |
| Q1 2026 | 81 | $139.0M | 16,213,323 | 26 | 30 | 11 | 34.4% |
| Q4 2025 | 66 | $67.3M | 7,860,153 | 23 | 17 | 6 | 14.2% |
| Q3 2025 | 52 | $34.5M | 2,116,683 | 10 | 6 | 18 | 59.9% |
| Q2 2025 | 47 | $16.9M | 3,530,354 | 9 | 12 | 5 | 10.2% |
| Q1 2025 | 48 | $12.0M | 3,082,453 | 51 | 0 | 0 | 3.6% |
| Q4 2024 | 2 | $30.1K | 0 | 0 | 0 | 0 | 100.0% |
| Q3 2024 | 2 | $584.9K | 0 | 0 | 0 | 0 | 100.0% |
| Q2 2024 | 2 | $611.6K | 0 | 0 | 0 | 0 | 100.0% |
| Q1 2024 | 2 | $70.4K | 0 | 1 | 0 | 0 | 100.0% |
| Q4 2023 | 2 | $77.5K | 0 | 1 | 0 | 0 | 100.0% |
| Q3 2023 | 2 | $179.6K | 0 | 0 | 0 | 0 | 100.0% |
| Q2 2023 | 3 | $188.7K | 0 | 0 | 0 | 0 | 100.0% |
| Q1 2023 | 3 | $143.6K | 0 | 1 | 0 | 0 | 100.0% |
| Q4 2022 | 3 | $992.9K | 0 | 0 | 0 | 0 | 100.0% |
| Q3 2022 | 3 | $2.0M | 0 | 0 | 0 | 0 | 100.0% |
| Q2 2022 | 3 | $2.7M | 0 | 2 | 0 | 0 | 100.0% |
| Q1 2022 | 3 | $4.6M | 0 | 1 | 0 | 0 | 100.0% |
| Q4 2021 | 2 | $3.2M | 0 | 0 | 0 | 0 | 100.0% |
| Q3 2021 | 2 | $1.2M | 0 | 0 | 0 | 0 | 100.0% |
| Q2 2021 | 2 | $2.1M | 0 | 2 | 0 | 0 | 100.0% |
| Q1 2021 | 1 | $2.2M | 0 | 0 | 0 | 0 | 100.0% |
| Q4 2020 | 3 | $3.8M | 0 | 0 | 0 | 0 | 100.0% |
| Q3 2020 | 2 | $4.3M | 0 | 0 | 0 | 0 | 100.0% |
| Q2 2020 | 3 | $5.5M | 0 | 0 | 0 | 0 | 100.0% |
| Q1 2020 | 4 | $10.3M | 0 | 1 | 0 | 0 | 100.0% |
| Q4 2019 | 3 | $8.3M | 0 | 0 | 0 | 0 | 100.0% |
| Q3 2019 | 3 | $1.6M | 0 | 1 | 0 | 0 | 100.0% |
| Q2 2019 | 3 | $336.0K | 270 | 1 | 0 | 0 | 100.0% |
| Q1 2019 | 4 | $2.0M | 0 | 2 | 0 | 0 | 100.0% |
| Q4 2018 | 2 | $225.0K | 0 | 0 | 0 | 0 | 100.0% |