IONIS PHARMACEUTICALS INC (IONS)
Institutional ownership reported to the SEC as of Q2 2026, across 31 quarters.
491
Reporting holders
$14.3B
Reported value
103.5%
Of shares outstanding
4.5%
Held as options
+24
Holder change
Institutions report 172,058,684 shares against 166,184,322 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $2.0B | 24,631,956 | 0.08% | 31q | HELD |
| Capital World Investors | $1.7B | 21,669,226 | 0.20% | 13q | +2.3%+$38.3M |
| BlackRock, Inc. | $848.8M | 10,704,660 | 0.01% | 8q | +2.5%+$20.8M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $623.2M | 7,859,529 | 0.03% | 2q | +0.6%+$4.0M |
| WELLINGTON MANAGEMENT GROUP LLP | $606.7M | 7,651,415 | 0.10% | 13q | +19.7%+$99.9M |
| VANGUARD CAPITAL MANAGEMENT LLC | $571.8M | 7,211,497 | 0.01% | 2q | +1.3%+$7.4M |
| TWO SIGMA INVESTMENTS, LP | $495.7M | 6,252,342 | 0.36% | 31q | +6.7%+$31.3M |
| ROYAL BANK OF CANADA | $490.2M | 6,182,479 | 0.07% | 31q | +62.6%+$188.8M |
| STATE STREET CORP | $343.7M | 4,334,848 | 0.01% | 31q | +8.5%+$26.9M |
| GEODE CAPITAL MANAGEMENT, LLC | $294.8M | 3,584,024 | 0.02% | 31q | -10.0%-$32.9M |
| JPMORGAN CHASE & CO | $242.8M | 2,671,717 | 0.01% | 31q | +13.0%+$28.0M |
| Artisan Partners Limited Partnership | $209.3M | 2,640,024 | 0.33% | 10q | +28.3%+$46.1M |
| Tweedy, Browne Co LLC | $180.8M | 2,280,311 | 13.70% | 18q | HELD |
| Deep Track Capital, LP | $174.4M | 2,200,000 | 2.54% | 15q | +12.8%+$19.8M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $168.6M | 3,839 | 0.01% | 31q | -68.9%-$374.2M |
| GOLDMAN SACHS GROUP INC | $167.3M | 2,109,945 | 0.01% | 31q | +24.1%+$32.5M |
| BAKER BROS. ADVISORS LP | $162.4M | 2,047,727 | 0.81% | 4q | HELD |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $157.0M | 1,979,669 | 1.64% | 4q | HELD |
| AMERICAN CENTURY COMPANIES INC | $154.4M | 1,947,076 | 0.07% | 6q | +17.0%+$22.5M |
| BARCLAYS PLC | $131.1M | 1,603,136 | 0.03% | 31q | +453.0%+$107.4M |
| FRANKLIN RESOURCES INC | $128.7M | 1,623,377 | 0.03% | 5q | +3.1%+$3.8M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $127.3M | 1,605,054 | 0.02% | 31q | +1.4%+$1.7M |
| Sixth Street Partners Management Company, L.P. | $127.3M | 1,605,054 | 0.02% | new | NEW |
| JANE STREET GROUP, LLC | $127.1M | 503,647 | 0.01% | 31q | +162.6%+$78.7M |
| Pictet Asset Management Holding SA | $127.0M | 1,596,998 | 0.12% | 12q | +11.3%+$12.9M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $115.3M | 1,454,672 | 0.02% | 31q | -1.4%-$1.7M |
| Polar Capital Holdings Plc | $115.3M | 1,454,021 | 0.27% | 5q | +75.3%+$49.5M |
| Alyeska Investment Group, L.P. | $112.4M | 1,417,916 | 0.29% | 5q | +199.7%+$74.9M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $103.1M | 1,300,392 | 0.15% | 3q | +65.6%+$40.8M |
| MORGAN STANLEY | $101.6M | 1,281,444 | 0.01% | 35q | +24.8%+$20.2M |
| Invesco Ltd. | $88.9M | 1,120,707 | 0.01% | 31q | -12.3%-$12.4M |
| VANGUARD FIDUCIARY TRUST CO | $84.1M | 1,060,845 | 0.02% | 2q | +3.6%+$2.9M |
| Caption Management, LLC | $77.5M | 1,759 | 0.36% | 9q | -88.7%-$609.6M |
| Bellevue Group AG | $77.1M | 972,258 | 1.62% | 31q | -46.5%-$67.1M |
| GROUPAMA ASSET MANAGMENT | $75.2M | 937,083 | 0.95% | 11q | +13.6%+$9.0M |
| NORTHERN TRUST CORP | $72.4M | 913,610 | 0.01% | 31q | +5.2%+$3.6M |
| CITADEL ADVISORS LLC | $67.8M | 236,284 | 0.01% | 31q | -74.9%-$202.7M |
| Capital International Investors | $65.3M | 823,764 | 0.01% | new | NEW |
| Davern Capital Partners, LP | $63.3M | 798,709 | 10.80% | 3q | +106.4%+$32.7M |
| BANK OF AMERICA CORP /DE/ | $62.7M | 790,990 | 0.00% | 31q | -5.9%-$3.9M |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | $62.4M | 787,263 | 1.10% | 4q | -43.9%-$48.9M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $58.2M | 734,219 | 0.06% | 11q | -19.1%-$13.7M |
| Nuveen, LLC | $57.6M | 726,282 | 0.01% | 6q | +12.0%+$6.2M |
| Ikarian Capital, LLC | $55.5M | options only | 5.98% | 4q | OPTIONS |
| Connor, Clark & Lunn Investment Management Ltd. | $54.3M | 684,236 | 0.10% | 9q | -21.7%-$15.1M |
| Eversept Partners, LP | $52.7M | 664,684 | 2.73% | 21q | +5.2%+$2.6M |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $52.0M | 655,454 | 0.22% | 8q | -2.6%-$1.4M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $51.7M | 651,816 | 0.02% | 5q | -2.1%-$1.1M |
| NEUBERGER BERMAN GROUP LLC | $50.2M | 633,533 | 0.03% | 17q | +42.9%+$15.1M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $50.1M | 632,028 | 0.02% | 4q | -14.3%-$8.4M |
| UBS Group AG | $49.5M | 624,874 | 0.01% | 31q | -22.7%-$14.6M |
| TimesSquare Capital Management, LLC | $48.7M | 614,070 | 0.72% | 2q | +122.8%+$26.8M |
| EVENTIDE ASSET MANAGEMENT, LLC | $45.6M | 575,000 | 0.61% | 3q | HELD |
| PERCEPTIVE ADVISORS LLC | $44.9M | 566,000 | 0.67% | 2q | +12.3%+$4.9M |
| RENAISSANCE TECHNOLOGIES LLC | $44.4M | 559,414 | 0.06% | 29q | +83.1%+$20.1M |
| MILLENNIUM MANAGEMENT LLC | $43.3M | 288,872 | 0.02% | 31q | -72.5%-$114.4M |
| Bank of New York Mellon Corp | $43.0M | 542,454 | 0.01% | 31q | +5.4%+$2.2M |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $41.4M | 522,317 | 0.11% | 29q | HELD |
| BOONE CAPITAL MANAGEMENT LLC | $41.2M | 519,977 | 9.64% | 4q | +3.9%+$1.5M |
| NEW YORK STATE COMMON RETIREMENT FUND | $39.6M | 500,050 | 0.05% | 31q | +42.7%+$11.9M |
| NOMURA HOLDINGS INC | $36.6M | 402,192 | 0.04% | 21q | +252.6%+$26.2M |
| BNP PARIBAS FINANCIAL MARKETS | $36.0M | 454,649 | 0.01% | 31q | -5.2%-$2.0M |
| Candriam S.C.A. | $35.3M | 445,019 | 0.16% | 31q | -8.1%-$3.1M |
| FIRST TRUST ADVISORS LP | $33.9M | 427,197 | 0.02% | 5q | -8.8%-$3.3M |
| PINNACLE ASSOCIATES LTD | $33.3M | 419,752 | 0.36% | 31q | -3.8%-$1.3M |
| Corient Private Wealth LP | $31.2M | 393,582 | 0.02% | 15q | +100.2%+$15.6M |
| D. E. Shaw & Co., Inc. | $30.5M | 297,041 | 0.01% | 4q | -30.9%-$13.6M |
| TD Asset Management Inc | $27.0M | 340,548 | 0.02% | 31q | -35.7%-$15.0M |
| Freestone Grove Partners LP | $27.0M | 339,967 | 0.17% | new | NEW |
| Qube Research & Technologies Ltd | $26.5M | 333,952 | 0.02% | 2q | +679.2%+$23.1M |
| Capital Research Global Investors | $26.3M | 331,936 | 0.00% | 2q | +2.8%+$707.3K |
| CAPITAL FUND MANAGEMENT S.A. | $26.1M | 329,554 | 0.12% | 2q | +131.8%+$14.9M |
| ALLIANCEBERNSTEIN L.P. | $25.6M | 340,450 | 0.01% | 31q | -15.0%-$4.5M |
| Carmignac Gestion | $25.5M | 321,000 | 0.33% | new | NEW |
| Privium Fund Management B.V. | $25.4M | 319,924 | 4.66% | 19q | +10.3%+$2.4M |
| Swiss National Bank | $25.0M | 315,000 | 0.01% | 31q | +3.4%+$832.5K |
| Jump Financial, LLC | $24.3M | 306,330 | 0.20% | 2q | +48.2%+$7.9M |
| ARK Investment Management LLC | $23.8M | 300,770 | 0.15% | 31q | +4.2%+$955.8K |
| Integral Health Asset Management, LLC | $23.8M | options only | 0.94% | 2q | OPTIONS |
| Legal & General Group Plc | $23.7M | 299,184 | 0.00% | 31q | +1.5%+$357.2K |
| DAVENPORT & Co LLC | $22.5M | 283,960 | 0.11% | 31q | +19.2%+$3.6M |
| Aberdeen Group plc | $22.0M | 277,400 | 0.03% | 11q | +143.7%+$13.0M |
| California Public Employees Retirement System | $21.5M | 270,843 | 0.01% | 31q | +6.0%+$1.2M |
| CITIGROUP INC | $20.3M | 86,746 | 0.01% | 31q | -40.8%-$14.0M |
| IMC-Chicago, LLC | $20.0M | options only | 0.00% | 4q | OPTIONS |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | $20.0M | 251,215 | 0.26% | 31q | +14.6%+$2.5M |
| RAYMOND JAMES FINANCIAL INC | $18.8M | 237,348 | 0.01% | 7q | +0.9%+$176.6K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $18.5M | 233,499 | 0.03% | 6q | +6.3%+$1.1M |
| WELLS FARGO & COMPANY/MN | $17.9M | 226,213 | 0.00% | 31q | -40.4%-$12.2M |
| BOOTHBAY FUND MANAGEMENT, LLC | $17.7M | 11,808 | 0.23% | 4q | -84.6%-$97.2M |
| Empowered Funds, LLC | $17.7M | 223,142 | 0.09% | 2q | +116.3%+$9.5M |
| Orion Investment Co | $17.5M | 220,335 | 5.10% | 9q | -2.1%-$371.1K |
| Life Cycle Investment Partners Ltd | $17.4M | 219,896 | 0.08% | new | NEW |
| ALGERT GLOBAL LLC | $16.4M | 206,853 | 0.19% | 5q | -11.3%-$2.1M |
| STIFEL FINANCIAL CORP | $16.1M | 202,983 | 0.01% | 31q | +3.2%+$497.9K |
| Eagle Health Investments LP | $15.4M | 194,577 | 2.56% | new | NEW |
| SIG BROKERAGE, LP | $15.1M | options only | 0.29% | 2q | OPTIONS |
| HSBC HOLDINGS PLC | $15.0M | 188,402 | 0.01% | 7q | +1.3%+$194.5K |
| SECTOR GAMMA AS | $15.0M | 189,468 | 3.26% | 31q | +11.8%+$1.6M |
| Polymer Capital Management (HK) LTD | $14.1M | 177,897 | 0.71% | 2q | +190.7%+$9.3M |
Showing the largest 100 of 522 reported holders.
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 491 | $14.3B | 172,058,684 | 62 | 176 | 157 | 4.5% |
| Q1 2026 | 467 | $12.5B | 162,325,267 | 60 | 163 | 138 | 2.3% |
| Q4 2025 | 465 | $12.5B | 155,508,879 | 84 | 151 | 128 | 2.0% |
| Q3 2025 | 416 | $10.1B | 151,123,333 | 114 | 119 | 101 | 2.4% |
| Q2 2025 | 341 | $5.9B | 148,206,675 | 75 | 104 | 98 | 1.6% |
| Q1 2025 | 317 | $4.4B | 145,549,203 | 46 | 89 | 108 | 0.9% |
| Q4 2024 | 328 | $4.9B | 140,129,894 | 39 | 105 | 103 | 1.1% |
| Q3 2024 | 325 | $5.6B | 138,307,949 | 46 | 115 | 93 | 1.1% |
| Q2 2024 | 326 | $6.2B | 126,089,165 | 48 | 98 | 121 | 2.5% |
| Q1 2024 | 322 | $5.6B | 126,381,226 | 44 | 99 | 105 | 1.4% |
| Q4 2023 | 322 | $6.4B | 125,240,824 | 53 | 91 | 95 | 1.0% |
| Q3 2023 | 278 | $5.5B | 119,952,167 | 35 | 82 | 78 | 0.9% |
| Q2 2023 | 267 | $4.6B | 111,654,211 | 31 | 78 | 87 | 0.9% |
| Q1 2023 | 266 | $4.6B | 127,619,521 | 29 | 65 | 102 | 0.5% |
| Q4 2022 | 262 | $3.8B | 100,470,255 | 36 | 81 | 79 | 0.6% |
| Q3 2022 | 350 | $5.6B | 126,548,327 | 52 | 91 | 122 | 0.7% |
| Q2 2022 | 347 | $4.7B | 125,107,161 | 53 | 86 | 123 | 0.7% |
| Q1 2022 | 328 | $4.7B | 125,049,931 | 46 | 101 | 103 | 0.7% |
| Q4 2021 | 336 | $3.8B | 123,749,550 | 42 | 102 | 108 | 1.3% |
| Q3 2021 | 322 | $4.1B | 121,694,202 | 33 | 98 | 98 | 1.5% |
| Q2 2021 | 337 | $5.0B | 124,375,080 | 50 | 110 | 98 | 1.7% |
| Q1 2021 | 365 | $5.6B | 123,476,106 | 49 | 125 | 110 | 1.6% |
| Q4 2020 | 385 | $7.0B | 120,356,244 | 50 | 116 | 102 | 2.2% |
| Q3 2020 | 367 | $5.7B | 118,651,119 | 39 | 106 | 123 | 1.2% |
| Q2 2020 | 375 | $7.2B | 120,404,491 | 49 | 112 | 127 | 1.3% |
| Q1 2020 | 362 | $5.7B | 118,962,179 | 33 | 102 | 133 | 1.4% |
| Q4 2019 | 390 | $7.6B | 122,405,988 | 45 | 110 | 124 | 2.5% |
| Q3 2019 | 372 | $7.5B | 122,382,341 | 42 | 111 | 115 | 2.6% |
| Q2 2019 | 395 | $8.5B | 127,206,854 | 63 | 160 | 90 | 3.7% |
| Q1 2019 | 400 | $9.9B | 117,479,993 | 94 | 99 | 127 | 3.4% |
| Q4 2018 | 328 | $6.6B | 119,314,588 | 2 | 4 | 9 | 2.7% |