EDGEWISE THERAPEUTICS INC (EWTX)
Institutional ownership reported to the SEC as of Q2 2026, across 22 quarters.
218
Reporting holders
$4.8B
Reported value
109.4%
Of shares outstanding
0.5%
Held as options
+12
Holder change
Institutions report 118,840,933 shares against 108,604,129 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | $630.5M | 15,518,492 | 11.68% | 22q | HELD |
| Paradigm Biocapital Advisors LP | $415.1M | 10,215,455 | 7.77% | 10q | +38.7%+$115.8M |
| RA CAPITAL MANAGEMENT, L.P. | $341.0M | 8,392,730 | 2.96% | 10q | -19.5%-$82.7M |
| BlackRock, Inc. | $268.4M | 6,606,336 | 0.00% | 8q | +2.1%+$5.4M |
| Jupiter Topco LLC | $246.9M | 6,075,331 | 0.10% | new | FIRST |
| FMR LLC | $223.0M | 5,489,135 | 0.01% | 22q | +439.7%+$181.7M |
| NOVO HOLDINGS A/S | $217.4M | 5,350,000 | 12.62% | 9q | HELD |
| Driehaus Capital Management LLC | $192.1M | 4,728,623 | 1.11% | 11q | +5.6%+$10.2M |
| PERCEPTIVE ADVISORS LLC | $177.7M | 4,373,974 | 2.67% | 11q | -1.1%-$2.0M |
| VANGUARD CAPITAL MANAGEMENT LLC | $156.9M | 3,860,670 | 0.00% | 2q | +1.9%+$2.9M |
| BAKER BROS. ADVISORS LP | $150.4M | 3,701,719 | 0.75% | 22q | -43.7%-$116.8M |
| Siren, L.L.C. | $129.4M | 3,184,629 | 2.62% | 8q | -28.1%-$50.6M |
| Cormorant Asset Management, LP | $102.0M | 2,510,000 | 5.23% | 22q | -23.0%-$30.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $88.3M | 2,174,051 | 0.00% | 21q | +21.5%+$15.6M |
| Integral Health Asset Management, LLC | $81.3M | 2,000,000 | 3.21% | 8q | +25.0%+$16.3M |
| BRAIDWELL LP | $81.1M | 1,996,965 | 3.00% | 8q | -14.9%-$14.2M |
| MORGAN STANLEY | $79.2M | 1,948,597 | 0.00% | 21q | -13.2%-$12.1M |
| STATE STREET CORP | $74.3M | 1,827,927 | 0.00% | 21q | +6.5%+$4.5M |
| ALLIANCEBERNSTEIN L.P. | $66.7M | 2,119,024 | 0.02% | 16q | +23.0%+$12.5M |
| MPM BIOIMPACT LLC | $65.9M | 1,620,780 | 4.02% | 10q | -2.4%-$1.6M |
| BANK OF AMERICA CORP /DE/ | $63.3M | 1,558,260 | 0.00% | 20q | +17.4%+$9.4M |
| Qube Research & Technologies Ltd | $50.9M | 1,252,507 | 0.05% | 11q | +51.7%+$17.3M |
| DIMENSIONAL FUND ADVISORS LP | $46.3M | 1,139,726 | 0.01% | 16q | -6.6%-$3.3M |
| AMERICAN CENTURY COMPANIES INC | $45.8M | 1,127,078 | 0.02% | 22q | -1.8%-$816.6K |
| First Light Asset Management, LLC | $44.5M | 1,095,171 | 2.70% | 7q | +9.3%+$3.8M |
| VICTORY CAPITAL MANAGEMENT INC | $36.7M | 902,870 | 0.02% | 5q | +14.4%+$4.6M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $32.0M | 786,456 | 0.00% | 2q | +41.1%+$9.3M |
| NORTHERN TRUST CORP | $27.3M | 671,270 | 0.00% | 21q | +16.4%+$3.8M |
| Aberdeen Group plc | $26.3M | 647,926 | 0.04% | 8q | -21.6%-$7.2M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $25.2M | 620,532 | 0.00% | 21q | +4.1%+$984.1K |
| Sixth Street Partners Management Company, L.P. | $25.2M | 620,532 | 0.00% | new | NEW |
| Tyro Capital Management LLC | $24.9M | 612,965 | 5.59% | new | NEW |
| GOLDMAN SACHS GROUP INC | $24.4M | 599,469 | 0.00% | 19q | -4.8%-$1.2M |
| Parkman Healthcare Partners LLC | $23.4M | 577,036 | 2.40% | 16q | +78.7%+$10.3M |
| Artisan Partners Limited Partnership | $23.4M | 574,925 | 0.04% | 8q | -12.8%-$3.4M |
| VANGUARD FIDUCIARY TRUST CO | $22.3M | 548,285 | 0.00% | 2q | +5.1%+$1.1M |
| CITADEL ADVISORS LLC | $21.6M | 469,707 | 0.00% | 22q | +9.5%+$1.9M |
| NORGES BANK | $20.7M | 510,140 | 0.00% | 6q | -32.1%-$9.8M |
| Opaleye Management Inc. | $20.3M | 500,000 | 1.84% | 18q | HELD |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $18.8M | 462,000 | 0.03% | new | NEW |
| Soleus Capital Management, L.P. | $18.3M | 450,889 | 0.63% | 3q | -68.9%-$40.6M |
| Nuveen, LLC | $16.8M | 414,706 | 0.00% | 6q | +23.5%+$3.2M |
| Sofinnova Investments, Inc. | $15.5M | 380,923 | 0.80% | 9q | -1.4%-$226.5K |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $13.6M | 334,014 | 0.02% | 3q | -17.4%-$2.9M |
| RAYMOND JAMES FINANCIAL INC | $12.9M | 317,565 | 0.00% | 5q | +1513.8%+$12.1M |
| Squadron Capital Management LLC | $11.8M | 290,000 | 3.66% | 3q | -17.1%-$2.4M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $11.5M | 283,333 | 0.02% | 7q | HELD |
| DIADEMA PARTNERS LP | $11.1M | 272,214 | 1.40% | 3q | HELD |
| PRUDENTIAL FINANCIAL INC | $10.6M | 260,725 | 0.01% | 2q | +2358.5%+$10.2M |
| KENNEDY CAPITAL MANAGEMENT LLC | $10.4M | 256,608 | 0.18% | 11q | -2.9%-$308.6K |
| Schonfeld Strategic Advisors LLC | $10.4M | 255,202 | 0.04% | 14q | +157.6%+$6.3M |
| DEUTSCHE BANK AG\ | $10.0M | 244,995 | 0.00% | 21q | +10.4%+$939.7K |
| DAFNA Capital Management LLC | $9.2M | 226,819 | 1.76% | 18q | +102.1%+$4.7M |
| Woodline Partners LP | $9.1M | 224,290 | 0.03% | 22q | HELD |
| Bank of New York Mellon Corp | $8.6M | 212,347 | 0.00% | 21q | +10.3%+$809.1K |
| JPMORGAN CHASE & CO | $8.5M | 203,151 | 0.00% | 21q | +37.7%+$2.3M |
| PEREGRINE CAPITAL MANAGEMENT LLC | $8.1M | 198,570 | 0.26% | 2q | -4.8%-$410.4K |
| SEB Asset Management AB | $7.9M | 194,063 | 0.03% | 2q | -6.0%-$505.8K |
| Granahan Investment Management, LLC | $7.9M | 193,778 | 0.28% | 14q | -3.5%-$287.1K |
| NEUBERGER BERMAN GROUP LLC | $7.8M | 191,195 | 0.01% | 6q | +13.3%+$914.9K |
| BARCLAYS PLC | $7.7M | 190,205 | 0.00% | 18q | +7.3%+$526.6K |
| D. E. Shaw & Co., Inc. | $7.7M | 189,115 | 0.00% | 11q | +80.3%+$3.4M |
| UBS Group AG | $7.1M | 174,967 | 0.00% | 10q | -86.7%-$46.2M |
| Caption Management, LLC | $6.5M | options only | 0.03% | 3q | OPTIONS |
| ADAR1 Capital Management, LLC | $5.8M | 143,199 | 0.27% | 6q | +58.1%+$2.1M |
| KVP Capital Advisors, LP | $5.4M | 133,000 | 3.97% | 3q | HELD |
| Point72 Asset Management, L.P. | $5.4M | 117,262 | 0.01% | 2q | HELD |
| Invesco Ltd. | $4.9M | 120,932 | 0.00% | 19q | -12.6%-$709.7K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $4.8M | 118,209 | 0.00% | 11q | +3.0%+$141.8K |
| Quantum Private Wealth, LLC | $4.6M | 113,380 | 1.18% | 19q | -2.8%-$131.8K |
| ALPS ADVISORS INC | $4.4M | 108,795 | 0.02% | 15q | +24.6%+$872.3K |
| Moody Aldrich Partners LLC | $4.3M | 104,952 | 0.77% | 8q | -8.1%-$373.3K |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | $4.1M | options only | 0.42% | new | OPTIONS |
| Artia Global Partners LP | $4.0M | 98,800 | 0.74% | 2q | +50.8%+$1.4M |
| Swiss National Bank | $3.9M | 96,800 | 0.00% | 11q | -6.8%-$288.5K |
| VOYA INVESTMENT MANAGEMENT LLC | $3.8M | 94,671 | 0.00% | 19q | +141.8%+$2.3M |
| HSBC HOLDINGS PLC | $3.7M | 91,638 | 0.00% | new | NEW |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3.7M | 5,692 | 0.00% | 11q | -78.7%-$13.7M |
| HighVista Strategies LLC | $3.7M | 90,996 | 0.84% | 8q | -1.0%-$38.0K |
| RHUMBLINE ADVISERS | $3.7M | 90,232 | 0.00% | 19q | +8.0%+$271.9K |
| Ally Bridge Group (NY) LLC | $3.4M | 83,300 | 2.99% | 3q | -48.3%-$3.2M |
| BOOTHBAY FUND MANAGEMENT, LLC | $3.4M | 82,734 | 0.04% | new | NEW |
| NEW YORK STATE COMMON RETIREMENT FUND | $3.3M | 80,197 | 0.00% | 21q | -9.8%-$355.1K |
| WELLS FARGO & COMPANY/MN | $3.2M | 78,898 | 0.00% | 14q | +56.3%+$1.2M |
| Russell Investments Group, Ltd. | $3.2M | 77,733 | 0.00% | 7q | +1082.4%+$2.9M |
| Centiva Capital, LP | $3.1M | 1,217 | 0.03% | 3q | +125.8%+$1.7M |
| Jefferies Financial Group Inc. | $2.9M | 71,389 | 0.02% | new | NEW |
| Persistent Asset Partners Ltd | $2.8M | 69,441 | 0.84% | 3q | +590.7%+$2.4M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $2.6M | 64,918 | 0.00% | 2q | -3.7%-$101.2K |
| GROUP ONE TRADING LLC | $2.6M | 4,477 | 0.00% | 9q | HELD |
| CITIGROUP INC | $2.4M | 59,563 | 0.00% | 21q | +221.7%+$1.7M |
| TUDOR INVESTMENT CORP ET AL | $2.3M | 56,934 | 0.00% | 9q | +90.5%+$1.1M |
| STATE OF WISCONSIN INVESTMENT BOARD | $2.3M | 56,910 | 0.00% | 10q | +73.0%+$975.7K |
| HighMark Wealth Management LLC | $2.2M | 53,179 | 0.72% | 7q | HELD |
| TWO SIGMA INVESTMENTS, LP | $2.0M | 49,548 | 0.00% | 4q | -2.6%-$52.8K |
| SEI INVESTMENTS CO | $1.9M | 47,543 | 0.00% | 8q | -3.1%-$62.5K |
| ALGERT GLOBAL LLC | $1.9M | 47,240 | 0.02% | 2q | -27.4%-$723.2K |
| XTX Topco Ltd | $1.9M | 45,832 | 0.02% | 3q | +139.9%+$1.1M |
| Legal & General Group Plc | $1.8M | 44,688 | 0.00% | 21q | +5.1%+$87.4K |
| JANE STREET GROUP, LLC | $1.8M | 29,934 | 0.00% | 11q | -15.9%-$340.4K |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | Baker Bros. Advisors LPwith 3 co-filers | 3.4% |
| 2026-08-14 | 13G/A | Paradigm BioCapital Advisors LPwith 3 co-filers | 9.5% |
| 2026-08-14 | 13G/A | RA Capital Management, L.P.with 3 co-filers | 7.8% |
| 2026-08-06 | 13G | FMR LLCwith 1 co-filers | 5.1% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 218 | $4.8B | 118,840,933 | 38 | 79 | 71 | 0.5% |
| Q1 2026 | 206 | $3.8B | 118,871,409 | 33 | 61 | 61 | 0.8% |
| Q4 2025 | 189 | $3.0B | 121,538,675 | 38 | 63 | 52 | 0.8% |
| Q3 2025 | 163 | $1.8B | 111,791,746 | 17 | 49 | 62 | 0.3% |
| Q2 2025 | 167 | $1.6B | 118,658,041 | 23 | 83 | 38 | 0.1% |
| Q1 2025 | 191 | $2.4B | 105,313,857 | 33 | 61 | 59 | 3.8% |
| Q4 2024 | 194 | $2.7B | 98,863,588 | 33 | 63 | 62 | 1.1% |
| Q3 2024 | 172 | $2.8B | 101,284,347 | 52 | 52 | 43 | 2.5% |
| Q2 2024 | 133 | $1.8B | 101,268,444 | 32 | 54 | 27 | 0.1% |
| Q1 2024 | 120 | $1.7B | 92,183,118 | 28 | 56 | 24 | 0.0% |
| Q4 2023 | 109 | $869.9M | 79,493,862 | 33 | 40 | 14 | 0.0% |
| Q3 2023 | 77 | $389.7M | 68,014,616 | 7 | 38 | 15 | 0.0% |
| Q2 2023 | 87 | $535.3M | 69,026,828 | 11 | 37 | 20 | 0.0% |
| Q1 2023 | 74 | $472.5M | 70,863,371 | 9 | 25 | 19 | 0.0% |
| Q4 2022 | 71 | $554.2M | 61,984,167 | 10 | 33 | 10 | 0.0% |
| Q3 2022 | 94 | $648.7M | 65,922,353 | 23 | 36 | 21 | 0.0% |
| Q2 2022 | 77 | $405.7M | 50,965,830 | 16 | 18 | 24 | 0.0% |
| Q1 2022 | 71 | $523.5M | 53,964,536 | 17 | 22 | 17 | 0.0% |
| Q4 2021 | 57 | $769.4M | 50,332,784 | 16 | 25 | 3 | 0.0% |
| Q3 2021 | 47 | $795.8M | 48,038,152 | 4 | 16 | 11 | 0.0% |
| Q2 2021 | 46 | $1.0B | 47,877,175 | 23 | 9 | 5 | 0.0% |
| Q1 2021 | 31 | $1.5B | 45,681,359 | 31 | 0 | 0 | 0.0% |