DESIGN THERAPEUTICS INC (DSGN)
Institutional ownership reported to the SEC as of Q2 2026, across 22 quarters.
136
Reporting holders
$645.4M
Reported value
68.8%
Of shares outstanding
3.5%
Held as options
+13
Holder change
Institutions report 43,030,004 shares against 62,581,651 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| SR One Capital Management, LP | $94.4M | 6,526,476 | 9.09% | 19q | HELD |
| Logos Global Management LP | $43.4M | 3,000,000 | 1.87% | 22q | +53.8%+$15.2M |
| BAKER BROS. ADVISORS LP | $38.8M | 2,678,430 | 0.19% | 22q | +3.6%+$1.3M |
| Driehaus Capital Management LLC | $38.5M | 2,661,115 | 0.22% | 7q | +52.5%+$13.3M |
| BlackRock, Inc. | $38.5M | 2,660,024 | 0.00% | 8q | +24.7%+$7.6M |
| Caption Management, LLC | $37.9M | 1,118,098 | 0.18% | 3q | +1189.5%+$34.9M |
| Point72 Asset Management, L.P. | $34.2M | 2,366,453 | 0.04% | 10q | -13.1%-$5.2M |
| Trails Edge Capital Partners, LP | $29.0M | 2,001,282 | 4.60% | 2q | +134.9%+$16.6M |
| Frazier Life Sciences Management, L.P. | $26.2M | 1,809,854 | 0.57% | new | NEW |
| Vivo Capital, LLC | $23.3M | 1,612,903 | 2.13% | 3q | HELD |
| VANGUARD CAPITAL MANAGEMENT LLC | $22.7M | 1,571,022 | 0.00% | 2q | +16.4%+$3.2M |
| Almitas Capital LLC | $14.9M | 1,026,893 | 3.56% | 11q | -32.9%-$7.3M |
| GEODE CAPITAL MANAGEMENT, LLC | $13.9M | 958,417 | 0.00% | 22q | +38.4%+$3.8M |
| Sofinnova Investments, Inc. | $12.5M | 865,135 | 0.65% | new | NEW |
| FMR LLC | $11.2M | 776,462 | 0.00% | 22q | -2.7%-$317.6K |
| MORGAN STANLEY | $11.1M | 765,425 | 0.00% | 21q | +16.6%+$1.6M |
| STATE STREET CORP | $10.7M | 736,221 | 0.00% | 21q | +11.6%+$1.1M |
| Woodline Partners LP | $10.1M | 700,354 | 0.03% | 6q | -27.2%-$3.8M |
| DIMENSIONAL FUND ADVISORS LP | $10.1M | 694,743 | 0.00% | 17q | +60.9%+$3.8M |
| GOLDMAN SACHS GROUP INC | $9.5M | 656,584 | 0.00% | 22q | +30.1%+$2.2M |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $8.2M | 565,597 | 0.03% | 3q | +95.4%+$4.0M |
| Siren, L.L.C. | $7.6M | 523,212 | 0.15% | new | NEW |
| Qube Research & Technologies Ltd | $6.3M | 437,079 | 0.01% | 2q | +1178.6%+$5.8M |
| RENAISSANCE TECHNOLOGIES LLC | $5.6M | 387,913 | 0.01% | 14q | -5.0%-$293.6K |
| KENNEDY CAPITAL MANAGEMENT LLC | $5.6M | 384,036 | 0.10% | 7q | +41.4%+$1.6M |
| NORTHERN TRUST CORP | $5.1M | 353,197 | 0.00% | 21q | +17.6%+$765.7K |
| ALGERT GLOBAL LLC | $4.3M | 296,085 | 0.05% | 3q | -27.7%-$1.6M |
| ACUTA CAPITAL PARTNERS, LLC | $4.1M | 282,564 | 2.85% | 3q | +93.7%+$2.0M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $3.9M | 271,264 | 0.00% | 21q | +12.3%+$430.9K |
| Sixth Street Partners Management Company, L.P. | $3.9M | 271,264 | 0.00% | new | NEW |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $3.6M | 251,442 | 0.00% | 2q | +81.5%+$1.6M |
| VANGUARD FIDUCIARY TRUST CO | $3.3M | 230,202 | 0.00% | 2q | +17.7%+$499.9K |
| PRUDENTIAL FINANCIAL INC | $3.2M | 224,170 | 0.00% | 13q | +389.3%+$2.6M |
| D. E. Shaw & Co., Inc. | $2.8M | 195,645 | 0.00% | 14q | -58.4%-$4.0M |
| Eversept Partners, LP | $2.7M | 190,000 | 0.14% | new | NEW |
| KVP Capital Advisors, LP | $2.7M | 185,000 | 1.96% | new | NEW |
| J. Goldman & Co LP | $2.6M | 176,770 | 0.07% | new | NEW |
| MILLENNIUM MANAGEMENT LLC | $2.1M | 147,714 | 0.00% | 4q | +35.6%+$561.2K |
| RAYMOND JAMES FINANCIAL INC | $2.0M | 138,521 | 0.00% | 3q | +27.7%+$435.1K |
| Balyasny Asset Management L.P. | $1.6M | 111,103 | 0.00% | new | NEW |
| Elmind Capital, LP | $1.6M | 107,900 | 0.39% | 3q | -48.1%-$1.4M |
| Nuveen, LLC | $1.5M | 104,734 | 0.00% | 6q | -17.4%-$319.5K |
| DAFNA Capital Management LLC | $1.5M | 102,600 | 0.28% | new | NEW |
| CITADEL ADVISORS LLC | $1.4M | 81,971 | 0.00% | 22q | -64.6%-$2.5M |
| Bank of New York Mellon Corp | $1.3M | 92,069 | 0.00% | 21q | +15.6%+$179.8K |
| China Universal Asset Management Co., Ltd. | $1.3M | 89,940 | 0.08% | 7q | +156.2%+$793.4K |
| SummitTX Capital, L.P. | $1.2M | 80,663 | 0.03% | new | NEW |
| AMERICAN CENTURY COMPANIES INC | $1.1M | 76,825 | 0.00% | 9q | +17.0%+$161.9K |
| Palumbo Wealth Management LLC | $1.0M | 71,744 | 0.22% | 10q | HELD |
| AQR CAPITAL MANAGEMENT LLC | $1.0M | 71,114 | 0.00% | 11q | +174.0%+$653.4K |
| AMERIPRISE FINANCIAL INC | $978.1K | 67,598 | 0.00% | 3q | -3.4%-$34.5K |
| Russell Investments Group, Ltd. | $967.4K | 66,859 | 0.00% | 17q | +162.8%+$599.4K |
| ALPS ADVISORS INC | $917.3K | 63,391 | 0.00% | 3q | +26.3%+$190.7K |
| STATE OF WISCONSIN INVESTMENT BOARD | $857.3K | 59,249 | 0.00% | 6q | +20.4%+$145.2K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $805.3K | 15,650 | 0.00% | new | NEW |
| Corient Private Wealth LP | $786.3K | 54,338 | 0.00% | 3q | +100.0%+$393.1K |
| STRS OHIO | $730.7K | 50,500 | 0.00% | 12q | +13.0%+$83.9K |
| Verdad Advisers, LP | $688.1K | 47,557 | 0.66% | 2q | -48.5%-$647.6K |
| BANK OF AMERICA CORP /DE/ | $632.7K | 43,728 | 0.00% | 22q | +88.0%+$296.1K |
| ExodusPoint Capital Management, LP | $597.4K | 41,286 | 0.00% | new | NEW |
| RHUMBLINE ADVISERS | $551.8K | 38,132 | 0.00% | 20q | +9.4%+$47.3K |
| Vanguard Global Advisers, LLC | $514.2K | 35,534 | 0.00% | 2q | +200.1%+$342.9K |
| UBS Group AG | $503.0K | 34,761 | 0.00% | 15q | +103.4%+$255.7K |
| Susquehanna Portfolio Strategies, LLC | $482.9K | 33,375 | 0.01% | new | NEW |
| TWO SIGMA INVESTMENTS, LP | $476.4K | 32,925 | 0.00% | 15q | +102.0%+$240.6K |
| CANADA PENSION PLAN INVESTMENT BOARD | $471.7K | 32,600 | 0.00% | 3q | -46.0%-$402.3K |
| OPPENHEIMER & CO INC | $464.3K | 32,087 | 0.00% | new | NEW |
| ALLIANCEBERNSTEIN L.P. | $460.0K | 43,230 | 0.00% | 17q | -6.3%-$30.7K |
| DEUTSCHE BANK AG\ | $443.0K | 30,613 | 0.00% | 3q | +48.3%+$144.3K |
| Virtus Investment Advisers, LLC | $431.6K | 29,827 | 0.10% | new | NEW |
| Squarepoint Ops LLC | $428.7K | 29,630 | 0.00% | 3q | -65.6%-$817.4K |
| Trexquant Investment LP | $407.3K | 28,150 | 0.00% | 3q | -76.0%-$1.3M |
| WELLS FARGO & COMPANY/MN | $406.2K | 28,072 | 0.00% | 14q | +55.5%+$145.0K |
| GROUP ONE TRADING LLC | $400.8K | options only | 0.00% | 2q | OPTIONS |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $390.7K | 27,000 | 0.01% | 12q | -48.1%-$361.8K |
| Quantinno Capital Management LP | $389.3K | 26,901 | 0.00% | 2q | +90.4%+$184.8K |
| SEI INVESTMENTS CO | $329.1K | 22,740 | 0.00% | 3q | -82.9%-$1.6M |
| XTX Topco Ltd | $323.9K | 22,383 | 0.00% | 4q | -63.3%-$557.9K |
| AlphaCentric Advisors LLC | $311.6K | 21,537 | 0.26% | 3q | +1.4%+$4.4K |
| Invesco Ltd. | $310.1K | 21,429 | 0.00% | 7q | -84.9%-$1.7M |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $299.5K | 20,700 | 0.00% | 3q | +36.2%+$79.7K |
| MetLife Investment Management, LLC | $298.2K | 20,609 | 0.00% | 4q | +35.1%+$77.6K |
| WELLINGTON MANAGEMENT GROUP LLP | $280.7K | 19,400 | 0.00% | new | NEW |
| JPMORGAN CHASE & CO | $240.7K | 16,904 | 0.00% | 21q | +19.6%+$39.4K |
| CITIGROUP INC | $229.8K | 15,880 | 0.00% | 21q | +272.5%+$168.1K |
| Creative Planning | $229.3K | 15,844 | 0.00% | new | NEW |
| NISA INVESTMENT ADVISORS, LLC | $214.5K | 14,824 | 0.00% | 12q | HELD |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $205.1K | 14,171 | 0.00% | 9q | +24.7%+$40.6K |
| Y-Intercept (Hong Kong) Ltd | $186.8K | 12,910 | 0.00% | new | NEW |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $181.6K | 12,553 | 0.00% | new | NEW |
| ROYAL BANK OF CANADA | $178.0K | 12,254 | 0.00% | 21q | +8.1%+$13.3K |
| BARCLAYS PLC | $169.4K | 11,707 | 0.00% | 18q | -79.0%-$637.9K |
| NEW YORK STATE COMMON RETIREMENT FUND | $156.7K | 10,826 | 0.00% | 21q | +434.4%+$127.3K |
| Police & Firemen's Retirement System of New Jersey | $142.5K | 9,849 | 0.00% | 7q | +49.3%+$47.0K |
| BNP PARIBAS FINANCIAL MARKETS | $83.2K | 5,751 | 0.00% | 7q | -88.6%-$644.2K |
| Clearstead Advisors, LLC | $81.2K | 5,610 | 0.00% | 14q | +819.7%+$72.4K |
| Tower Research Capital LLC (TRC) | $71.0K | 4,908 | 0.00% | 22q | +217.7%+$48.7K |
| MERCER GLOBAL ADVISORS INC /ADV | $58.8K | 4,064 | 0.00% | new | NEW |
| Rockefeller Capital Management L.P. | $53.3K | 3,684 | 0.00% | 3q | HELD |
| CAZ INVESTMENTS LP | $50.6K | 3,500 | 0.05% | 9q | HELD |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G | Sirenia Capital Management LPwith 1 co-filers | 9.5% |
| 2026-08-14 | 13G/A | Point72 Asset Management, L.P.with 2 co-filers | 3.8% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 136 | $645.4M | 43,030,004 | 32 | 58 | 32 | 3.5% |
| Q1 2026 | 123 | $397.9M | 37,605,461 | 18 | 51 | 28 | 0.0% |
| Q4 2025 | 112 | $356.5M | 37,681,534 | 28 | 37 | 25 | 1.3% |
| Q3 2025 | 90 | $266.4M | 35,379,016 | 14 | 17 | 35 | 0.0% |
| Q2 2025 | 87 | $114.0M | 33,828,822 | 7 | 31 | 31 | 0.0% |
| Q1 2025 | 89 | $130.2M | 33,713,564 | 13 | 21 | 30 | 0.0% |
| Q4 2024 | 86 | $202.0M | 32,743,603 | 12 | 30 | 18 | 0.0% |
| Q3 2024 | 91 | $168.1M | 31,237,388 | 14 | 25 | 29 | 0.1% |
| Q2 2024 | 86 | $121.6M | 36,299,383 | 11 | 34 | 23 | 0.1% |
| Q1 2024 | 83 | $123.3M | 30,602,024 | 17 | 18 | 31 | 0.0% |
| Q4 2023 | 80 | $83.4M | 31,298,517 | 12 | 32 | 21 | 0.7% |
| Q3 2023 | 81 | $77.4M | 32,599,717 | 13 | 25 | 33 | 0.7% |
| Q2 2023 | 91 | $240.0M | 38,108,238 | 12 | 27 | 37 | 0.0% |
| Q1 2023 | 86 | $191.7M | 33,802,598 | 28 | 20 | 21 | 0.6% |
| Q4 2022 | 70 | $351.2M | 34,135,494 | 19 | 24 | 16 | 1.8% |
| Q3 2022 | 80 | $701.4M | 41,410,313 | 19 | 32 | 18 | 1.3% |
| Q2 2022 | 72 | $544.3M | 38,690,353 | 17 | 25 | 14 | 0.5% |
| Q1 2022 | 63 | $613.7M | 37,990,554 | 5 | 29 | 15 | 0.0% |
| Q4 2021 | 60 | $773.1M | 36,170,206 | 12 | 27 | 5 | 0.0% |
| Q3 2021 | 52 | $414.8M | 28,281,317 | 3 | 20 | 11 | 0.0% |
| Q2 2021 | 50 | $546.2M | 27,839,146 | 18 | 13 | 6 | 0.0% |
| Q1 2021 | 43 | $755.2M | 25,762,953 | 42 | 0 | 0 | 0.0% |