DENALI THERAPEUTICS INC (DNLI)
Institutional ownership reported to the SEC as of Q2 2026, across 31 quarters.
279
Reporting holders
$3.6B
Reported value
86.5%
Of shares outstanding
0.9%
Held as options
+22
Holder change
Institutions report 138,190,761 shares against 159,847,403 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. A figure this high can overstate: where an adviser and a sub-adviser both report the same shares, both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| BlackRock, Inc. | $360.8M | 14,026,413 | 0.01% | 8q | +7.6%+$25.5M |
| BAILLIE GIFFORD & CO | $307.6M | 11,960,230 | 0.28% | 31q | -0.9%-$2.7M |
| STATE STREET CORP | $181.3M | 7,049,304 | 0.01% | 31q | +12.4%+$20.0M |
| Temasek Holdings (Private) Ltd | $180.4M | 7,012,974 | 0.48% | 31q | HELD |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $166.6M | 6,477,057 | 0.01% | 2q | +5.8%+$9.2M |
| VANGUARD CAPITAL MANAGEMENT LLC | $161.4M | 6,275,729 | 0.00% | 2q | +2.1%+$3.3M |
| FMR LLC | $116.7M | 4,535,836 | 0.01% | 31q | -0.9%-$1.0M |
| GOLDMAN SACHS GROUP INC | $106.9M | 4,155,895 | 0.01% | 31q | -5.7%-$6.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $102.2M | 3,973,342 | 0.01% | 31q | +6.6%+$6.3M |
| Holocene Advisors, LP | $100.4M | 3,905,225 | 0.23% | 5q | +22.2%+$18.3M |
| BAKER BROS. ADVISORS LP | $96.0M | 3,734,336 | 0.48% | 26q | HELD |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $81.3M | 3,161,972 | 0.01% | 31q | -28.7%-$32.7M |
| UBS Group AG | $80.3M | 3,120,592 | 0.01% | 31q | +21.4%+$14.1M |
| DIMENSIONAL FUND ADVISORS LP | $73.6M | 2,860,604 | 0.01% | 29q | +6.3%+$4.3M |
| NORGES BANK | $72.7M | 2,824,746 | 0.01% | 28q | -44.8%-$59.0M |
| Pictet Asset Management Holding SA | $71.9M | 2,791,206 | 0.07% | 12q | +9.1%+$6.0M |
| Capital Research Global Investors | $66.0M | 2,565,817 | 0.01% | 16q | +2.0%+$1.3M |
| Fisher Asset Management, LLC | $62.1M | 2,414,162 | 0.02% | 10q | -0.9%-$584.7K |
| ALLIANCEBERNSTEIN L.P. | $57.3M | 2,984,807 | 0.02% | 31q | +3.2%+$1.8M |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $56.8M | 2,208,263 | 0.09% | 3q | +1828.2%+$53.9M |
| Casdin Capital, LLC | $52.6M | 2,045,000 | 2.63% | 31q | +11.1%+$5.3M |
| Crestline Management, L.P. | $49.1M | 1,910,732 | 91.90% | 31q | -13.6%-$7.7M |
| PRINCIPAL FINANCIAL GROUP INC | $36.5M | 1,420,083 | 0.02% | 31q | -4.0%-$1.5M |
| Foresite Capital Management VI LLC | $35.9M | 1,396,771 | 5.59% | 4q | +15.4%+$4.8M |
| Siren, L.L.C. | $35.9M | 1,396,513 | 0.73% | 8q | HELD |
| NORTHERN TRUST CORP | $35.7M | 1,389,765 | 0.00% | 31q | +6.0%+$2.0M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $34.9M | 1,355,514 | 0.03% | 5q | +357.2%+$27.2M |
| Aberdeen Group plc | $34.6M | 1,345,481 | 0.05% | 11q | -27.4%-$13.1M |
| Cercano Management LLC | $32.1M | 1,250,000 | 1.80% | 15q | +100.0%+$16.1M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $32.0M | 1,244,955 | 0.00% | 31q | +3.1%+$965.9K |
| Sixth Street Partners Management Company, L.P. | $32.0M | 1,244,955 | 0.00% | new | NEW |
| BANK OF AMERICA CORP /DE/ | $31.7M | 1,230,957 | 0.00% | 31q | +8.5%+$2.5M |
| Artisan Partners Limited Partnership | $31.5M | 1,224,497 | 0.05% | 2q | +11.3%+$3.2M |
| Candriam S.C.A. | $30.6M | 1,189,886 | 0.14% | 21q | +8.2%+$2.3M |
| MILLENNIUM MANAGEMENT LLC | $29.0M | 1,125,748 | 0.01% | 10q | -10.5%-$3.4M |
| ADAR1 Capital Management, LLC | $26.5M | 1,029,080 | 1.21% | 10q | -45.0%-$21.7M |
| VANGUARD FIDUCIARY TRUST CO | $25.5M | 991,904 | 0.01% | 2q | +4.4%+$1.1M |
| MORGAN STANLEY | $24.7M | 961,050 | 0.00% | 35q | -13.0%-$3.7M |
| Bank of New York Mellon Corp | $20.6M | 800,283 | 0.00% | 31q | +4.2%+$829.3K |
| DAFNA Capital Management LLC | $19.0M | 739,014 | 3.62% | 6q | +132.0%+$10.8M |
| AMERICAN CENTURY COMPANIES INC | $18.3M | 712,526 | 0.01% | 30q | -23.9%-$5.7M |
| Nuveen, LLC | $15.7M | 608,967 | 0.00% | 6q | +106.0%+$8.1M |
| CITADEL ADVISORS LLC | $15.4M | 66,971 | 0.00% | 30q | -63.1%-$26.4M |
| Ensign Peak Advisors, Inc | $15.0M | 582,669 | 0.02% | 27q | -43.5%-$11.5M |
| MARSHALL WACE, LLP | $14.1M | 549,830 | 0.01% | 11q | -44.5%-$11.4M |
| SEGALL BRYANT & HAMILL, LLC | $13.4M | 519,483 | 0.16% | 7q | +1.8%+$229.9K |
| CITIGROUP INC | $12.5M | 487,278 | 0.00% | 31q | +1140.6%+$11.5M |
| Balyasny Asset Management L.P. | $11.1M | options only | 0.01% | 2q | OPTIONS |
| Defilade Capital Management, L.P. | $10.1M | 391,866 | 1.35% | 3q | -71.2%-$24.9M |
| AQR CAPITAL MANAGEMENT LLC | $10.0M | 388,469 | 0.00% | 5q | +278.7%+$7.4M |
| Woodline Partners LP | $9.4M | 364,082 | 0.03% | 7q | HELD |
| Invesco Ltd. | $8.8M | 343,898 | 0.00% | 31q | +10.9%+$866.8K |
| ExodusPoint Capital Management, LP | $8.7M | 336,567 | 0.06% | new | NEW |
| Marex Group Ltd | $7.6M | 295,631 | 0.03% | 5q | +3.0%+$222.0K |
| JPMORGAN CHASE & CO | $7.6M | 287,019 | 0.00% | 31q | -11.4%-$978.0K |
| Swiss National Bank | $7.0M | 270,500 | 0.00% | 31q | -1.2%-$84.9K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6.5M | 123,258 | 0.00% | 29q | +144.2%+$3.9M |
| TD Asset Management Inc | $6.0M | 231,644 | 0.01% | 31q | -9.4%-$620.4K |
| GROUPAMA ASSET MANAGMENT | $5.9M | 229,939 | 0.07% | 11q | +11.0%+$586.6K |
| Privium Fund Management B.V. | $5.9M | 229,857 | 1.09% | 2q | -9.8%-$643.0K |
| XTX Topco Ltd | $5.8M | 226,953 | 0.08% | 2q | +188.9%+$3.8M |
| Alyeska Investment Group, L.P. | $5.6M | 219,334 | 0.01% | 3q | -88.7%-$44.3M |
| Susquehanna Portfolio Strategies, LLC | $5.4M | 211,474 | 0.09% | 3q | +33.9%+$1.4M |
| MASTERS CAPITAL MANAGEMENT LLC | $5.1M | 200,000 | 0.13% | 5q | -66.7%-$10.3M |
| Burkehill Global Management, LP | $5.1M | 200,000 | 0.19% | 3q | HELD |
| SCS Capital Management LLC | $5.1M | 197,998 | 0.05% | 6q | HELD |
| RHUMBLINE ADVISERS | $5.0M | 194,787 | 0.00% | 31q | +5.7%+$271.1K |
| WELLS FARGO & COMPANY/MN | $4.9M | 189,865 | 0.00% | 31q | -11.8%-$654.5K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $4.6M | 179,195 | 0.01% | 6q | +80.1%+$2.0M |
| Rhenman & Partners Asset Management AB | $4.6M | 179,000 | 0.43% | 6q | -10.1%-$514.4K |
| NEW YORK STATE COMMON RETIREMENT FUND | $4.4M | 171,712 | 0.01% | 31q | +34.0%+$1.1M |
| EDMOND DE ROTHSCHILD HOLDING S.A. | $4.2M | 165,080 | 0.06% | 23q | -26.9%-$1.6M |
| ALPS ADVISORS INC | $4.1M | 160,378 | 0.02% | 17q | +24.2%+$804.3K |
| E. Ohman J:or Asset Management AB | $4.1M | 160,000 | 0.10% | new | NEW |
| DEUTSCHE BANK AG\ | $3.9M | 149,804 | 0.00% | 34q | +24.5%+$757.1K |
| GREAT LAKES ADVISORS, LLC | $3.7M | 145,045 | 0.03% | 2q | -36.1%-$2.1M |
| VANGUARD ASSET MANAGEMENT, Ltd | $3.6M | 141,153 | 0.00% | 2q | +12.7%+$409.2K |
| Man Group plc | $3.6M | 139,065 | 0.01% | 3q | HELD |
| Hudson Bay Capital Management LP | $3.3M | 130,000 | 0.01% | 11q | -62.5%-$5.6M |
| Odyssean, LLC | $3.2M | 125,062 | 0.52% | new | NEW |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3.0M | 117,348 | 0.00% | 31q | -6.5%-$208.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $3.0M | 115,775 | 0.01% | 31q | +3.7%+$105.0K |
| B. Metzler seel. Sohn & Co. AG | $2.9M | 112,300 | 0.02% | 3q | HELD |
| Legal & General Group Plc | $2.9M | 111,953 | 0.00% | 31q | +1.5%+$43.8K |
| Integrated Wealth Concepts LLC | $2.6M | 102,241 | 0.01% | 5q | +2.7%+$69.1K |
| PFM Health Sciences, LP | $2.6M | 100,966 | 0.22% | new | NEW |
| Integral Health Asset Management, LLC | $2.6M | 100,000 | 0.10% | new | NEW |
| Ghisallo Capital Management LLC | $2.6M | 100,000 | 0.05% | 3q | HELD |
| Lumbard & Kellner, LLC | $2.5M | 98,282 | 0.77% | 2q | +3.7%+$90.0K |
| Rafferty Asset Management, LLC | $2.5M | 96,342 | 0.01% | 25q | -36.1%-$1.4M |
| D.A. DAVIDSON & CO. | $2.3M | 87,741 | 0.01% | 3q | -20.4%-$578.5K |
| Russell Investments Group, Ltd. | $2.2M | 86,032 | 0.00% | 31q | +512.0%+$1.9M |
| MetLife Investment Management, LLC | $2.2M | 85,621 | 0.01% | 32q | +10.4%+$207.4K |
| BARCLAYS PLC | $2.2M | 84,892 | 0.00% | 30q | +63.0%+$843.8K |
| STATE OF WISCONSIN INVESTMENT BOARD | $2.2M | 84,652 | 0.00% | 31q | +2.8%+$59.0K |
| Creative Planning | $2.2M | 84,644 | 0.00% | 20q | +14.3%+$272.0K |
| AMERIPRISE FINANCIAL INC | $2.1M | 82,650 | 0.00% | 5q | -53.8%-$2.5M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $2.0M | 78,937 | 0.00% | 9q | -17.1%-$418.5K |
| Phocas Financial Corp. | $1.8M | 71,197 | 0.25% | new | NEW |
| Knights of Columbus Asset Advisors LLC | $1.7M | 67,591 | 0.09% | 13q | +20.0%+$289.7K |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-04 | 13G/A | BAILLIE GIFFORD & CO | 7.5% |
| 2026-07-08 | 13G/A | T. Rowe Price Investment Management, Inc. | 10.2% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 279 | $3.6B | 138,190,761 | 51 | 110 | 69 | 0.9% |
| Q1 2026 | 257 | $2.6B | 137,168,788 | 49 | 101 | 50 | 0.7% |
| Q4 2025 | 231 | $2.3B | 139,685,704 | 39 | 79 | 62 | 0.1% |
| Q3 2025 | 221 | $1.8B | 125,838,563 | 32 | 83 | 61 | 0.2% |
| Q2 2025 | 212 | $1.8B | 127,795,181 | 42 | 77 | 57 | 0.1% |
| Q1 2025 | 205 | $1.8B | 131,112,582 | 32 | 68 | 74 | 0.1% |
| Q4 2024 | 208 | $2.5B | 122,128,776 | 29 | 75 | 56 | 0.1% |
| Q3 2024 | 196 | $3.5B | 121,582,320 | 31 | 71 | 58 | 0.1% |
| Q2 2024 | 187 | $2.8B | 119,681,789 | 30 | 72 | 53 | 0.3% |
| Q1 2024 | 189 | $2.5B | 120,424,922 | 33 | 68 | 63 | 0.2% |
| Q4 2023 | 183 | $2.4B | 112,007,851 | 25 | 66 | 56 | 0.1% |
| Q3 2023 | 168 | $2.1B | 102,945,245 | 24 | 60 | 48 | 0.1% |
| Q2 2023 | 177 | $3.0B | 101,800,101 | 25 | 74 | 45 | 0.1% |
| Q1 2023 | 165 | $2.4B | 101,861,093 | 22 | 75 | 37 | 0.5% |
| Q4 2022 | 161 | $2.6B | 94,666,498 | 23 | 67 | 41 | 0.1% |
| Q3 2022 | 196 | $2.8B | 92,697,391 | 31 | 74 | 51 | 0.1% |
| Q2 2022 | 180 | $2.7B | 92,937,617 | 24 | 64 | 54 | 0.1% |
| Q1 2022 | 182 | $2.8B | 86,970,714 | 16 | 64 | 59 | 0.1% |
| Q4 2021 | 209 | $3.8B | 85,515,875 | 22 | 84 | 54 | 0.5% |
| Q3 2021 | 213 | $4.3B | 84,833,663 | 31 | 77 | 60 | 0.4% |
| Q2 2021 | 212 | $6.4B | 80,820,505 | 34 | 77 | 61 | 0.6% |
| Q1 2021 | 218 | $4.6B | 80,493,073 | 41 | 77 | 67 | 0.4% |
| Q4 2020 | 207 | $6.2B | 88,663,036 | 56 | 58 | 67 | 0.8% |
| Q3 2020 | 172 | $3.0B | 82,763,712 | 43 | 48 | 48 | 0.2% |
| Q2 2020 | 145 | $2.0B | 83,008,438 | 31 | 52 | 35 | 0.1% |
| Q1 2020 | 128 | $1.4B | 80,660,466 | 32 | 51 | 20 | 0.1% |
| Q4 2019 | 110 | $1.3B | 71,727,936 | 13 | 29 | 36 | 0.2% |
| Q3 2019 | 115 | $1.1B | 72,258,941 | 17 | 38 | 23 | 0.2% |
| Q2 2019 | 115 | $1.5B | 71,607,515 | 23 | 41 | 21 | 0.3% |
| Q1 2019 | 115 | $1.6B | 69,078,671 | 33 | 31 | 26 | 0.0% |
| Q4 2018 | 90 | $1.4B | 68,827,291 | 0 | 1 | 2 | 0.0% |