DEFINIUM THERAPEUTICS INC (DFTX)
Institutional ownership reported to the SEC as of Q2 2026, across 3 quarters.
356
Reporting holders
$5.4B
Reported value
82.4%
Of shares outstanding
4.6%
Held as options
+115
Holder change
Institutions report 110,683,414 shares against 134,366,950 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| BlackRock, Inc. | $528.4M | 11,232,834 | 0.01% | 2q | +32.5%+$129.5M |
| Avoro Capital Advisors LLC | $338.2M | 7,188,888 | 3.04% | 2q | +43.8%+$103.0M |
| Driehaus Capital Management LLC | $322.0M | 6,845,276 | 1.87% | 3q | +15.8%+$43.9M |
| Jupiter Topco LLC | $264.0M | 5,615,645 | 0.11% | new | FIRST |
| Capital World Investors | $252.5M | 5,367,723 | 0.03% | new | NEW |
| FMR LLC | $223.6M | 4,752,921 | 0.01% | 2q | +162.6%+$138.5M |
| GEODE CAPITAL MANAGEMENT, LLC | $171.5M | 3,644,813 | 0.01% | 2q | +46.1%+$54.1M |
| STATE STREET CORP | $144.2M | 3,065,390 | 0.00% | 2q | +24.0%+$27.9M |
| Capital International Investors | $139.4M | 2,963,410 | 0.03% | new | NEW |
| Octagon Capital Advisors LP | $138.8M | 2,950,000 | 12.47% | 2q | +20.9%+$24.0M |
| WELLINGTON MANAGEMENT GROUP LLP | $138.8M | 2,949,734 | 0.02% | 2q | +126.1%+$77.4M |
| Deep Track Capital, LP | $129.4M | 2,750,000 | 1.88% | 2q | -8.3%-$11.8M |
| CITADEL ADVISORS LLC | $106.4M | 1,688,587 | 0.01% | 2q | +26.6%+$22.4M |
| Commodore Capital LP | $94.1M | 2,000,000 | 5.60% | 2q | HELD |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $89.3M | 40,954 | 0.01% | 2q | -49.7%-$88.3M |
| GOLDMAN SACHS GROUP INC | $84.7M | 1,800,852 | 0.01% | 2q | +7.5%+$5.9M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $77.5M | 1,648,426 | 0.00% | 2q | +88.9%+$36.5M |
| RA CAPITAL MANAGEMENT, L.P. | $70.6M | 1,500,000 | 0.61% | new | NEW |
| VANGUARD CAPITAL MANAGEMENT LLC | $69.9M | 1,486,454 | 0.00% | 2q | +35.5%+$18.3M |
| Siren, L.L.C. | $66.8M | 1,419,493 | 1.35% | 2q | +54.4%+$23.5M |
| MARSHALL WACE, LLP | $61.1M | 1,298,946 | 0.05% | 3q | +8.2%+$4.6M |
| NORTHERN TRUST CORP | $55.0M | 1,169,238 | 0.01% | 2q | +46.3%+$17.4M |
| AMERIPRISE FINANCIAL INC | $54.0M | 1,148,363 | 0.01% | 2q | -40.6%-$36.9M |
| Nuveen, LLC | $52.0M | 1,105,314 | 0.01% | 2q | +58.3%+$19.2M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $51.0M | 1,083,576 | 0.01% | 2q | +34.0%+$12.9M |
| Sixth Street Partners Management Company, L.P. | $51.0M | 1,083,576 | 0.01% | new | NEW |
| Woodline Partners LP | $47.2M | 1,003,641 | 0.15% | 2q | +33.3%+$11.8M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $47.0M | 1,000,000 | 0.07% | 2q | -13.0%-$7.1M |
| Boxer Capital Management, LLC | $47.0M | 998,500 | 3.54% | 2q | +66.8%+$18.8M |
| TWO SIGMA INVESTMENTS, LP | $43.4M | 921,818 | 0.03% | 2q | -23.3%-$13.2M |
| Balyasny Asset Management L.P. | $42.2M | 897,658 | 0.05% | 2q | -29.6%-$17.7M |
| VANGUARD FIDUCIARY TRUST CO | $38.9M | 827,693 | 0.01% | 2q | +43.7%+$11.8M |
| Holocene Advisors, LP | $37.5M | 796,574 | 0.08% | 2q | -27.1%-$13.9M |
| AWM Investment Company, Inc. | $36.9M | 784,800 | 3.20% | 3q | -27.1%-$13.7M |
| Bank of New York Mellon Corp | $36.6M | 777,271 | 0.01% | 2q | +3.2%+$1.1M |
| Polar Capital Holdings Plc | $36.6M | 777,253 | 0.09% | new | NEW |
| JANE STREET GROUP, LLC | $35.4M | options only | 0.00% | 2q | OPTIONS |
| ALLIANCEBERNSTEIN L.P. | $34.1M | 1,803,287 | 0.01% | 2q | +1866.4%+$32.3M |
| EVENTIDE ASSET MANAGEMENT, LLC | $33.4M | 710,000 | 0.45% | 2q | +3.5%+$1.1M |
| NEUBERGER BERMAN GROUP LLC | $32.3M | 687,539 | 0.02% | 2q | +415.5%+$26.1M |
| Qube Research & Technologies Ltd | $32.1M | 682,901 | 0.03% | 2q | +60.3%+$12.1M |
| Candriam S.C.A. | $28.9M | 614,425 | 0.13% | 2q | -52.5%-$31.9M |
| ArrowMark Colorado Holdings LLC | $26.5M | 564,069 | 1.10% | 2q | -64.6%-$48.5M |
| Catalio Capital Management, LP | $26.5M | 562,672 | 4.97% | 2q | -45.8%-$22.4M |
| Blackstone Inc. | $26.4M | 561,612 | 0.08% | 2q | +10.4%+$2.5M |
| Integral Health Asset Management, LLC | $25.9M | 550,000 | 1.02% | 2q | +37.5%+$7.1M |
| BAMCO INC /NY/ | $24.5M | 520,108 | 0.04% | new | NEW |
| UBS Group AG | $23.5M | 499,467 | 0.00% | 2q | +1.1%+$258.2K |
| FRANKLIN RESOURCES INC | $22.9M | 486,219 | 0.00% | new | NEW |
| Point72 Asset Management, L.P. | $22.8M | 483,980 | 0.03% | 2q | +175.8%+$14.5M |
| Ensign Peak Advisors, Inc | $21.9M | 466,106 | 0.04% | 3q | -57.4%-$29.5M |
| MORGAN STANLEY | $21.4M | 454,912 | 0.00% | 2q | +3.7%+$768.6K |
| GREAT POINT PARTNERS LLC | $20.0M | 425,000 | 3.78% | new | NEW |
| Caption Management, LLC | $19.6M | 45,000 | 0.09% | 2q | +33.3%+$4.9M |
| RTW INVESTMENTS, LP | $18.8M | 400,000 | 0.16% | 2q | +33.3%+$4.7M |
| Cormorant Asset Management, LP | $18.8M | 400,000 | 0.96% | new | NEW |
| SILVERARC CAPITAL MANAGEMENT, LLC | $18.8M | 400,000 | 1.96% | new | NEW |
| Ally Bridge Group (NY) LLC | $18.8M | options only | 16.64% | new | OPTIONS |
| ASSETMARK, INC | $18.7M | 396,542 | 0.03% | new | NEW |
| GROUP ONE TRADING LLC | $18.0M | 63,943 | 0.03% | 2q | -27.2%-$6.7M |
| MILLENNIUM MANAGEMENT LLC | $17.7M | 266,076 | 0.01% | 2q | -68.6%-$38.6M |
| ORBIMED ADVISORS LLC | $17.2M | 365,400 | 0.32% | 2q | -54.6%-$20.6M |
| D. E. Shaw & Co., Inc. | $14.8M | 315,410 | 0.01% | 2q | +16.1%+$2.1M |
| SILVERBACK ASSET MANAGEMENT LLC | $13.8M | options only | 1.50% | 2q | OPTIONS |
| Tetragon Partners GP Ltd | $13.5M | 286,990 | 2.13% | 2q | +43.5%+$4.1M |
| JPMORGAN CHASE & CO | $12.4M | 265,955 | 0.00% | 2q | +0.5%+$65.6K |
| Sofinnova Investments, Inc. | $12.0M | 255,903 | 0.62% | 2q | -25.6%-$4.2M |
| PFM Health Sciences, LP | $11.7M | 249,020 | 1.01% | 2q | +21.3%+$2.1M |
| HighVista Strategies LLC | $11.4M | 242,884 | 2.60% | 2q | +30.7%+$2.7M |
| Trexquant Investment LP | $11.0M | 233,199 | 0.06% | new | NEW |
| SEVEN GRAND MANAGERS, LLC | $10.6M | 225,000 | 0.43% | 2q | HELD |
| Swiss National Bank | $10.4M | 221,200 | 0.01% | 2q | +39.6%+$3.0M |
| Eversept Partners, LP | $10.2M | 217,185 | 0.53% | 2q | +35.1%+$2.7M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $9.9M | 211,183 | 0.00% | 2q | +8651.9%+$9.8M |
| TD Asset Management Inc | $9.9M | 209,460 | 0.01% | new | NEW |
| ROYCE & ASSOCIATES LP | $9.8M | 208,551 | 0.08% | 2q | -10.9%-$1.2M |
| SEB Asset Management AB | $9.8M | 208,254 | 0.04% | new | NEW |
| SIMPLEX TRADING, LLC | $8.9M | 47,651 | 0.01% | 2q | +15.8%+$1.2M |
| SUPERSTRING CAPITAL MANAGEMENT LP | $8.9M | 188,282 | 5.59% | 2q | -46.4%-$7.7M |
| EMERALD ADVISERS, LLC | $8.4M | 178,751 | 0.20% | new | NEW |
| Aberdeen Group plc | $8.2M | 175,000 | 0.01% | new | NEW |
| BANK OF AMERICA CORP /DE/ | $7.7M | 164,575 | 0.00% | 2q | +3.9%+$293.1K |
| Tri Locum Partners LP | $7.7M | 162,996 | 0.94% | 2q | -55.9%-$9.7M |
| RHUMBLINE ADVISERS | $7.4M | 158,096 | 0.01% | 2q | +31.8%+$1.8M |
| Brevan Howard Capital Management LP | $7.4M | 156,812 | 0.05% | 2q | -25.9%-$2.6M |
| Russell Investments Group, Ltd. | $7.2M | 153,477 | 0.01% | 2q | +28.5%+$1.6M |
| LMR Partners LLP | $7.1M | 150,200 | 0.03% | new | NEW |
| Seven Fleet Capital Management LP | $7.0M | 148,647 | 1.15% | 2q | +48.8%+$2.3M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $6.9M | 146,368 | 0.01% | 2q | +454.3%+$5.6M |
| Rock Springs Capital Management LP | $6.7M | 143,187 | 0.33% | new | NEW |
| DEUTSCHE BANK AG\ | $6.7M | 142,947 | 0.00% | 2q | -65.3%-$12.6M |
| SummitTX Capital, L.P. | $6.7M | 142,489 | 0.17% | new | NEW |
| STEMPOINT CAPITAL LP | $6.5M | 137,124 | 1.11% | 2q | -78.9%-$24.2M |
| AQR CAPITAL MANAGEMENT LLC | $6.3M | 134,152 | 0.00% | 2q | +135.0%+$3.6M |
| BIT Capital GmbH | $6.0M | 128,131 | 0.18% | 2q | -53.8%-$7.0M |
| FRED ALGER MANAGEMENT, LLC | $5.9M | 125,256 | 0.02% | 2q | +35.9%+$1.6M |
| WELLS FARGO & COMPANY/MN | $5.7M | 122,033 | 0.00% | 2q | +52.6%+$2.0M |
| Atika Capital Management LLC | $5.7M | 122,000 | 0.38% | new | NEW |
| AdvisorShares Investments LLC | $5.7M | 121,381 | 0.69% | 2q | +32.9%+$1.4M |
| EMERALD MUTUAL FUND ADVISERS TRUST | $5.7M | 121,249 | 0.20% | new | NEW |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | DRIEHAUS CAPITAL MANAGEMENT LLC | 5.4% |
| 2026-08-14 | 13G/A | Commodore Capital LPwith 3 co-filers | 1.8% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 356 | $5.4B | 110,683,414 | 144 | 108 | 63 | 4.6% |
| Q1 2026 | 241 | $1.5B | 79,706,341 | 232 | 1 | 4 | 2.6% |
| Q4 2025 | 7 | $153.5M | 11,462,308 | 6 | 0 | 0 | 0.0% |