| FMR LLC | $192.1M | 5,835,259 | 0.01% | new | NEW |
| NOVO HOLDINGS A/S | $127.8M | 3,883,289 | 7.42% | new | NEW |
| SR One Capital Management, LP | $108.9M | 3,308,649 | 10.48% | new | NEW |
| PERCEPTIVE ADVISORS LLC | $88.1M | 2,675,296 | 1.32% | new | NEW |
| MONTANOVA CAPITAL, LLC | $82.4M | 2,503,109 | 1.51% | new | NEW |
| NVP ASSOCIATES, LLC | $74.7M | 2,268,404 | 22.75% | new | NEW |
| WELLINGTON MANAGEMENT GROUP LLP | $72.5M | 2,201,986 | 0.01% | new | NEW |
| Catalio Capital Management, LP | $55.2M | 1,675,830 | 10.37% | new | NEW |
| EVENTIDE ASSET MANAGEMENT, LLC | $45.3M | 1,375,486 | 0.61% | new | NEW |
| Bellevue Group AG | $44.4M | 1,350,000 | 0.94% | new | NEW |
| BlackRock, Inc. | $32.2M | 977,264 | 0.00% | new | NEW |
| Pivotal bioVenture Partners Investment Advisor LLC | $31.8M | 966,792 | 10.34% | new | NEW |
| CITADEL ADVISORS LLC | $31.6M | 959,098 | 0.00% | new | NEW |
| ANDERA PARTNERS | $30.6M | 929,824 | 14.82% | new | NEW |
| JENNISON ASSOCIATES LLC | $26.8M | 812,749 | 0.02% | new | NEW |
| BRAIDWELL LP | $26.4M | 801,395 | 0.98% | new | NEW |
| TPG GP A, LLC | $25.4M | 773,069 | 0.51% | new | NEW |
| VANGUARD CAPITAL MANAGEMENT LLC | $24.4M | 739,770 | 0.00% | new | NEW |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $24.1M | 731,000 | 0.25% | new | NEW |
| Rock Springs Capital Management LP | $21.8M | 662,918 | 1.07% | new | NEW |
| GEODE CAPITAL MANAGEMENT, LLC | $14.3M | 434,650 | 0.00% | new | NEW |
| Soleus Capital Management, L.P. | $13.8M | 419,000 | 0.48% | new | NEW |
| INFINITUM ASSET MANAGEMENT, LLC | $13.5M | 411,378 | 1.38% | new | NEW |
| BAKER BROS. ADVISORS LP | $11.5M | 350,000 | 0.06% | new | NEW |
| FRANKLIN RESOURCES INC | $10.9M | 331,684 | 0.00% | new | NEW |
| SILVERARC CAPITAL MANAGEMENT, LLC | $10.9M | 330,487 | 1.13% | new | NEW |
| GOLDMAN SACHS GROUP INC | $9.3M | 283,854 | 0.00% | new | NEW |
| FEDERATED HERMES, INC. | $5.3M | 160,000 | 0.01% | new | NEW |
| Woodline Partners LP | $5.0M | 150,999 | 0.02% | new | NEW |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $4.8M | 146,992 | 0.00% | new | NEW |
| Sixth Street Partners Management Company, L.P. | $4.8M | 146,992 | 0.00% | new | NEW |
| ADAR1 Capital Management, LLC | $4.8M | 146,447 | 0.22% | new | NEW |
| NORTHERN TRUST CORP | $4.5M | 136,394 | 0.00% | new | NEW |
| STEMPOINT CAPITAL LP | $3.9M | 118,000 | 0.67% | new | NEW |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $3.9M | 117,338 | 0.00% | new | NEW |
| VANGUARD FIDUCIARY TRUST CO | $3.8M | 116,763 | 0.00% | new | NEW |
| ACUTA CAPITAL PARTNERS, LLC | $3.8M | 115,000 | 2.64% | new | NEW |
| Burkehill Global Management, LP | $3.8M | 115,000 | 0.14% | new | NEW |
| MOORE CAPITAL MANAGEMENT, LP | $3.6M | 110,451 | 0.05% | new | NEW |
| Blackstone Inc. | $3.2M | 97,985 | 0.01% | new | NEW |
| TD Asset Management Inc | $3.1M | 94,636 | 0.00% | new | NEW |
| SEVEN GRAND MANAGERS, LLC | $2.5M | 75,000 | 0.10% | new | NEW |
| Ghisallo Capital Management LLC | $2.3M | 70,000 | 0.05% | new | NEW |
| Atom Investors LP | $2.2M | 68,254 | 0.20% | new | NEW |
| Aberdeen Group plc | $2.2M | 67,174 | 0.00% | new | NEW |
| Zimmer Partners, LP | $2.1M | 62,500 | 0.05% | new | NEW |
| Avidity Partners Management LP | $2.0M | 60,000 | 0.32% | new | NEW |
| LMR Partners LLP | $1.8M | 54,323 | 0.01% | new | NEW |
| AMERIPRISE FINANCIAL INC | $1.6M | 50,045 | 0.00% | new | NEW |
| Freestone Grove Partners LP | $1.6M | 50,000 | 0.01% | new | NEW |
| Brevan Howard Capital Management LP | $1.4M | 43,001 | 0.01% | new | NEW |
| Bank of New York Mellon Corp | $1.3M | 40,140 | 0.00% | new | NEW |
| Shay Capital LLC | $1.3M | 40,000 | 0.08% | new | NEW |
| Balyasny Asset Management L.P. | $1.1M | 33,975 | 0.00% | new | NEW |
| Nuveen, LLC | $976.7K | 29,670 | 0.00% | new | NEW |
| D. E. Shaw & Co., Inc. | $757.2K | 23,000 | 0.00% | new | NEW |
| Davidson Kempner Capital Management LP | $757.2K | 23,000 | 0.01% | new | NEW |
| RHUMBLINE ADVISERS | $674.9K | 20,502 | 0.00% | new | NEW |
| DEUTSCHE BANK AG\ | $557.4K | 16,933 | 0.00% | new | NEW |
| MORGAN STANLEY | $556.5K | 16,906 | 0.00% | new | NEW |
| WELLS FARGO & COMPANY/MN | $501.3K | 15,228 | 0.00% | new | NEW |
| Hudson Bay Capital Management LP | $466.8K | 14,180 | 0.00% | new | NEW |
| Longaeva Partners L.P. | $411.5K | 12,500 | 0.01% | new | NEW |
| UBS Group AG | $404.8K | 12,296 | 0.00% | new | NEW |
| BANK OF AMERICA CORP /DE/ | $384.1K | 11,668 | 0.00% | new | NEW |
| Invesco Ltd. | $382.1K | 11,607 | 0.00% | new | NEW |
| RAYMOND JAMES FINANCIAL INC | $378.0K | 11,483 | 0.00% | new | NEW |
| XTX Topco Ltd | $350.3K | 10,640 | 0.00% | new | NEW |
| MetLife Investment Management, LLC | $339.3K | 10,308 | 0.00% | new | NEW |
| SOROS FUND MANAGEMENT LLC | $329.2K | 10,000 | 0.00% | new | NEW |
| CITIGROUP INC | $264.5K | 8,035 | 0.00% | new | NEW |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $258.6K | 7,854 | 0.00% | new | NEW |
| Vanguard Global Advisers, LLC | $246.4K | 7,485 | 0.00% | new | NEW |
| JPMORGAN CHASE & CO | $220.2K | 7,102 | 0.00% | new | NEW |
| TWO SIGMA INVESTMENTS, LP | $219.7K | 6,675 | 0.00% | new | NEW |
| SEI INVESTMENTS CO | $217.0K | 6,592 | 0.00% | new | NEW |
| NEW YORK STATE COMMON RETIREMENT FUND | $197.5K | 6,000 | 0.00% | new | NEW |
| Police & Firemen's Retirement System of New Jersey | $166.3K | 5,052 | 0.00% | new | NEW |
| BARCLAYS PLC | $144.5K | 4,390 | 0.00% | new | NEW |
| BNP PARIBAS FINANCIAL MARKETS | $130.3K | 3,958 | 0.00% | new | NEW |
| Legal & General Group Plc | $115.3K | 3,504 | 0.00% | new | NEW |
| STRS OHIO | $111.9K | 3,400 | 0.00% | new | NEW |
| Persistent Asset Partners Ltd | $67.9K | 2,064 | 0.02% | new | NEW |
| PRICE T ROWE ASSOCIATES INC /MD/ | $57.1K | 1,735,231 | 0.01% | new | NEW |
| T. Rowe Price Investment Management, Inc. | $52.8K | 1,602,745 | 0.03% | new | NEW |
| Ameritas Investment Partners, Inc. | $51.2K | 1,555 | 0.00% | new | NEW |
| Russell Investments Group, Ltd. | $45.1K | 1,369 | 0.00% | new | NEW |
| Tower Research Capital LLC (TRC) | $34.7K | 1,055 | 0.00% | new | NEW |
| ROYAL BANK OF CANADA | $19.0K | 588 | 0.00% | new | NEW |
| NISA INVESTMENT ADVISORS, LLC | $16.6K | 503 | 0.00% | new | NEW |
| Sterling Capital Management LLC | $4.9K | 149 | 0.00% | new | NEW |
| MERCER GLOBAL ADVISORS INC /ADV | $3.8K | 116 | 0.00% | new | NEW |
| Virtu Financial LLC | $289 | 8,792 | 0.01% | new | NEW |