APPLIED THERAPEUTICS INC (APLT)
Institutional ownership reported to the SEC as of Q4 2025, across 27 quarters.
50
Reporting holders
$3.8M
Reported value
1.9%
Held as options
-18
Holder change
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| VANGUARD GROUP INC | $635.3K | 6,353,018 | 0.00% | 26q | +24.5%+$125.0K |
| Knoll Capital Management, LLC | $605.0K | 6,050,000 | 0.28% | 27q | -22.4%-$175.0K |
| DELTEC ASSET MANAGEMENT LLC | $384.7K | 3,847,449 | 0.06% | new | NEW |
| BlackRock, Inc. | $325.1K | 3,251,462 | 0.00% | 6q | -15.4%-$59.2K |
| Pathstone Holdings, LLC | $305.1K | 2,643,540 | 0.00% | 3q | HELD |
| RENAISSANCE TECHNOLOGIES LLC | $270.6K | 2,706,156 | 0.00% | new | NEW |
| JANE STREET GROUP, LLC | $208.7K | 2,087,404 | 0.00% | 3q | HELD |
| GEODE CAPITAL MANAGEMENT, LLC | $149.3K | 1,492,903 | 0.00% | 26q | +16.8%+$21.5K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $121.2K | 1,211,629 | 0.00% | 8q | -45.2%-$100.0K |
| MILLENNIUM MANAGEMENT LLC | $105.2K | 1,051,846 | 0.00% | 9q | -44.8%-$85.5K |
| UBS Group AG | $71.9K | 718,924 | 0.00% | 27q | -62.3%-$118.7K |
| DEUTSCHE BANK AG\ | $62.2K | 622,226 | 0.00% | 8q | HELD |
| Graham Capital Management, L.P. | $57.3K | 572,759 | 0.00% | new | NEW |
| STATE STREET CORP | $55.8K | 558,178 | 0.00% | 26q | +7.6%+$4.0K |
| EQUITEC PROPRIETARY MARKETS, LLC | $55.3K | 300,600 | 0.03% | new | NEW |
| Lynx1 Capital Management LP | $41.0K | 410,500 | 0.01% | new | NEW |
| MARSHALL WACE, LLP | $33.7K | 337,389 | 0.00% | 6q | -86.7%-$220.5K |
| Hennion & Walsh Asset Management, Inc. | $32.7K | 327,137 | 0.00% | 7q | +15.7%+$4.4K |
| Bank of New York Mellon Corp | $25.4K | 253,573 | 0.00% | 7q | +219.3%+$17.4K |
| NORTHERN TRUST CORP | $24.5K | 245,144 | 0.00% | 27q | +41.1%+$7.1K |
| Rockefeller Capital Management L.P. | $24.2K | 241,897 | 0.00% | 2q | -38.3%-$15.0K |
| GTS SECURITIES LLC | $20.0K | 200,009 | 0.00% | new | NEW |
| CITADEL ADVISORS LLC | $19.3K | options only | 0.00% | 11q | OPTIONS |
| MORGAN STANLEY | $17.8K | 178,474 | 0.00% | 26q | -75.0%-$53.5K |
| GROUP ONE TRADING LLC | $17.4K | 48,675 | 0.00% | 10q | -35.3%-$9.5K |
| CreativeOne Wealth, LLC | $17.0K | 169,974 | 0.00% | 5q | +70.0%+$7.0K |
| CITIGROUP INC | $16.3K | 163,449 | 0.00% | 10q | +2289.3%+$15.7K |
| GOLDMAN SACHS GROUP INC | $14.6K | 146,219 | 0.00% | 9q | -5.8% |
| SIMPLEX TRADING, LLC | $13.6K | options only | 0.00% | 14q | OPTIONS |
| TUDOR INVESTMENT CORP ET AL | $5.7K | 57,454 | 0.00% | 5q | HELD |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $5.3K | 52,692 | 0.00% | 10q | -89.0%-$42.4K |
| SPHERA FUNDS MANAGEMENT LTD. | $5.0K | 50,000 | 0.00% | 8q | HELD |
| Adams Wealth Management | $3.9K | 38,637 | 0.00% | 5q | HELD |
| CacheTech Inc. | $3.9K | 38,637 | 0.00% | 5q | HELD |
| T. Rowe Price Investment Management, Inc. | $3.0K | 30,092,327 | 0.00% | 6q | +40.6% |
| DIADEMA PARTNERS LP | $2.0K | options only | 0.00% | 2q | OPTIONS |
| Tower Research Capital LLC (TRC) | $2.0K | 19,675 | 0.00% | 6q | -42.7%-$1.5K |
| Cresset Asset Management, LLC | $1.7K | 17,091 | 0.00% | 2q | HELD |
| Point72 Asset Management, L.P. | $1.7K | 17,020 | 0.00% | new | NEW |
| AQR CAPITAL MANAGEMENT LLC | $1.3K | 13,413 | 0.00% | 4q | -87.8%-$9.6K |
| JPMORGAN CHASE & CO | $1.2K | 12,064 | 0.00% | 12q | -21.0% |
| Perennial Investment Advisors, LLC | $1.2K | 11,600 | 0.00% | 14q | HELD |
| AlphaQuest LLC | $466 | 4,661 | 0.00% | 5q | HELD |
| BANK OF AMERICA CORP /DE/ | $311 | 3,109 | 0.00% | 13q | -73.4% |
| BNP PARIBAS FINANCIAL MARKETS | $297 | 2,974 | 0.00% | 26q | -14.4% |
| SBI Securities Co., Ltd. | $79 | 788 | 0.00% | 5q | -4.3% |
| RHUMBLINE ADVISERS | $54 | 544 | 0.00% | 11q | HELD |
| Virtu Financial LLC | $50 | 496,288 | 0.00% | 2q | +872.8% |
| Optiver Holding B.V. | $43 | 427 | 0.00% | new | NEW |
| FMR LLC | $18 | 184 | 0.00% | 7q | -98.9%-$1.7K |
| Federation des caisses Desjardins du Quebec | $8 | 84 | 0.00% | 24q | HELD |
| Roble, Belko & Company, Inc | $7 | 65,571 | 0.00% | 3q | +112.6% |
| SG Americas Securities, LLC | $4 | 41,748 | 0.00% | 7q | +154.5% |
| Persistent Asset Partners Ltd | $1 | options only | 0.00% | 2q | OPTIONS |
Five percent filings
Anyone crossing 5% of a company must say so within days - far sooner than the next quarterly holdings report. A 13D declares an intent to influence the company; a 13G is the passive version. See all activist filings →
| Filed | Form | Filer | % of class |
|---|---|---|---|
| 2026-08-14 | 13G/A | Venrock Healthcare Capital Partners III, L.P.with 6 co-filers | 0.0% |
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q4 2025 | 50 | $3.8M | 36,531,588 | 8 | 8 | 18 | 1.9% |
| Q3 2025 | 68 | $44.7M | 73,172,161 | 13 | 12 | 24 | 1.1% |
| Q2 2025 | 69 | $21.7M | 69,258,275 | 11 | 12 | 28 | 0.6% |
| Q1 2025 | 87 | $47.0M | 95,629,770 | 10 | 24 | 31 | 0.4% |
| Q4 2024 | 112 | $95.8M | 109,218,334 | 29 | 40 | 25 | 2.3% |
| Q3 2024 | 128 | $983.9M | 111,524,042 | 47 | 31 | 29 | 3.4% |
| Q2 2024 | 95 | $489.1M | 103,848,786 | 26 | 29 | 24 | 1.0% |
| Q1 2024 | 86 | $725.6M | 100,154,840 | 26 | 34 | 16 | 6.2% |
| Q4 2023 | 81 | $230.5M | 60,797,771 | 27 | 25 | 11 | 11.7% |
| Q3 2023 | 53 | $125.6M | 42,529,548 | 21 | 12 | 7 | 15.7% |
| Q2 2023 | 38 | $49.0M | 30,756,137 | 7 | 12 | 9 | 19.7% |
| Q1 2023 | 31 | $21.1M | 21,778,921 | 6 | 9 | 7 | 16.3% |
| Q4 2022 | 32 | $14.2M | 18,446,189 | 6 | 3 | 13 | 0.2% |
| Q3 2022 | 41 | $25.2M | 22,671,560 | 5 | 13 | 12 | 16.4% |
| Q2 2022 | 46 | $25.4M | 26,708,067 | 8 | 14 | 16 | 0.1% |
| Q1 2022 | 69 | $26.1M | 12,349,369 | 14 | 19 | 19 | 0.3% |
| Q4 2021 | 67 | $136.3M | 15,004,497 | 11 | 26 | 13 | 1.5% |
| Q3 2021 | 70 | $253.8M | 15,109,136 | 8 | 21 | 18 | 1.1% |
| Q2 2021 | 68 | $321.3M | 15,367,672 | 10 | 28 | 12 | 0.6% |
| Q1 2021 | 68 | $278.9M | 14,854,343 | 8 | 36 | 14 | 0.1% |
| Q4 2020 | 71 | $279.2M | 12,147,613 | 16 | 24 | 16 | 4.2% |
| Q3 2020 | 65 | $253.7M | 12,194,892 | 10 | 21 | 17 | 0.2% |
| Q2 2020 | 73 | $422.0M | 11,792,839 | 21 | 43 | 6 | 0.0% |
| Q1 2020 | 63 | $315.4M | 9,648,363 | 25 | 24 | 11 | 0.0% |
| Q4 2019 | 45 | $138.0M | 5,059,492 | 17 | 25 | 2 | 0.0% |
| Q3 2019 | 30 | $26.3M | 2,395,851 | 20 | 3 | 3 | 0.0% |
| Q2 2019 | 13 | $18.1M | 2,196,176 | 13 | 0 | 0 | 0.0% |