AMYLYX PHARMACEUTICALS INC (AMLX)
Institutional ownership reported to the SEC as of Q2 2026, across 18 quarters.
202
Reporting holders
$2.1B
Reported value
103.7%
Of shares outstanding
0.7%
Held as options
+31
Holder change
Institutions report 115,580,492 shares against 111,423,048 outstanding. Shares only - option lines are excluded, which is why this can be compared with the company at all. The count comes from the cover page of the company's own most recent report, so it is dated when that was filed rather than at quarter end. Over 100% because an adviser and a sub-adviser can both report the same shares, and both are counted.
Options share is the part of reported value carried in derivative lines rather than shares. A high figure means institutions are expressing a view on this security without owning much of it.
Holders
| Filer | Value | Shares | Their book | Held | Change |
|---|---|---|---|---|---|
| FMR LLC | $300.4M | 16,727,909 | 0.01% | 18q | +0.6%+$1.7M |
| BlackRock, Inc. | $158.5M | 8,827,085 | 0.00% | 8q | HELD |
| PERCEPTIVE ADVISORS LLC | $149.7M | 8,334,882 | 2.25% | 8q | +0.6%+$898.0K |
| TCG Crossover Management, LLC | $112.1M | 6,243,812 | 2.70% | 8q | HELD |
| Commodore Capital LP | $101.5M | 5,650,000 | 6.04% | 4q | HELD |
| Jupiter Topco LLC | $94.0M | 5,236,102 | 0.04% | new | FIRST |
| Saturn V Capital Management LP | $83.0M | 4,624,101 | 11.91% | 7q | +6.3%+$4.9M |
| VANGUARD CAPITAL MANAGEMENT LLC | $75.9M | 4,224,224 | 0.00% | 2q | +2.0%+$1.5M |
| MORGAN STANLEY | $56.2M | 3,130,808 | 0.00% | 18q | +43.9%+$17.2M |
| Driehaus Capital Management LLC | $54.5M | 3,036,970 | 0.32% | 5q | +1.7%+$894.8K |
| First Light Asset Management, LLC | $54.3M | 3,023,256 | 3.30% | 4q | -5.2%-$3.0M |
| FRANKLIN RESOURCES INC | $53.0M | 2,950,225 | 0.01% | 3q | +30.5%+$12.4M |
| GOLDMAN SACHS GROUP INC | $51.3M | 2,858,239 | 0.00% | 16q | +8.8%+$4.2M |
| STATE STREET CORP | $46.8M | 2,603,337 | 0.00% | 18q | +10.2%+$4.3M |
| GEODE CAPITAL MANAGEMENT, LLC | $41.9M | 2,335,315 | 0.00% | 18q | +5.6%+$2.2M |
| JPMORGAN CHASE & CO | $34.9M | 1,863,650 | 0.00% | 18q | +1067.2%+$31.9M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $34.1M | 1,900,000 | 0.05% | 6q | -46.6%-$29.8M |
| Siren, L.L.C. | $26.6M | 1,480,586 | 0.54% | 2q | +20.4%+$4.5M |
| 683 Capital Management, LLC | $24.7M | 1,279,512 | 1.21% | 9q | -16.4%-$4.8M |
| EVENTIDE ASSET MANAGEMENT, LLC | $23.8M | 1,327,536 | 0.32% | 4q | -12.3%-$3.3M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $19.1M | 1,061,534 | 0.00% | 2q | +12.4%+$2.1M |
| Alyeska Investment Group, L.P. | $18.9M | 1,053,015 | 0.05% | new | NEW |
| Almitas Capital LLC | $17.5M | 974,881 | 4.20% | 9q | -54.1%-$20.6M |
| Nantahala Capital Management, LLC | $17.5M | 973,368 | 0.29% | 8q | +81.7%+$7.9M |
| DIMENSIONAL FUND ADVISORS LP | $16.2M | 902,463 | 0.00% | 7q | HELD |
| Jones Hill Capital LP | $16.1M | 894,058 | 3.41% | 2q | -44.1%-$12.7M |
| Woodline Partners LP | $15.2M | 846,387 | 0.05% | 6q | HELD |
| NORTHERN TRUST CORP | $14.9M | 831,740 | 0.00% | 18q | +6.6%+$930.9K |
| BANK OF AMERICA CORP /DE/ | $14.8M | 821,841 | 0.00% | 18q | -38.2%-$9.1M |
| Boxer Capital Management, LLC | $14.4M | 800,000 | 1.08% | 7q | HELD |
| Aberdeen Group plc | $13.2M | 737,670 | 0.02% | new | NEW |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $13.0M | 725,030 | 0.00% | 18q | +1.2%+$158.1K |
| Sixth Street Partners Management Company, L.P. | $13.0M | 725,030 | 0.00% | new | NEW |
| Connor, Clark & Lunn Investment Management Ltd. | $12.9M | 721,002 | 0.02% | 12q | -17.0%-$2.6M |
| GREAT POINT PARTNERS LLC | $12.6M | 700,000 | 2.38% | 6q | -60.0%-$18.9M |
| Balyasny Asset Management L.P. | $12.3M | 684,974 | 0.02% | 4q | -38.1%-$7.6M |
| Qube Research & Technologies Ltd | $12.2M | 681,389 | 0.01% | 14q | -3.0%-$374.4K |
| VANGUARD FIDUCIARY TRUST CO | $11.2M | 623,078 | 0.00% | 2q | +6.3%+$663.2K |
| TWO SIGMA INVESTMENTS, LP | $10.7M | 593,435 | 0.01% | 11q | +266.4%+$7.7M |
| DEUTSCHE BANK AG\ | $10.0M | 557,937 | 0.00% | 18q | -56.0%-$12.7M |
| ADAR1 Capital Management, LLC | $9.6M | 494,378 | 0.44% | 11q | -50.6%-$9.8M |
| Rock Springs Capital Management LP | $9.0M | 499,764 | 0.44% | 6q | HELD |
| FEDERATED HERMES, INC. | $8.3M | 462,205 | 0.01% | 16q | +27.1%+$1.8M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8.0M | 10,339 | 0.00% | 18q | -74.0%-$22.9M |
| Nearwater Capital Markets, Ltd | $7.6M | 425,000 | 0.13% | new | NEW |
| Parkman Healthcare Partners LLC | $7.2M | 398,782 | 0.73% | 5q | -35.8%-$4.0M |
| HighVista Strategies LLC | $6.9M | 386,080 | 1.58% | 3q | +9.7%+$610.6K |
| STEMPOINT CAPITAL LP | $6.9M | 384,304 | 1.19% | 4q | -71.3%-$17.2M |
| JANE STREET GROUP, LLC | $6.8M | 299,565 | 0.00% | 15q | HELD |
| Logos Global Management LP | $6.3M | 350,000 | 0.27% | 4q | -50.0%-$6.3M |
| Trexquant Investment LP | $6.3M | 349,439 | 0.04% | new | NEW |
| Nuveen, LLC | $5.9M | 330,521 | 0.00% | 5q | +24.8%+$1.2M |
| Tetragon Partners GP Ltd | $5.5M | 297,926 | 0.87% | 5q | -6.3%-$368.5K |
| Ensign Peak Advisors, Inc | $5.5M | 305,441 | 0.01% | new | NEW |
| JUPITER ASSET MANAGEMENT LTD | $4.9M | 274,944 | 0.02% | 3q | -53.6%-$5.7M |
| Bank of New York Mellon Corp | $4.9M | 274,435 | 0.00% | 5q | +9.3%+$419.0K |
| UBS Group AG | $4.9M | 271,881 | 0.00% | 18q | -16.2%-$941.8K |
| FIRST TRUST ADVISORS LP | $4.6M | 254,587 | 0.00% | new | NEW |
| SummitTX Capital, L.P. | $4.1M | 227,690 | 0.11% | 4q | HELD |
| WELLINGTON MANAGEMENT GROUP LLP | $3.8M | 212,842 | 0.00% | 7q | -11.9%-$515.6K |
| Cormorant Asset Management, LP | $3.6M | 200,000 | 0.18% | 4q | -42.9%-$2.7M |
| Aldebaran Capital, LLC | $3.5M | 195,892 | 2.64% | 9q | -1.0%-$35.9K |
| Walleye Capital LLC | $3.5M | 186,588 | 0.01% | 4q | +202.4%+$2.3M |
| CITADEL ADVISORS LLC | $3.4M | 178,686 | 0.00% | 18q | -56.6%-$4.4M |
| ORBIMED ADVISORS LLC | $3.3M | 183,400 | 0.06% | new | NEW |
| D. E. Shaw & Co., Inc. | $3.1M | 174,285 | 0.00% | 16q | +134.8%+$1.8M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $3.1M | 173,407 | 0.00% | 3q | +10.4%+$293.1K |
| ACUTA CAPITAL PARTNERS, LLC | $3.0M | 168,115 | 2.10% | 4q | +11.3%+$306.2K |
| NORGES BANK | $2.9M | 159,900 | 0.00% | new | NEW |
| Alpha Wave Global, LP | $2.8M | 155,422 | 0.04% | 8q | +9.2%+$235.0K |
| Swiss National Bank | $2.6M | 144,200 | 0.00% | 3q | +10.7%+$249.6K |
| PFM Health Sciences, LP | $2.6M | 143,700 | 0.22% | 6q | -1.1%-$28.3K |
| Invesco Ltd. | $2.5M | 139,942 | 0.00% | 6q | -18.5%-$568.9K |
| WELLS FARGO & COMPANY/MN | $2.3M | 128,164 | 0.00% | 18q | -14.7%-$395.2K |
| AMERIPRISE FINANCIAL INC | $2.3M | 125,484 | 0.00% | new | NEW |
| Lighthouse Investment Partners, LLC | $2.2M | 122,909 | 0.06% | new | NEW |
| Corient Private Wealth LP | $2.1M | 118,644 | 0.00% | new | NEW |
| Ikarian Capital, LLC | $2.1M | 117,500 | 0.23% | new | NEW |
| RHUMBLINE ADVISERS | $2.0M | 112,920 | 0.00% | 5q | +4.1%+$80.0K |
| ALPS ADVISORS INC | $2.0M | 112,447 | 0.01% | 3q | +25.0%+$403.5K |
| Elmind Capital, LP | $2.0M | 112,000 | 0.51% | 3q | HELD |
| Campbell & CO Investment Adviser LLC | $1.8M | 100,963 | 0.10% | 4q | +85.5%+$835.9K |
| Affinity Asset Advisors, LLC | $1.8M | 98,999 | 0.08% | new | NEW |
| SIMPLEX TRADING, LLC | $1.7M | options only | 0.00% | 18q | OPTIONS |
| Russell Investments Group, Ltd. | $1.6M | 87,574 | 0.00% | 14q | +47.6%+$507.0K |
| Quantinno Capital Management LP | $1.5M | 80,850 | 0.00% | new | NEW |
| ALLIANCEBERNSTEIN L.P. | $1.5M | 104,400 | 0.00% | 5q | +29.2%+$328.0K |
| 1492 Capital Management LLC | $1.4M | 79,751 | 0.42% | new | NEW |
| CITIGROUP INC | $1.2M | 68,684 | 0.00% | 18q | +116.1%+$662.8K |
| Schonfeld Strategic Advisors LLC | $1.2M | 66,804 | 0.00% | 9q | -14.1%-$197.4K |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.1M | 61,278 | 0.00% | 4q | -15.0%-$193.7K |
| Moody Aldrich Partners LLC | $1.0M | 57,802 | 0.19% | new | NEW |
| VANGUARD ASSET MANAGEMENT, Ltd | $1.0M | 56,948 | 0.00% | 2q | +31.6%+$245.4K |
| Legal & General Group Plc | $1.0M | 56,477 | 0.00% | 5q | +1.3%+$12.6K |
| BARCLAYS PLC | $1.0M | 56,258 | 0.00% | 18q | -94.2%-$16.4M |
| MetLife Investment Management, LLC | $1.0M | 55,700 | 0.00% | 5q | +8.0%+$73.9K |
| Hudson Bay Capital Management LP | $898.0K | 50,000 | 0.00% | new | NEW |
| Vanguard Global Advisers, LLC | $859.4K | 47,851 | 0.00% | 2q | HELD |
| FOX RUN MANAGEMENT, L.L.C. | $804.9K | 44,817 | 0.13% | new | NEW |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $760.6K | 42,351 | 0.00% | 5q | HELD |
Showing the largest 100 of 209 reported holders.
Quarter by quarter
Coverage begins with the quarter ending 2018-12-31. Earlier filings exist only as occasional late amendments, too sparse to describe a market, so they are not shown.
| Quarter | Holders | Value | Shares | New | Added | Trimmed | Options |
|---|---|---|---|---|---|---|---|
| Q2 2026 | 202 | $2.1B | 115,580,492 | 47 | 64 | 55 | 0.7% |
| Q1 2026 | 171 | $1.6B | 114,472,277 | 18 | 59 | 49 | 0.7% |
| Q4 2025 | 173 | $1.4B | 111,889,750 | 34 | 65 | 41 | 0.5% |
| Q3 2025 | 167 | $1.5B | 110,145,564 | 57 | 38 | 47 | 0.6% |
| Q2 2025 | 126 | $520.1M | 80,915,402 | 29 | 34 | 37 | 0.3% |
| Q1 2025 | 128 | $260.7M | 73,413,961 | 29 | 47 | 27 | 0.4% |
| Q4 2024 | 116 | $189.0M | 49,201,438 | 24 | 34 | 37 | 1.6% |
| Q3 2024 | 106 | $137.5M | 41,627,237 | 22 | 29 | 31 | 2.2% |
| Q2 2024 | 114 | $83.5M | 42,117,544 | 27 | 27 | 42 | 4.2% |
| Q1 2024 | 139 | $176.4M | 52,144,383 | 26 | 51 | 42 | 15.7% |
| Q4 2023 | 167 | $1.0B | 62,304,315 | 31 | 67 | 38 | 9.8% |
| Q3 2023 | 157 | $1.1B | 58,713,993 | 34 | 60 | 41 | 5.7% |
| Q2 2023 | 139 | $1.2B | 51,415,067 | 26 | 56 | 35 | 6.6% |
| Q1 2023 | 128 | $1.4B | 47,529,139 | 32 | 52 | 31 | 5.5% |
| Q4 2022 | 110 | $1.7B | 44,714,318 | 33 | 41 | 28 | 3.4% |
| Q3 2022 | 101 | $1.2B | 37,732,125 | 33 | 37 | 24 | 12.8% |
| Q2 2022 | 79 | $549.8M | 26,621,963 | 24 | 34 | 13 | 6.7% |
| Q1 2022 | 72 | $306.2M | 23,421,051 | 74 | 0 | 0 | 2.1% |