# SKYE BIOSCIENCE INC (SKYE)

> Institutional ownership reported to the SEC as of Q2 2026, from Form 13F filings. Source: https://holderbook.com/stocks/SKYE/

- Reporting holders: 45
- Reported value: $11.4M
- Shares held by institutions: 16,100,098 of 35,421,413 outstanding
- Held through calls: 1.2%
- Held through puts: 0.5%

A 13F reports long US equity positions only. Shorts, bonds, foreign listings and cash are not visible here, and positions are disclosed up to 45 days after the quarter ends.

## Largest holders

| Manager | Value | Shares | Share of their book | Quarters held |
|---|---|---|---|---|
| [5AM Venture Management, LLC](https://holderbook.com/funds/1799883-5am-venture-management-llc/) | $6.7M | 9,681,763 | 2.3% | 9 |
| [Versant Venture Management, LLC](https://holderbook.com/funds/1560009-versant-venture-management-llc/) | $1.4M | 2,007,704 | 0.9% | 10 |
| [BAKER BROS. ADVISORS LP](https://holderbook.com/funds/1263508-baker-bros-advisors-lp/) | $1.1M | 1,575,243 | 0.0% | 9 |
| [VANGUARD CAPITAL MANAGEMENT LLC](https://holderbook.com/funds/2100119-vanguard-capital-management-llc/) | $529.4K | 763,882 | 0.0% | 2 |
| [SPHERA FUNDS MANAGEMENT LTD.](https://holderbook.com/funds/1496201-sphera-funds-management-ltd/) | $470.7K | 678,928 | 0.1% | 9 |
| [CITADEL ADVISORS LLC](https://holderbook.com/funds/1423053-citadel-advisors-llc/) | $171.9K | 0 | 0.0% | 5 |
| [PLATINUM INVESTMENT MANAGEMENT LTD](https://holderbook.com/funds/1256071-platinum-investment-management-ltd/) | $161.6K | 233,095 | 0.0% | 8 |
| [BlackRock, Inc.](https://holderbook.com/funds/2012383-blackrock-inc/) | $161.5K | 232,874 | 0.0% | 8 |
| [GEODE CAPITAL MANAGEMENT, LLC](https://holderbook.com/funds/1214717-geode-capital-management-llc/) | $151.2K | 218,055 | 0.0% | 9 |
| [MILLENNIUM MANAGEMENT LLC](https://holderbook.com/funds/1273087-millennium-management-llc/) | $137.6K | 198,524 | 0.0% | 5 |
| [STATE STREET CORP](https://holderbook.com/funds/93751-state-street-corp/) | $102.4K | 147,660 | 0.0% | 9 |
| [VANGUARD FIDUCIARY TRUST CO](https://holderbook.com/funds/933478-vanguard-fiduciary-trust-co/) | $72.2K | 104,229 | 0.0% | 2 |
| [UBS Group AG](https://holderbook.com/funds/1610520-ubs-group-ag/) | $51.1K | 73,800 | 0.0% | 9 |
| [NORTHERN TRUST CORP](https://holderbook.com/funds/73124-northern-trust-corp/) | $39.1K | 56,327 | 0.0% | 9 |
| [Qube Research & Technologies Ltd](https://holderbook.com/funds/1729829-qube-research-technologies-ltd/) | $29.9K | 43,082 | 0.0% | 1 |
| [GROUP ONE TRADING LLC](https://holderbook.com/funds/932540-group-one-trading-llc/) | $21.9K | 4,589 | 0.0% | 1 |
| [SIMPLEX TRADING, LLC](https://holderbook.com/funds/1488542-simplex-trading-llc/) | $20.2K | 26,976 | 0.0% | 1 |
| [XTX Topco Ltd](https://holderbook.com/funds/1828301-xtx-topco-ltd/) | $14.6K | 20,993 | 0.0% | 3 |
| [Engineers Gate Manager LP](https://holderbook.com/funds/1620220-engineers-gate-manager-lp/) | $14.0K | 20,194 | 0.0% | 3 |
| [Vanguard Global Advisers, LLC](https://holderbook.com/funds/1811242-vanguard-global-advisers-llc/) | $3.2K | 4,557 | 0.0% | 2 |
| [MERCER GLOBAL ADVISORS INC /ADV](https://holderbook.com/funds/853758-mercer-global-advisors-inc-adv/) | $2.1K | 3,065 | 0.0% | 1 |
| [MORGAN STANLEY](https://holderbook.com/funds/895421-morgan-stanley/) | $1.7K | 2,469 | 0.0% | 9 |
| [BARCLAYS PLC](https://holderbook.com/funds/312069-barclays-plc/) | $455 | 655 | 0.0% | 3 |
| [OSAIC HOLDINGS, INC.](https://holderbook.com/funds/1677044-osaic-holdings-inc/) | $413 | 600 | 0.0% | 8 |
| [NATIONAL BANK OF CANADA /FI/](https://holderbook.com/funds/926171-national-bank-of-canada-fi/) | $275 | 400 | 0.0% | 3 |

## Quarter by quarter

| Quarter | Holders | Reported value |
|---|---|---|
| Q2 2026 | 45 | $11.4M |
| Q1 2026 | 40 | $10.0M |
| Q4 2025 | 50 | $12.2M |
| Q3 2025 | 59 | $83.6M |
| Q2 2025 | 59 | $85.8M |
| Q1 2025 | 72 | $39.4M |
| Q4 2024 | 71 | $71.3M |
| Q3 2024 | 74 | $100.8M |
| Q2 2024 | 62 | $206.8M |
| Q1 2024 | 3 | $31.4M |
| Q4 2023 | 1 | $4.4K |
| Q2 2023 | 1 | $253 |