# APPLIED THERAPEUTICS INC (APLT)

> Institutional ownership reported to the SEC as of Q4 2025, from Form 13F filings. Source: https://holderbook.com/stocks/APLT/

- Reporting holders: 54
- Reported value: $6.8M
- Held through calls: 0.5%
- Held through puts: 0.6%

A 13F reports long US equity positions only. Shorts, bonds, foreign listings and cash are not visible here, and positions are disclosed up to 45 days after the quarter ends.

## Largest holders

| Manager | Value | Shares | Share of their book | Quarters held |
|---|---|---|---|---|
| [T. Rowe Price Investment Management, Inc.](https://holderbook.com/funds/1897612-t-rowe-price-investment-management-inc/) | $3.0M | 30,092,327 | 0.0% | 6 |
| [VANGUARD GROUP INC](https://holderbook.com/funds/102909-vanguard-group-inc/) | $635.3K | 6,353,018 | 0.0% | 26 |
| [Knoll Capital Management, LLC](https://holderbook.com/funds/1325083-knoll-capital-management-llc/) | $605.0K | 6,050,000 | 0.3% | 27 |
| [DELTEC ASSET MANAGEMENT LLC](https://holderbook.com/funds/1269950-deltec-asset-management-llc/) | $384.7K | 3,847,449 | 0.1% | 1 |
| [BlackRock, Inc.](https://holderbook.com/funds/2012383-blackrock-inc/) | $325.1K | 3,251,462 | 0.0% | 6 |
| [Pathstone Holdings, LLC](https://holderbook.com/funds/2011612-pathstone-holdings-llc/) | $305.1K | 2,643,540 | 0.0% | 3 |
| [RENAISSANCE TECHNOLOGIES LLC](https://holderbook.com/funds/1037389-renaissance-technologies-llc/) | $270.6K | 2,706,156 | 0.0% | 1 |
| [JANE STREET GROUP, LLC](https://holderbook.com/funds/1595888-jane-street-group-llc/) | $208.7K | 2,087,404 | 0.0% | 3 |
| [GEODE CAPITAL MANAGEMENT, LLC](https://holderbook.com/funds/1214717-geode-capital-management-llc/) | $149.3K | 1,492,903 | 0.0% | 26 |
| [ADAGE CAPITAL PARTNERS GP, L.L.C.](https://holderbook.com/funds/1165408-adage-capital-partners-gp-l-l-c/) | $121.2K | 1,211,629 | 0.0% | 8 |
| [MILLENNIUM MANAGEMENT LLC](https://holderbook.com/funds/1273087-millennium-management-llc/) | $105.2K | 1,051,846 | 0.0% | 9 |
| [UBS Group AG](https://holderbook.com/funds/1610520-ubs-group-ag/) | $71.9K | 718,924 | 0.0% | 27 |
| [DEUTSCHE BANK AG\](https://holderbook.com/funds/948046-deutsche-bank-ag/) | $62.2K | 622,226 | 0.0% | 8 |
| [Graham Capital Management, L.P.](https://holderbook.com/funds/1315421-graham-capital-management-l-p/) | $57.3K | 572,759 | 0.0% | 1 |
| [STATE STREET CORP](https://holderbook.com/funds/93751-state-street-corp/) | $55.8K | 558,178 | 0.0% | 26 |
| [EQUITEC PROPRIETARY MARKETS, LLC](https://holderbook.com/funds/1143261-equitec-proprietary-markets-llc/) | $55.3K | 300,600 | 0.0% | 1 |
| [Virtu Financial LLC](https://holderbook.com/funds/1533964-virtu-financial-llc/) | $50.0K | 496,288 | 0.0% | 2 |
| [Lynx1 Capital Management LP](https://holderbook.com/funds/1910456-lynx1-capital-management-lp/) | $41.0K | 410,500 | 0.0% | 1 |
| [MARSHALL WACE, LLP](https://holderbook.com/funds/1318757-marshall-wace-llp/) | $33.7K | 337,389 | 0.0% | 6 |
| [Hennion & Walsh Asset Management, Inc.](https://holderbook.com/funds/1861642-hennion-walsh-asset-management-inc/) | $32.7K | 327,137 | 0.0% | 7 |
| [Bank of New York Mellon Corp](https://holderbook.com/funds/1390777-bank-of-new-york-mellon-corp/) | $25.4K | 253,573 | 0.0% | 7 |
| [NORTHERN TRUST CORP](https://holderbook.com/funds/73124-northern-trust-corp/) | $24.5K | 245,144 | 0.0% | 27 |
| [Rockefeller Capital Management L.P.](https://holderbook.com/funds/1739439-rockefeller-capital-management-l-p/) | $24.2K | 241,897 | 0.0% | 2 |
| [GTS SECURITIES LLC](https://holderbook.com/funds/1452765-gts-securities-llc/) | $20.0K | 200,009 | 0.0% | 1 |
| [CITADEL ADVISORS LLC](https://holderbook.com/funds/1423053-citadel-advisors-llc/) | $19.3K | 0 | 0.0% | 11 |

## Quarter by quarter

| Quarter | Holders | Reported value |
|---|---|---|
| Q4 2025 | 54 | $6.8M |
| Q3 2025 | 74 | $58.1M |
| Q2 2025 | 76 | $27.6M |
| Q1 2025 | 93 | $52.2M |
| Q4 2024 | 121 | $100.9M |
| Q3 2024 | 134 | $996.0M |
| Q2 2024 | 99 | $490.1M |
| Q1 2024 | 92 | $730.8M |
| Q4 2023 | 84 | $233.1M |
| Q3 2023 | 56 | $126.9M |
| Q2 2023 | 40 | $49.9M |
| Q1 2023 | 36 | $21.5M |