# PERCEPTIVE ADVISORS LLC

> Institutional holdings reported to the SEC as of Q2 2026 on Form 13F. CIK 1224962. Source: https://holderbook.com/funds/1224962-perceptive-advisors-llc/

- Reported value: $6.7B
- Positions: 108
- Weight of the ten largest: 47.3%
- Filed: 2026-08-14

A 13F reports long US equity positions only. Short positions, bonds, foreign listings, private holdings and cash are not visible, so this is not the manager's whole book.

## Holdings

| Security | Ticker | Value | Shares | Weight | Quarters held |
|---|---|---|---|---|---|
| PRAXIS PRECISION MEDICINES I | [PRAX](https://holderbook.com/stocks/PRAX/) | $681.6M | 2,035,986 | 10.2% | 10 |
| SPYRE THERAPEUTICS INC | [SYRE](https://holderbook.com/stocks/SYRE/) | $383.5M | 4,319,496 | 5.8% | 12 |
| CELCUITY INC | [CELC](https://holderbook.com/stocks/CELC/) | $334.5M | 3,197,200 | 5.0% | 11 |
| ASCENDIS PHARMA A/S | [ASND](https://holderbook.com/stocks/ASND/) | $310.4M | 1,163,721 | 4.7% | 1 |
| RHYTHM PHARMACEUTICALS INC | [RYTM](https://holderbook.com/stocks/RYTM/) | $287.2M | 2,586,295 | 4.3% | 12 |
| ROIVANT SCIENCES LTD | [ROIV](https://holderbook.com/stocks/ROIV/) | $286.1M | 8,085,461 | 4.3% | 5 |
| RELAY THERAPEUTICS INC | [RLAY](https://holderbook.com/stocks/RLAY/) | $263.9M | 14,106,187 | 4.0% | 3 |
| TRAVERE THERAPEUTICS INC | [TVTX](https://holderbook.com/stocks/TVTX/) | $213.2M | 3,752,574 | 3.2% | 5 |
| KARDIGAN INC | [KARD](https://holderbook.com/stocks/KARD/) | $195.6M | 8,200,662 | 2.9% | 1 |
| NUVALENT INC | [NUVL](https://holderbook.com/stocks/NUVL/) | $195.2M | 1,580,505 | 2.9% | 20 |
| EDGEWISE THERAPEUTICS INC | [EWTX](https://holderbook.com/stocks/EWTX/) | $177.7M | 4,373,974 | 2.7% | 11 |
| APOGEE THERAPEUTICS INC | [APGE](https://holderbook.com/stocks/APGE/) | $173.6M | 1,308,113 | 2.6% | 12 |
| AMYLYX PHARMACEUTICALS INC | [AMLX](https://holderbook.com/stocks/AMLX/) | $149.7M | 8,334,882 | 2.2% | 8 |
| MEIRAGTX HLDGS PLC | [MGTX](https://holderbook.com/stocks/MGTX/) | $145.7M | 10,786,658 | 2.2% | 31 |
| ORUKA THERAPEUTICS INC | [ORKA](https://holderbook.com/stocks/ORKA/) | $128.0M | 1,345,063 | 1.9% | 4 |
| INHIBRX BIOSCIENCES INC | [INBX](https://holderbook.com/stocks/INBX/) | $123.0M | 1,297,763 | 1.8% | 9 |
| PROTAGONIST THERAPEUTICS INC | [PTGX](https://holderbook.com/stocks/PTGX/) | $120.4M | 981,879 | 1.8% | 14 |
| SOLID BIOSCIENCES INC | [SLDB](https://holderbook.com/stocks/SLDB/) | $118.9M | 11,906,646 | 1.8% | 15 |
| ZYMEWORKS INC | [ZYME](https://holderbook.com/stocks/ZYME/) | $109.3M | 4,182,953 | 1.6% | 15 |
| TANGO THERAPEUTICS INC | [TNGX](https://holderbook.com/stocks/TNGX/) | $105.6M | 3,377,000 | 1.6% | 3 |
| IMMATICS N.V | [IMTX](https://holderbook.com/stocks/IMTX/) | $105.2M | 10,383,456 | 1.6% | 24 |
| NURIX THERAPEUTICS INC | [NRIX](https://holderbook.com/stocks/NRIX/) | $104.8M | 4,320,422 | 1.6% | 7 |
| BIOCRYST PHARMACEUTICALS INC | [BCRX](https://holderbook.com/stocks/BCRX/) | $103.1M | 10,308,888 | 1.5% | 3 |
| REVOLUTION MEDICINES INC | [RVMD](https://holderbook.com/stocks/RVMD/) | $98.8M | 527,600 | 1.5% | 2 |
| AVALYN PHARMACEUTICALS INC | [AVLN](https://holderbook.com/stocks/AVLN/) | $88.1M | 2,675,296 | 1.3% | 1 |
| MODERNA INC | [MRNA](https://holderbook.com/stocks/MRNA/) | $70.0M | 0 | 1.1% | 2 |
| DYNE THERAPEUTICS INC | [DYN](https://holderbook.com/stocks/DYN/) | $59.7M | 2,689,235 | 0.9% | 8 |
| BIOGEN INC | [BIIB](https://holderbook.com/stocks/BIIB/) | $59.7M | 276,173 | 0.9% | 1 |
| IMMUNOVANT INC | [IMVT](https://holderbook.com/stocks/IMVT/) | $52.3M | 1,357,383 | 0.8% | 15 |
| UNITEDHEALTH GROUP INC | [UNH](https://holderbook.com/stocks/UNH/) | $48.5M | 116,806 | 0.7% | 1 |
| SPDR SERIES TRUST | [XBI](https://holderbook.com/stocks/XBI/) | $47.5M | 0 | 0.7% | 1 |
| IONIS PHARMACEUTICALS INC | [IONS](https://holderbook.com/stocks/IONS/) | $44.9M | 566,000 | 0.7% | 2 |
| SUTRO BIOPHARMA INC | [STRO](https://holderbook.com/stocks/STRO/) | $43.3M | 1,304,846 | 0.7% | 2 |
| ALTO NEUROSCIENCE INC | [ANRO](https://holderbook.com/stocks/ANRO/) | $42.5M | 1,609,893 | 0.6% | 4 |
| JAZZ PHARMACEUTICALS PLC | [JAZZ](https://holderbook.com/stocks/JAZZ/) | $41.0M | 170,000 | 0.6% | 3 |
| CORVUS PHARMACEUTICALS INC | [CRVS](https://holderbook.com/stocks/CRVS/) | $39.9M | 2,667,441 | 0.6% | 5 |
| SIONNA THERAPEUTICS INC | [SION](https://holderbook.com/stocks/SION/) | $39.8M | 905,000 | 0.6% | 6 |
| CYTOMX THERAPEUTICS INC | [CTMX](https://holderbook.com/stocks/CTMX/) | $39.1M | 10,439,185 | 0.6% | 5 |
| ARTIVION INC | [AORT](https://holderbook.com/stocks/AORT/) | $39.0M | 1,737,290 | 0.6% | 19 |
| X4 PHARMACEUTICALS INC | [XFOR](https://holderbook.com/stocks/XFOR/) | $37.0M | 7,933,491 | 0.6% | 3 |
| CAPRICOR THERAPEUTICS INC | [CAPR](https://holderbook.com/stocks/CAPR/) | $36.1M | 0 | 0.5% | 1 |
| CORCEPT THERAPEUTICS INC | [CORT](https://holderbook.com/stocks/CORT/) | $34.6M | 398,385 | 0.5% | 2 |
| REPLIGEN CORP | [RGEN](https://holderbook.com/stocks/RGEN/) | $33.9M | 248,212 | 0.5% | 6 |
| ANTERIS TECHNOLOGIES GLOBAL | [AVR](https://holderbook.com/stocks/AVR/) | $33.7M | 3,425,476 | 0.5% | 7 |
| RAPPORT THERAPEUTICS INC | [RAPP](https://holderbook.com/stocks/RAPP/) | $32.2M | 773,342 | 0.5% | 4 |
| DAMORA THERAPEUTICS INC | [DMRA](https://holderbook.com/stocks/DMRA/) | $31.8M | 1,223,000 | 0.5% | 2 |
| CHARLES RIV LABS INTL INC | [CRL](https://holderbook.com/stocks/CRL/) | $31.8M | 140,000 | 0.5% | 1 |
| AXSOME THERAPEUTICS INC | [AXSM](https://holderbook.com/stocks/AXSM/) | $29.0M | 118,450 | 0.4% | 13 |
| EYEPOINT INC | [EYPT](https://holderbook.com/stocks/EYPT/) | $28.6M | 0 | 0.4% | 1 |
| DBV TECHNOLOGIES S A | [DBVT](https://holderbook.com/stocks/DBVT/) | $27.1M | 1,653,350 | 0.4% | 2 |
| IRHYTHM HOLDINGS INC | [IRTC](https://holderbook.com/stocks/IRTC/) | $26.6M | 223,766 | 0.4% | 4 |
| ADAPTIVE BIOTECHNOLOGIES COR | [ADPT](https://holderbook.com/stocks/ADPT/) | $26.1M | 1,217,325 | 0.4% | 2 |
| SAB BIOTHERAPEUTICS INC | [SABS](https://holderbook.com/stocks/SABS/) | $25.8M | 6,627,501 | 0.4% | 3 |
| DANAHER CORP DEL | [DHR](https://holderbook.com/stocks/DHR/) | $24.8M | 130,000 | 0.4% | 1 |
| TENAX THERAPEUTICS INC | [TENX](https://holderbook.com/stocks/TENX/) | $24.7M | 1,700,000 | 0.4% | 3 |
| SELLAS LIFE SCIENCES GROUP I | [SLS](https://holderbook.com/stocks/SLS/) | $22.1M | 0 | 0.3% | 1 |
| NAUTILUS BIOTECHNOLOGY INC | [NAUT](https://holderbook.com/stocks/NAUT/) | $21.8M | 11,634,211 | 0.3% | 21 |
| ORCHESTRA BIOMED HLDGS INC | [OBIO](https://holderbook.com/stocks/OBIO/) | $21.7M | 5,037,906 | 0.3% | 14 |
| INTUITIVE SURGICAL INC | [ISRG](https://holderbook.com/stocks/ISRG/) | $20.6M | 51,884 | 0.3% | 11 |
| ADLAI NORTYE LTD | [ANL](https://holderbook.com/stocks/ANL/) | $20.6M | 1,793,190 | 0.3% | 1 |
| CONTINEUM THERAPEUTICS INC | [CTNM](https://holderbook.com/stocks/CTNM/) | $20.6M | 1,255,592 | 0.3% | 9 |
| NUVECTIS PHARMA INC | [NVCT](https://holderbook.com/stocks/NVCT/) | $18.4M | 1,000,000 | 0.3% | 1 |
| PALISADE BIO INC | [PALI](https://holderbook.com/stocks/PALI/) | $17.6M | 8,425,065 | 0.3% | 3 |
| OMADA HEALTH INC | [OMDA](https://holderbook.com/stocks/OMDA/) | $17.3M | 786,330 | 0.3% | 5 |
| LEONABIO INC | [LONA](https://holderbook.com/stocks/LONA/) | $17.1M | 1,859,322 | 0.3% | 4 |
| EVOLUS INC | [EOLS](https://holderbook.com/stocks/EOLS/) | $17.1M | 2,459,285 | 0.3% | 2 |
| NEWAMSTERDAM PHARMA COMPANY | [NAMS](https://holderbook.com/stocks/NAMS/) | $16.9M | 0 | 0.3% | 1 |
| INVIVYD INC | [IVVD](https://holderbook.com/stocks/IVVD/) | $16.1M | 18,490,636 | 0.2% | 3 |
| CELCUITY INC | - | $14.6M | 6,500,000 | 0.2% | 4 |
| MIRUM PHARMACEUTICALS INC | [MIRM](https://holderbook.com/stocks/MIRM/) | $13.5M | 115,391 | 0.2% | 1 |
| SURROZEN INC | [SRZN](https://holderbook.com/stocks/SRZN/) | $13.1M | 503,985 | 0.2% | 2 |
| BETA BIONICS INC | [BBNX](https://holderbook.com/stocks/BBNX/) | $13.1M | 832,944 | 0.2% | 6 |
| AXOGEN INC | [AXGN](https://holderbook.com/stocks/AXGN/) | $11.4M | 247,312 | 0.2% | 3 |
| OSCAR HEALTH INC | [OSCR](https://holderbook.com/stocks/OSCR/) | $11.4M | 400,000 | 0.2% | 1 |
| OCULIS HOLDING AG | [OCS](https://holderbook.com/stocks/OCS/) | $11.2M | 808,827 | 0.2% | 3 |
| SEAPORT THERAPEUTICS INC | [SPTX](https://holderbook.com/stocks/SPTX/) | $10.9M | 500,000 | 0.2% | 1 |
| VIRIDIAN THERAPEUTICS INC | [VRDN](https://holderbook.com/stocks/VRDN/) | $10.7M | 581,980 | 0.2% | 21 |
| BOSTON SCIENTIFIC CORP | [BSX](https://holderbook.com/stocks/BSX/) | $10.7M | 250,000 | 0.2% | 1 |
| BILLIONTOONE INC | [BLLN](https://holderbook.com/stocks/BLLN/) | $10.4M | 86,812 | 0.2% | 3 |
| ABIVAX SA | [ABVX](https://holderbook.com/stocks/ABVX/) | $9.9M | 74,000 | 0.1% | 4 |
| NATERA INC | [NTRA](https://holderbook.com/stocks/NTRA/) | $9.4M | 34,689 | 0.1% | 1 |
| Engene Therapeutics Inc | [ENGN](https://holderbook.com/stocks/ENGN/) | $8.3M | 4,822,169 | 0.1% | 1 |
| RESEARCH ALLIANCE CORP III | [RACC](https://holderbook.com/stocks/RACC/) | $8.0M | 750,000 | 0.1% | 1 |
| AGOMAB THERAPEUTICS NV | [AGMB](https://holderbook.com/stocks/AGMB/) | $7.8M | 600,000 | 0.1% | 2 |
| CULLINAN THERAPEUTICS INC | [CGEM](https://holderbook.com/stocks/CGEM/) | $7.8M | 426,478 | 0.1% | 1 |
| UNIQURE NV | [QURE](https://holderbook.com/stocks/QURE/) | $7.7M | 168,000 | 0.1% | 1 |
| MOBIA MED INC | - | $7.0M | 523,654 | 0.1% | 1 |
| ADAGIO MED HLDGS INC | [ADGM](https://holderbook.com/stocks/ADGM/) | $6.4M | 9,876,586 | 0.1% | 8 |
| GUARDANT HEALTH INC | [GH](https://holderbook.com/stocks/GH/) | $6.2M | 41,327 | 0.1% | 3 |
| PHATHOM PHARMACEUTICALS INC | [PHAT](https://holderbook.com/stocks/PHAT/) | $5.8M | 532,000 | 0.1% | 2 |
| OUTLOOK THERAPEUTICS INC | [OTLK](https://holderbook.com/stocks/OTLK/) | $5.0M | 3,139,216 | 0.1% | 1 |
| COGENT BIOSCIENCES INC | [COGT](https://holderbook.com/stocks/COGT/) | $4.7M | 121,082 | 0.1% | 3 |
| EDESA BIOTECH INC | [EDSA](https://holderbook.com/stocks/EDSA/) | $4.6M | 563,239 | 0.1% | 2 |
| AVALO THERAPEUTICS INC | [AVTX](https://holderbook.com/stocks/AVTX/) | $4.1M | 219,813 | 0.1% | 6 |
| TWIST BIOSCIENCE CORP | [TWST](https://holderbook.com/stocks/TWST/) | $3.8M | 36,812 | 0.1% | 2 |
| CRESCENT BIOPHARMA INC. | [CBIO](https://holderbook.com/stocks/CBIO/) | $3.7M | 206,942 | 0.1% | 5 |
| XERIS BIOPHARMA HOLDINGS INC | [XERS](https://holderbook.com/stocks/XERS/) | $3.7M | 467,013 | 0.1% | 1 |
| OUTSET MED INC | [OM](https://holderbook.com/stocks/OM/) | $3.6M | 833,333 | 0.1% | 6 |
| BIODESIX INC | [BDSX](https://holderbook.com/stocks/BDSX/) | $2.5M | 108,694 | 0.0% | 1 |
| REVOLUTION MEDICINES INC | [RVMDW](https://holderbook.com/stocks/RVMDW/) | $2.3M | 250,000 | 0.0% | 11 |

## What the disclosed book did

Not the fund's return. This is the change in value of the positions disclosed on Form 13F, had they been left untouched, against SPY over the same quarter ends.

| Quarter | Book | Market | Difference | Priced |
|---|---|---|---|---|
| Q2 2026 | +21.7% | +14.8% | +6.9% | 95% |
| Q1 2026 | +3.5% | -4.6% | +8.1% | 97% |
| Q4 2025 | +37.5% | +2.4% | +35.1% | 96% |
| Q3 2025 | +26.5% | +7.8% | +18.7% | 100% |
| Q2 2025 | +5.8% | +10.5% | -4.6% | 99% |
| Q1 2025 | -11.4% | -4.6% | -6.9% | 99% |
| Q4 2024 | -10.0% | +2.1% | -12.1% | 100% |
| Q3 2024 | +19.2% | +5.4% | +13.8% | 89% |

## Quarter by quarter

| Quarter | Value | Positions |
|---|---|---|
| Q2 2026 | $6.7B | 108 |
| Q1 2026 | $5.1B | 94 |
| Q4 2025 | $5.6B | 116 |
| Q3 2025 | $3.5B | 92 |
| Q2 2025 | $2.7B | 84 |
| Q1 2025 | $2.8B | 86 |
| Q4 2024 | $3.6B | 98 |
| Q3 2024 | $4.7B | 106 |
| Q2 2024 | $4.2B | 109 |
| Q1 2024 | $5.7B | 108 |
| Q4 2023 | $4.5B | 99 |
| Q3 2023 | $3.0B | 95 |